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It targets cerebrospinal fluid partial volume effects by using a closed-form algorithm with water-volume separation. Simulations, phantom, and brain MRI data with noise assess relative error and coefficient of variation across TE and b-value patterns using closed-form and least-squares fitting. Best accuracy is achieved with ≥4 data points using the closed-form strategy, and with more points via optimized b-value/TE and 2-exponential LSQ fitting.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/optimization-of-the-data-pattern-and-analysis-algorithm-for-the-t2-based-water-suppression-diffusion-mrimaging-t2wsup-dmri-technique/444598/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/optimization-of-the-data-pattern-and-analysis-algorithm-for-the-t2-based-water-suppression-diffusion-mrimaging-t2wsup-dmri-technique/444598.png","ImageObject",300,407,{"name":92,"@type":93},"Elsa","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-05","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does the T2-based water suppression diffusion MRI (T2wsup-dMRI) technique address?","Question",{"text":112,"@type":113},"It addresses parameter quantification errors caused by cerebrospinal fluid partial volume effects when CSF mixes with gray or white matter within the same voxel.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which algorithm is used for water-volume separation in the proposed method?",{"text":117,"@type":113},"The study uses a closed-form (CF) algorithm that separates water volume and supports computation of tissue-specific Q-maps.",{"name":119,"@type":110,"acceptedAnswer":120},"How many data points are required for the closed-form approach to work optimally?",{"text":121,"@type":113},"The results indicate that using 4 minimum data points in healthy brain tissue (with T2 \u003C 100 ms) makes the CF algorithm with water volume separation optimal; for more than 4 points, a different optimized least-squares strategy performs best.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},444598,1790986697,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},137455077381,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Magn Reson Med Sci 2025 ; 24: 2024-0181  \n[doi:10.2463/mrms.tn.2024-0181 Published Online: May 24](doi:10.2463/mrms.tn.2024-0181 Published Online: May 24), 2025  \nTECHNICAL NOTE  \nOptimization of the Data Pattern and Analysis Algorithm for the T2-based Water Suppression Diffusion MRImaging (T2wsup-dMRI) Technique  \nTokunori Kimura 1*  \nWe have proposed a T2-based free water suppression diffusion MRI (T2wsup-dMRI) technique to address parameter quantification issues due to cerebrospinal fluid (CSF) partial volume effects (PVEs), using a closed form (CF) algorithm. This study optimizes data patterns in (TE, b-value) space and analyzes algorithms for enhanced accuracy and precision. We simulated noise-added numerical, phantom, and brain MRI data to evaluate relative error and coefficient of variation in quantitative parameters using various data patterns and analysis algorithms (CF and least squares [LSQ] fitting). With 4 minimum data points applied to healthy brain tissue with T2 \u003C 100 ms, the CF algorithm with water volume separation was optimal. For more than 4 points, a smaller b-value with shorter TE combined with 2d single-and bi-exponential LSQ fitting provided the best results. The T2wsup-dMRI technique reduces CSF-PVE artifacts in tissue-specific parameter quantification, enhancing approaches for patient needs, data acquisition, and computing costs.  \nKeywords: cerebrospinal fluid, data pattern, diffusion-weighted imaging, partial volume effects  \nIntroduction  \nDiffusion MRI (dMRI) including diffusion-weighted imaging (DWI), diffusion tensor imaging (DTI) 1 and diffusion tensor tractography (DTT)2 can provide tissue variation biomarkers such as cell density, tissue anisotropy, and microvascular perfusion.3,4 These techniques are widely used, particularly in neurological applications related to brain stroke, tumor characterization, and neurodegenerative diseases. Partial volume effects (PVE)–dependent artifacts occur when cerebrospinal fluid (CSF) is mixed with brain tissues of gray matter (GM) or white matter (WM) within the same voxel. These artifacts complicate the quantification of brain tissue–specific quantitative parameters (Q-parameters) like transverse relaxation time (T2), proton density (PD), and longitudinal relaxation time (T1) in contrast-weighted (CW) images and the qualification of the apparent diffusion coefficient (ADC) (or mean diffusivity [MD]), and fractional anisotropy (FA), and the drawing tractography (DTT) .  \n1Department of Radiological Science, Shizuoka College of Medicalcare Science, Hamamatsu, Shizuoka, Japan  \n*Corresponding author: Department of Radiological Science, Shizuoka College of Medicalcare Science, 2000, Hirakuchi, Hamakita, Hamamatsu, Shizuoka 434- 0041, Japan. Phone: +81-053-585-1551, E-mail: [enocolo.tk@gmail.com](enocolo.tk@gmail.com), [kimura@shiz-med-sci.ac.jp](kimura@shiz-med-sci.ac.jp)  \nThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.  \n©2025 Japanese Society for Magnetic Resonance in Medicine Received: November 19, 2024 | Accepted: March 10, 2025  \nAdditionally, standard synthetic MRI (SynMRI) techniques, which generate synthetic CW images from these quantitative parameter maps (Q-maps), introduce CSFPVE–dependent high-intensity artifacts in fluid-attenuated inversion recovery (FLAIR) and double inversion recovery (DIR) .5–6  \nT2-based free water suppressed MRI (T2wsup-MRI),7 and diffusion MRI (T2wsup-dMRI)8 have been proposed to address these issues by providing free water–suppressed (wsup) quantitative Q-maps while maintaining tissue SNR comparable to the standard (without wsup) Q-maps.  \nAs shown in Appendix, the T2wsup-dMRI technique, based on a 2-compartment signal model, requires a minimum of 4 different points (5 points including T1) .9 This allows the calculation of 4 unknown Q-maps using a simple closedform (CF) algorithm while maintaining the tissue SNR by applying the thresholding (ThVwmin) to wat","cbCaie4GbOhi1cym","https://ap.wps.com/l/cbCaie4GbOhi1cym","pdf",24254957,18,"English","# Introduction\n## Diffusion MRI and tissue biomarkers\n## Partial volume effects and quantification challenges\n# T2wsup-dMRI technical approach\n## Closed-form algorithm and water-volume separation\n## Data patterns in (TE, b-value) space\n## Evaluation using simulated and MRI data\n# Results and optimal conditions\n## Minimum data points and best algorithm choices\n## Comparison with other free-water elimination methods\n# Figures and signal model description\n## 2-compartment DWI signal space","[{\"question\":\"What problem does the T2-based water suppression diffusion MRI (T2wsup-dMRI) technique address?\",\"answer\":\"It addresses parameter quantification errors caused by cerebrospinal fluid partial volume effects when CSF mixes with gray or white matter within the same voxel.\"},{\"question\":\"Which algorithm is used for water-volume separation in the proposed method?\",\"answer\":\"The study uses a closed-form (CF) algorithm that separates water volume and supports computation of tissue-specific Q-maps.\"},{\"question\":\"How many data points are required for the closed-form approach to work optimally?\",\"answer\":\"The results indicate that using 4 minimum data points in healthy brain tissue (with T2 \\u003c 100 ms) makes the CF algorithm with water volume separation optimal; for more than 4 points, a different optimized least-squares strategy performs best.\"}]","Optimization of the Data Pattern and Analysis Algorithm for the T2-based Water Suppression Diffusion MRImaging (T2wsup-dMRI) Technique | PDF",1790708607,45]