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Sequencing advances clarify the oral microbiota and how dysbiosis—imbalanced bacterial communities—can influence oral disorders such as caries and inflammation as well as systemic diseases and distant cancers. This narrative review assesses links between oral microbiota and gastrointestinal cancers by searching major databases from 2014–2024.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/oral-microbiota-and-the-risk-of-gastrointestinal-cancers-a-narrative-literature-review/332514/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/oral-microbiota-and-the-risk-of-gastrointestinal-cancers-a-narrative-literature-review/332514.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the focus of this narrative literature review?","Question",{"text":113,"@type":114},"The review evaluates the relationship between oral microbiota and the risk of gastrointestinal cancers.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the literature searched for relevant studies?",{"text":118,"@type":114},"The authors used database searches with the keywords “oral microbiota” AND “gastrointestinal cancers” across PubMed, Web of Science, and Scopus for articles published between 2014 and 2024.",{"name":120,"@type":111,"acceptedAnswer":121},"Which gastrointestinal cancer types are discussed in relation to oral microbiota?",{"text":122,"@type":114},"The review describes associations with oral, esophageal, gastric, colorectal, hepatocellular, and pancreatic cancers.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332514,1790015720,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","pathogens   \nReview  \nOral Microbiota and the Risk of Gastrointestinal Cancers—A Narrative Literature Review  \nKinga Knop-Chodyła 1, Anna Kochanowska-Mazurek 2, Zuzanna Piasecka 3, Aneta Głaz 4, Ewelina Weronika Wesołek-Bielaska 1, Kinga Syty 5, Alicja Forma 6, * and Jacek Baj 7  \nCitation: Knop-Chodyła, K.; Kochanowska-Mazurek, A.; Piasecka, Z.; Głaz, A.; Wesołek-Bielaska, E.W.; Syty, K.; Forma, A.; Baj, J. Oral Microbiota and the Risk of Gastrointestinal Cancers  \n—A Narrative Literature Review. Pathogens 2024, 13, 819 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)pathogens13090819  \nAcademic Editor: Jorge Luis Espinoza  \nReceived: 15 August 2024  \nRevised: 9 September 2024  \nAccepted: 17 September 2024  \nPublished: 23 September 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 University Clinical Hospital Number 4 in Lublin, Jaczewskiego 8, 20-954 Lublin, Poland; [kinga.knop03@gmail.com](kinga.knop03@gmail.com) (K.K.-C.); [ewelina_wesolek96@wp.pl](ewelina_wesolek96@wp.pl) (E.W.W.-B.)  \n2 Stefan Cardinal Wyszynski Province Specialist Hospital, al. Kra´snicka 100, 20-718 Lublin, Poland; [aniako19@gmail.com](aniako19@gmail.com)  \n3 Saint Queen Jadwiga’s Regional Clinical Hospital Number 2 in Rzeszow, Lwowska 60, 35-301 Rzeszów, Poland; [zuz.pia@wp.pl](zuz.pia@wp.pl)  \n4 Faculty of Medicine, Medical University of Lublin, al. Racławickie 1, 20-059 Lublin, Poland; [glaz.aneta11@gmail.com](glaz.aneta11@gmail.com)  \n5 Institute of Health Sciences, John Paul the II Catholic University of Lublin, Konstantynów 1G, 20-708 Lublin, Poland; [kinga.syty@kul.pl](kinga.syty@kul.pl)  \n6 Department of Forensic Medicine, Medical University of Lublin, Jaczewskiego 8b, 20-090 Lublin, Poland  \n7 Department of Correct, Clinical and Imaging Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland; [jacek.baj@umlub.pl](jacek.baj@umlub.pl)  \n* Correspondence: [formaalicja@gmail.com](formaalicja@gmail.com)  \nAbstract: The human body is colonized by trillions of microorganisms in a symbiotic relationship. The oral cavity represents one of the most abundant microbial habitats in our body. Advancesin sequencing techniques provide a more detailed understanding of the oral microbiota and how imbalances between bacteria, the phenomenon of dysbiosis, can affect not only the development of dental caries or inflammation within the oral cavity but also systemic diseases and cancers in distant locations. This narrative review evaluates the relationship between oral microbiota and its impact on gastrointestinal cancers. Using the keywords “oral microbiota ‘AND’ gastrointestinal cancers”, the PubMed Web of Science and Scopus databases were searched for articles published between 2014 and 2024 . Based on the review, the relationship between oral microbiota and oral, esophageal, gastric, colorectal, hepatocellular, and pancreatic cancers was described. Potential oncogenic mechanisms exploited by the microbiota such as the production of pro-inflammatory cytokines, induction of abnormal immune responses, and disruption of cell metabolic pathways were assessed. Further research and a thorough understanding of the impact of the oral microbiota on the development of cancers of the gastrointestinal tract may play a key role in their prevention, diagnosis, and treatment in the future.  \nKeywords: oral microbiota; gastrointestinal cancer; oral cancer; gastric cancer; esophageal cancer; colorectal cancer; pancreatic cancer; hepatocellular carcinoma  \n1. Introduction  \nBacteria inhabiting the oral cavity have come to be known as the “oral microbiota” [1]. According to the expanded Human Oral Microbiome Datab","cbCaivRSwYZ63iwJ","https://ap.wps.com/l/cbCaivRSwYZ63iwJ","pdf",437620,"English","# 1. Introduction\n# 2. Methods\n## Search strategy\n# 3. Findings and discussion\n## Oncogenic mechanisms","[{\"question\":\"What is the focus of this narrative literature review?\",\"answer\":\"The review evaluates the relationship between oral microbiota and the risk of gastrointestinal cancers.\"},{\"question\":\"How was the literature searched for relevant studies?\",\"answer\":\"The authors used database searches with the keywords “oral microbiota” AND “gastrointestinal cancers” across PubMed, Web of Science, and Scopus for articles published between 2014 and 2024.\"},{\"question\":\"Which gastrointestinal cancer types are discussed in relation to oral microbiota?\",\"answer\":\"The review describes associations with oral, esophageal, gastric, colorectal, hepatocellular, and pancreatic cancers.\"}]","Oral Microbiota and the Risk of Gastrointestinal Cancers - A Narrative Literature Review | PDF",1789998559,38]