[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-381756-105":59,"doc-detail-381756-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","opuntia-ficus-indica-l-mill-anticancer-properties-and-phytochemicals-current-trends-and-future-perspectives","Opuntia ficus-indica (L.) Mill. - Anticancer properties and phytochemicals - current trends and future perspectives","","Cancer remains a leading cause of mortality worldwide, while chemotherapy and radiotherapy often bring substantial adverse effects. This review highlights Opuntia ficus-indica (L.) Mill., whose phytochemical constituents—flavonoids, polyphenols, betalains, and tannins—are associated with potent anticancer activities. Evidence across plant parts and studies emphasizes mechanisms including apoptosis, cell-cycle arrest, Bcl-2 modulation, oxidative-stress–mediated pathways, and cytochrome c, with bibliometric analysis using PubMed/Scopus data to identify research gaps.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/opuntia-ficus-indica-l-mill-anticancer-properties-and-phytochemicals-current-trends-and-future-perspectives/381756/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/opuntia-ficus-indica-l-mill-anticancer-properties-and-phytochemicals-current-trends-and-future-perspectives/381756.png","ImageObject",300,407,{"name":92,"@type":93},"Dipper","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is Opuntia ficus-indica (L.) Mill. considered promising for cancer research?","Question",{"text":113,"@type":114},"The review describes its diverse phytochemicals—such as flavonoids, polyphenols, betalains, and tannins—that have been shown to exhibit anticancer activities with comparatively fewer side effects than conventional therapies.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which cancer types receive the most research attention, and which ones are less studied?",{"text":118,"@type":114},"Most studies focus on colorectal/colon cancer, followed by melanoma and breast cancer, while leukemia, thyroid, endometrial, liver, and prostate cancer receive comparatively little attention.",{"name":120,"@type":111,"acceptedAnswer":121},"What anticancer mechanisms are highlighted as most notable in existing studies?",{"text":122,"@type":114},"Validated mechanisms include apoptosis, cell-cycle arrest (G0/G1 and G2/M), Bcl-2 modulation, antiproliferative effects, oxidative-stress–mediated pathways, and cytochrome c.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},381756,1790293496,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","TYPE Review  \nPUBLISHED 04 October 2023 DOI 10.3389/fpls.2023.1236123  \nOPEN ACCESS  \nEDITED BY  \nChunpeng (Craig) Wan,  \nJiangxi Agricultural University, China  \nREVIEWED BY Enrico Doria,  \nUniversity of Pavia, Italy  \nDamilohun Samuel Metibemu, Jackson State University, United States Maryna De Wit,  \nUniversity of the Free State, South Africa  \n*CORRESPONDENCE Rajeev K. Singla  \n [rajeesingla26@gmail.com](rajeesingla26@gmail.com)[ ](rajeesingla26@gmail.com)Bhagwati Devi  \n [bhagwatidevi2013@gmail.com](bhagwatidevi2013@gmail.com)[ ](bhagwatidevi2013@gmail.com)Bairong Shen  \n [bairong.shen@scu.edu.cn](bairong.shen@scu.edu.cn)  \n†These authors have contributed equally to this work and share first authorship  \nRECEIVED 07 June 2023  \nACCEPTED 13 September 2023  \nPUBLISHED 04 October 2023  \nCITATION  \nWang J, Rani N, Jakhar S, Redhu R, Kumar S, Kumar S, Kumar S, Devi B, Simal-Gandara J, Shen B and Singla RK (2023) Opuntia ficus-indica (L.) Mill. -anticancer properties and phytochemicals:  \ncurrent trends and future perspectives. Front. Plant Sci. 14:1236123 .  \ndoi: 10.3389/fpls.2023.1236123  \nCOPYRIGHT  \n© 2023 Wang, Rani, Jakhar, Redhu, Kumar, Kumar, Kumar, Devi, Simal-Gandara, Shen and Singla. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nOpuntia ficus-indica (L.) Mill. -anticancer properties and phytochemicals: current trendsand future perspectives  \nJiao Wang1†, Neeraj Rani 2,3†, Seema Jakhar 4, Rakesh Redhu 4, Sanjiv Kumar 3, Sachin Kumar 3, Sanjeev Kumar 3,  \nBhagwati Devi 2*, Jesus Simal-Gandara 5, Bairong Shen 1* and Rajeev K. Singla 1,6*  \n1Joint Laboratory of Artificial Intelligence for Critical Care Medicine, Department of Critical Care Medicine and Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, China, 2Shri Baba Mastnath Institute of Pharmaceutical Science and Research, Baba Mastnath University, Asthal Bohar Rohtak, Haryana, India, 3 Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, India,  \n4Geeta Institute of Pharmacy, Geeta University, Panipat, Haryana, India, 5 Universidade de Vigo, Nutrition and Bromatology Group, Analytical Chemistry and Food Science Department, Faculty of Science, Ourense, Spain, 6School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India  \nCancer is a leading cause of mortality worldwide, and conventional cancer therapies such as chemotherapy and radiotherapy often result in undesirable and adverse effects. Natural products have emerged as a promising alternative for cancer treatment, with comparatively fewer side effects reported. Opuntia ficus-indica (L.) Mill., a member of the Cactaceae family, contains a diverse array of phytochemicals, including flavonoids, polyphenols, betalains, and tannins, which have been shown to exhibit potent anticancer properties. Various parts of the Opuntia plant, including the fruits, stems/cladodes, and roots, have demonstrated cytotoxic effects against malignant cell lines in numerous studies. This review comprehensively summarizes the anticancer attributes of the phytochemicals found in Opuntia ficus-indica (L.) Mill., highlighting their potential as natural cancer prevention and treatment agents. Bibliometric metric analysis of PubMed and Scopus-retrieved data using VOSviewer as well as QDA analysis provide further insights and niche to be explored. Most anticancer studies on Opuntia ficus-indica and its purified metabolites are related to colorectal/colon cancer, followed by melanoma and breast can","cbCaimxAkPvNo2lf","https://ap.wps.com/l/cbCaimxAkPvNo2lf","pdf",5139291,21,"English","# Introduction\n## Anticancer overview and rationale\n# Anticancer properties of phytochemicals\n## Phytochemical constituents and observed cytotoxic effects\n# Research trends and evidence distribution\n## Cancer types studied and underexplored areas\n# Mechanisms of action\n## Apoptosis, cell-cycle arrest, Bcl-2, oxidative stress, cytochrome c\n# Future perspectives\n## Model systems and need for clinical validation","[{\"question\":\"Why is Opuntia ficus-indica (L.) Mill. considered promising for cancer research?\",\"answer\":\"The review describes its diverse phytochemicals—such as flavonoids, polyphenols, betalains, and tannins—that have been shown to exhibit anticancer activities with comparatively fewer side effects than conventional therapies.\"},{\"question\":\"Which cancer types receive the most research attention, and which ones are less studied?\",\"answer\":\"Most studies focus on colorectal/colon cancer, followed by melanoma and breast cancer, while leukemia, thyroid, endometrial, liver, and prostate cancer receive comparatively little attention.\"},{\"question\":\"What anticancer mechanisms are highlighted as most notable in existing studies?\",\"answer\":\"Validated mechanisms include apoptosis, cell-cycle arrest (G0/G1 and G2/M), Bcl-2 modulation, antiproliferative effects, oxidative-stress–mediated pathways, and cytochrome c.\"}]","Opuntia ficus-indica (L.) Mill. - Anticancer properties and phytochemicals - current trends and future perspectives | PDF",1790246925,53]