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Some off-label uses are effective, while others fail, making evidence updates critical for clinicians selecting appropriate treatment.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/oral-isotretinoin-and-its-uses-in-dermatology-a-review/380343/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/oral-isotretinoin-and-its-uses-in-dermatology-a-review/380343.png","ImageObject",300,407,{"name":42,"@type":43},"นรินทร์","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was isotretinoin approved for in 1982 by the FDA?","Question",{"text":63,"@type":64},"Isotretinoin was approved to treat severe recalcitrant acne vulgaris.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Why is isotretinoin commonly used off-label in dermatology?",{"text":68,"@type":64},"Off-label use is supported by its anti-inflammatory, immunomodulatory, and antineoplastic properties, which may benefit multiple skin disorders.",{"name":70,"@type":61,"acceptedAnswer":71},"How can clinicians decide when isotretinoin is appropriate for acne patients?",{"text":72,"@type":64},"Clinicians consider disease severity, response to conventional therapy, presence of scarring with significant psychological distress, and prognostic factors such as family history and early onset.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},380343,1790665041,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":128,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},2336475104957,"https://ap-avatar.wpscdn.com/avatar/22000c4c6bd8a5076e1?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787554080175789136","Drug Design, Development and Therapy Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article REVIEW  \nOral Isotretinoin and Its Uses in Dermatology: A Review  \nAnon Paichitrojjana 1 , Anand Paichitrojjana 2  \n1School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University, Bangkok, Thailand; 2Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand  \nCorrespondence: Anon Paichitrojjana, School of Anti-Aging and Regenerative Medicine, Mae Fah Luang University, 36/87-88 PS Tower 25Fl, Asoke Road, Sukhumvit 21, Klong Toey Nua, Wattana, Bangkok, 10110, Thailand, Tel +66-81-9343050, Email [anonpaic@gmail.com](anonpaic@gmail.com)  \n\n| Abstract: In 1982, the Food and Drug Administration (FDA) of the United States of America approved isotretinoin (13-cis-retinoic acid), a retinoid derivative of vitamin A, to treat severe recalcitrant acne vulgaris. Apart from its prescribed use for severe acne, evidence suggests that isotretinoin is commonly used off-label to treat mild-to-moderate acne, inflammatory skin conditions, genodermatoses, skin cancer, and other skin disorders. This is due to its anti-inflammatory, immunomodulatory, and antineoplastic properties. Some “off-label” use is successful, while others are ineffective. Therefore, this information is essential to clinicians for deciding on the appropriate use of isotretinoin. In this article, we aim to review the most updated evidence-based data about the use of oral isotretinoin in dermatology.\u003Cbr>Keywords: isotretinoin, acne vulgaris, rosacea, skin cancer, dermatology |\n| --- |\n| Introduction\u003Cbr>Isotretinoin (13-cis-retinoic acid) is a retinoid derivative of vitamin A approved by the FDA of the United States and Europe (excluding Sweden) in 1982 and 1983, respectively. Its primary use is for treating severe recalcitrant cases of acne vulgaris.1,2\u003Cbr>Isotretinoin is a highly effective acne treatment. It works by reducing the size of sebaceous glands, lowering sebum excretion, regulating cell proliferation, and decreasing keratinization. Isotretinoin can alter the microenvironment of the follicles, resulting in a decrease in the number of Cutibacterium acnes.3,4 Additionally, it possesses anti-inflammatory and immunomodulatory properties by reducing monocyte TLR-2 expression, minimizing the inflammatory cytokine response, and antineoplastic properties, making it a valuable treatment option for various skin diseases.5,6\u003Cbr>According to data, a lot of isotretinoin is being utilized off-label to treat mild-to-moderate acne, inflammatory skin diseases, genodermatoses, skin cancer, and other skin disorders.7–9 Some “off-label” use is successful, while others are ineffective. Therefore, this information is essential to clinicians for deciding on the appropriate use of isotretinoin. This review aims to review the most updated evidence-based data about the use of oral isotretinoin in dermatology.\u003Cbr>Use of Oral Isotretinoin in Acne\u003Cbr>Although isotretinoin is labeled by FDA only for treating severe recalcitrant acne, there is a consensus among the expert’s opinion that patients with less severe acne who do not respond to conventional therapy and patients with scarring acne that causes severe psychologic distress may also be good candidates for this drug.10\u003Cbr>Prognostic factors which should be considered for the early use ofisotretinoin include a family history of severe acne, early onset of acne, hyper seborrhea, truncal acne, scarring acne, psychosocial problems, and persistent acne.11\u003Cbr>The conventional dosage ofisotretinoin is 0.5 to 1 mg/kg/day in two divided doses with a standard cumulative dosage of 120 to 150 mg/kg/course. Managing patients with acne can vary based on different guidelines and consensus. The |\n\nReceived: 25 June 2023  \nAccepted: 20 August 2023  \nPublished: 25 August 2023  \nDrug Design, Development and Therapy 2023:17 2573–2591 2573  \n© 2023 Paichitrojjana and Paichitrojjana. This work is published ","cbCainz0IVUU9dWx","https://ap.wps.com/l/cbCainz0IVUU9dWx","pdf",709869,"English","# Introduction\n# Use of Oral Isotretinoin in Acne","[{\"question\":\"What was isotretinoin approved for in 1982 by the FDA?\",\"answer\":\"Isotretinoin was approved to treat severe recalcitrant acne vulgaris.\"},{\"question\":\"Why is isotretinoin commonly used off-label in dermatology?\",\"answer\":\"Off-label use is supported by its anti-inflammatory, immunomodulatory, and antineoplastic properties, which may benefit multiple skin disorders.\"},{\"question\":\"How can clinicians decide when isotretinoin is appropriate for acne patients?\",\"answer\":\"Clinicians consider disease severity, response to conventional therapy, presence of scarring with significant psychological distress, and prognostic factors such as family history and early onset.\"}]","Oral Isotretinoin and Its Uses in Dermatology - A Review | PDF",1790239796,48]