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In prostate adenocarcinoma, ORC6 showed positive links with T regulatory cell infiltration and with immunosuppression markers including TGFBR1 and PD-L1.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/orc6-a-novel-prognostic-biomarker-correlates-with-t-regulatory-cell-infiltration-in-prostate-adenocarcinoma-a-pan-cancer-analysis/377707/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/orc6-a-novel-prognostic-biomarker-correlates-with-t-regulatory-cell-infiltration-in-prostate-adenocarcinoma-a-pan-cancer-analysis/377707.png","ImageObject",300,407,{"name":42,"@type":43},"Lucas Martin","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-26","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":22},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What is ORC6 and why is it studied in cancer?","Question",{"text":62,"@type":63},"ORC6 is the smallest subunit of the origin recognition complex, a DNA-binding factor required for replication initiation. 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BMC Cancer (2023) 23:285  \n[https://doi.org/10.1186/s12885-023-10763-z](https://doi.org/10.1186/s12885-023-10763-z)  \nBMC Cancer  \n RESEARCH Open Access  \nORC6, a novel prognostic biomarker,   correlates with T regulatory cell infiltration in prostate adenocarcinoma: a pan-cancer analysis  \nYuan Lin1†, Ying Zhang1†, Zhouting Tuo1, Liang Gao2, Demao Ding1, Liangkuan Bi 1, Dexin Yu1, Zhengmei Lv3, Jiani Wang4,5,6 and Xin Chen1*  \nAbstract  \nBackground The origin recognition complex (ORC), a six-subunit DNA-binding complex, participates in DNA replication in cancer cells. Specifically in prostate cancers, ORC participates the androgen receptor (AR) regulated genomic amplification and tumor proliferation throughout the entire cell cycle. Of note, ORC6, the smallest subunit of ORC, has been reported to be dysregulated in some types of cancers (including prostate cancer), however, its prognostic and immunological significances remain yet to be elucidated.  \nMethods In the current study, we comprehensively investigated the potential prognostic and immunological role of ORC6 in 33 human tumors using multiple databases, such as TCGA, Genotype-Tissue Expression, CCLE, UCSC Xena, cBioPortal, Human Protein Atlas, GeneCards, STRING, MSigDB, TISIDB, and TIMER2 databases.  \nResults ORC6 expression was significantly upregulated in 29 types of cancers compared to the corresponding normal adjacent tissues. ORC6 overexpression correlated with higher stage and worse prognostic outcomes in most cancer types analyzed. Additionally, ORC6 was involved in the cell cycle pathway, DNA replication, and mismatch repair pathways in most tumor types. A negative correlation was observed between the tumor endothelial cell infiltration and ORC6 expression in almost all tumors, whereas the immune infiltration ofT regulatory cell was noted to be statistically positively correlated with the expression of ORC6 in prostate cancer tissues. Furthermore, in most tumor types, immunosuppression-related genes, especially TGFBR1 and PD-L1 (CD274), exhibited a specific correlation with the expression of ORC6 .  \nConclusions This comprehensive pan-cancer analysis revealed that ORC6 expression serves as a prognostic biomarker and that ORC6 is involved in the regulation of various biological pathways, the tumor microenvironment, and the immunosuppression status in several human cancers, suggesting its potential diagnostic, prognostic, and therapeutic value in pan-cancer, especially in prostate adenocarcinoma.  \nKeywords ORC6, Pan-cancer, Prognosis, Prostate adenocarcinoma, Immunotherapy  \n†Yuan Lin andYing Zhang contributed equally to this work.  \n*Correspondence:  \nXin Chen  \n[chenxin704679314@163.com](chenxin704679314@163.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[. The Creative Commons Public Domain Dedication waiver (](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[http://creativeco](http://creativeco)[mmons.org/publ","cbCaira29xDthxb4","https://ap.wps.com/l/cbCaira29xDthxb4","pdf",15136536,16,"English","# Abstract\n# Introduction\n## ORC and ORC6 background","[{\"question\":\"What is ORC6 and why is it studied in cancer?\",\"answer\":\"ORC6 is the smallest subunit of the origin recognition complex, a DNA-binding factor required for replication initiation. Prior reports show ORC6 can be dysregulated in cancers, but its prognostic and immunological significance needed clarification.\"},{\"question\":\"How was ORC6 evaluated across tumors in this study?\",\"answer\":\"The study analyzed ORC6 expression and associations using multiple public databases covering 33 tumor types, including TCGA and related analytical resources, to assess prognostic and immune-related patterns.\"},{\"question\":\"What immune relationship is reported for prostate adenocarcinoma?\",\"answer\":\"In prostate cancer tissues, ORC6 expression correlated statistically positively with immune infiltration of T regulatory cells, alongside correlations with immunosuppression-related genes such as TGFBR1 and PD-L1 (CD274).\"}]","ORC6, a Novel Prognostic Biomarker - Correlates with T Regulatory Cell Infiltration in Prostate Adenocarcinoma - A Pan-cancer Analysis | PDF",1790226774]