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Methods use a single-center prospective cross-sectional design of 300 surgical oncology patients who underwent standardized oral exams before planned oncologic surgery. Results find classical paraneoplastic oral syndromes absent; oral candidiasis is mainly in advanced disease, while labial and lingual hypoperfusion and tongue morphology show tumor-specific associations. Conclusion Traditional manifestations were virtually absent, but perfusion changes and tongue morphology may support early indicator research.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/oral-paraneoplastic-manifestations-and-findings-associated-with-extra-oral-surgically-treated-malignancies-a-prospective-cross-sectional-study-of-300-cases/351683/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/oral-paraneoplastic-manifestations-and-findings-associated-with-extra-oral-surgically-treated-malignancies-a-prospective-cross-sectional-study-of-300-cases/351683.png","ImageObject",300,407,{"name":92,"@type":93},"Adam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main aim of the study?","Question",{"text":112,"@type":113},"To determine the prevalence of oral paraneoplastic manifestations in patients with biopsy-confirmed extraoral malignancies and to identify oral findings with potential paraneoplastic significance for dental screening targets.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the study conducted?",{"text":117,"@type":113},"A single-center prospective cross-sectional study enrolled 300 consecutive surgical oncology patients who received standardized oral examinations one day before planned oncologic surgery.",{"name":119,"@type":110,"acceptedAnswer":120},"What key findings were reported regarding classic oral paraneoplastic syndromes?",{"text":121,"@type":113},"Classical paraneoplastic oral syndromes were not detected in this cohort, while specific simple clinical findings such as perfusion changes and tongue morphology showed frequent tumor-specific associations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},351683,1790156663,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},1374404737137,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Liskova et al. World Journal of Surgical Oncology (2026) 24:210  \n[https://doi.org/10.1186/s12957-026-04317-3](https://doi.org/10.1186/s12957-026-04317-3)  \nWorld Journal of Surgical Oncology  \nRESEARCH Open Access  \nOral paraneoplastic manifestations   \nand findings associated with extra-oral surgically treated malignancies: a prospective cross-sectional study of 300 cases  \nVeronika Liskova1,2, Jan Liska1,2*, Nikoleta Molnarova1,2, Lucie Nechutna1,2, Ondrej Topolcan2,3, Ladislav Pecen2,3, Ilona Zednikova2,4, Tomas Skalicky2,4 and Jiri Molacek2,4  \nAbstract  \nBackground To assess the prevalence of oral paraneoplastic manifestations in patients with biopsy-confirmed extraoral malignancies and to identify oral findings with potential paraneoplastic significance that could serve as new targets for dental screening.  \nMethods A single-center prospective cross-sectional study was performed. A total of 300 consecutive surgical oncology patients (April 2024–September 2025) underwent standardized oral examinations one day prior to planned oncologic surgery. Extraoral and intraoral findings—including mucosal changes, perfusion abnormalities, tongue morphology, and candidal colonization—were evaluated by oral medicine specialists. Only primary extraoral malignancies were included and categorized into upper gastrointestinal, colorectal, hepatopancreatic, lung, and breast cancer. Mycological cultures were obtained in all patients. Statistical assessment used Chi-square test, multivariate stepwise selection logistic regression models and univariate models of selected confounders (SAS software) .  \nResults Classical paraneoplastic oral syndromes (e. g., paraneoplastic pemphigus, acanthosis nigricans) were not detected. Oral candidiasis was uncommon and appeared mainly in patients with advanced disease, suggesting limited usefulness as an early indicator. In contrast, labial and lingual hypoperfusion occurred significantly more often in gastrointestinal cancers (p ≤ 0. 0001, labial hypoperfusion was differentiated in 25 . 5%(24/94) of gastrointestinal malignancies) . Patients with breast cancer showed a markedly higher prevalence of tongue enlargement and dental impressions (both p \u003C 0. 0001, with tongue enlargement detected in 51,3%(80/159) of cases), as well as lateral deviation during protrusion (p = 0 . 0152) .  \nConclusion Traditional oral paraneoplastic manifestations were virtually absent in this cohort. However, simple clinical findings—particularly perfusion changes and tongue morphology—showed frequent tumor-specific associations and may merit further investigation for the verification as potential early paraneoplastic indicators. As  \n*Correspondence: Jan Liska[liskaj@fnplzen.cz](liskaj@fnplzen.cz)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/licenses/by-nc-nd/4.0/](vecommons.org/licenses/by-nc-nd/4.0/.)[.](vecommons.org/licenses/by-nc-nd/4.0/.)  \nLiskova et al. World Journal of Su","cbCaibJUyWnbnvpV","https://ap.wps.com/l/cbCaibJUyWnbnvpV","pdf",1811032,12,"English","# Background\n# Methods\n# Results\n# Conclusion\n# Keywords","[{\"question\":\"What was the main aim of the study?\",\"answer\":\"To determine the prevalence of oral paraneoplastic manifestations in patients with biopsy-confirmed extraoral malignancies and to identify oral findings with potential paraneoplastic significance for dental screening targets.\"},{\"question\":\"How was the study conducted?\",\"answer\":\"A single-center prospective cross-sectional study enrolled 300 consecutive surgical oncology patients who received standardized oral examinations one day before planned oncologic surgery.\"},{\"question\":\"What key findings were reported regarding classic oral paraneoplastic syndromes?\",\"answer\":\"Classical paraneoplastic oral syndromes were not detected in this cohort, while specific simple clinical findings such as perfusion changes and tongue morphology showed frequent tumor-specific associations.\"}]","Oral paraneoplastic manifestations and findings associated with extra-oral surgically treated malignancies: a prospective cross-sectional study of 300 cases | PDF",1790095302]