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Adult participants (BMI \u003C 30) undergoing enhanced chest CT between Dec 2023 and Sep 2024 were assigned to a control group using 320 mgI/mL at 120 kVp or three low-voltage groups using 320, 270, or 240 mgI/mL at 100 kVp. Two blinded readers assessed acceptable-quality proportions; adverse reactions, including injection-site pain and localized/systemic heat, were recorded. Results showed non-inferior image quality for LCCM groups with fewer heat-related events. The study concluded that 100 kVp chest CECT with LCCMs maintains non-inferior diagnostic image quality while reducing certain adverse sensations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/optimization-of-the-contrast-concentration-for-low-tube-voltage-chest-ct-a-randomized-controlled-trial-with-low-concentration-contrast-media/465319/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/optimization-of-the-contrast-concentration-for-low-tube-voltage-chest-ct-a-randomized-controlled-trial-with-low-concentration-contrast-media/465319.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the primary objective of the trial?","Question",{"text":112,"@type":113},"To determine whether low-concentration contrast media maintain non-inferior image quality in 100 kVp conventional chest CT compared with the standard protocol.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were participants assigned to the groups?",{"text":117,"@type":113},"Adult patients with BMI \u003C 30 undergoing enhanced chest CT were randomized into four groups: a control group at 120 kVp with 320 mgI/mL and three test groups at 100 kVp using 320 mgI/mL, 270 mgI/mL, or 240 mgI/mL.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about image quality and adverse reactions?",{"text":121,"@type":113},"Image quality was non-inferior for the 100 kVp LCCM groups, and injection site pain and heat-related sensations were less frequent in LCCM groups, with systemic heat showing statistical significance.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},465319,1790819951,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","Article  \nOptimization of the Contrast Concentration for  \nLow-Tube-Voltage Chest CT: A Randomized Controlled Trial with Low-Concentration Contrast Media  \nJiho Park 1, Bo Mi Gil 2, Yun-Hyeon Kim 3, Gong Yong Jin 4, Yeon Joo Jeong 5, Jin Mo Goo 6, Suyon Chang 1, Kyongmin Sarah Beck 1 and Jung Im Jung 1, *  \nAcademic Editor: Thomas Frauenfelder  \nReceived: 18 November 2025  \nRevised: 18 December 2025  \nAccepted: 19 December 2025  \nPublished: 25 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 222, Banpo-daero, Seoul 06591, Republic of Korea; [hoyinside@gmail.com](hoyinside@gmail.com) (J.P.); [ohyes723@gmail.com](ohyes723@gmail.com) (S.C.); [sallahbar@gmail.com](sallahbar@gmail.com) (K.S.B.)  \n2 Department of Radiology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, 327 Sosa-ro, Bucheon 14627, Republic of Korea; [xhxhh@catholic.ac.kr](xhxhh@catholic.ac.kr)  \n3 Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, 42 Jebong-ro, Gwangju 61469, Republic of Korea; [yhkim001@jnu.ac.kr](yhkim001@jnu.ac.kr)  \n4 Department of Radiology, Research Institute of Clinical Medicine of Jeonbuk National University, Biomedical Research Institute of Jeonbuk National University Hospital, 20 Geongi-ro, Jeonju 54907, Republic of Korea; [gyjin@jbnu.ac.kr](gyjin@jbnu.ac.kr)  \n5 Department of Radiology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, 20 Geumo-ro, Yangsan 50612, Republic of Korea; [lunar9052@hanmail.net](lunar9052@hanmail.net)  \n6 Department of Radiology, Seoul National University College of Medicine, 101 Daehak-ro, Seoul 03080, Republic of Korea; [jmgoo@snu.ac.kr](jmgoo@snu.ac.kr)  \n* [Correspondence: jijung@catholic.ac.kr](Correspondence: jijung@catholic.ac.kr); Tel.: +82-2-2258-1432  \nAbstract  \nObjective: To evaluate the effect of low-concentration contrast media (LCCMs) on 100 kVp conventional chest CT by comparing the proportions of acceptable-quality scans obtained using various CM concentrations with those obtained using the standard protocol. Materials and Methods: This prospective, multicenter, randomized controlled trial enrolled adult patients with BMI \u003C 30 who underwent enhanced chest CT between December 2023 and September 2024 . Participants were randomly assigned to four groups: one control group (120 kVp, 320 mgI/mL) and three test groups using 100 kVp and standard CM (320 mgI/mL) or LCCMs (270 or 240 mgI/mL) . Non-inferiority was tested based on the proportion of acceptable-quality scans independently assessed by two readers. Adverse reactions, including injection site pain and localized and systemic heat sensations, were recorded. Results: A total of 371 participants (mean age: 66.0, IQR: 58–73 years) were randomized. 100 kVp chest CT with LCCM groups showed non-inferior image quality to the standard protocol (270 mgI/mL: reader 1—98.33% confidence interval [CI]: −4.95, 9.37 and reader 2–98.33% CI: −7.11, 7.21; 240 mgI/mL: reader 1–98.33% CI: −6.44, 8.71 and reader 2–98.33% CI: −11.47, 5.11; all p \u003C 0.001) . Reader 2 reported a lower proportion of acceptable scans in the 320 mgI/mL low-voltage group (p = 0.11), whereas Reader 1 did not find significant inferiority (p = 0.003) . Injection site pain, localized heat, and systemic heat were less frequent in LCCM groups, while systemic heat was only statistically significant (p = 0.003) . Conclusions: Low-tube-voltage (100 kVp) chest CECT using LCCMs yields non-inferior image quality compared with the standard protocol while using conventional concentration contrast media under 100 kVp resulted i","cbCaigtYxAXUwMCX","https://ap.wps.com/l/cbCaigtYxAXUwMCX","pdf",3292326,14,"English","# Abstract\n## Objective\n## Materials and Methods\n## Results\n## Conclusions\n# 1. Introduction\n## Low-dose and low-voltage chest CT trends\n## Need for contrast media optimization at reduced tube voltage\n## Approaches to reducing iodine delivery","[{\"question\":\"What was the primary objective of the trial?\",\"answer\":\"To determine whether low-concentration contrast media maintain non-inferior image quality in 100 kVp conventional chest CT compared with the standard protocol.\"},{\"question\":\"How were participants assigned to the groups?\",\"answer\":\"Adult patients with BMI \\u003c 30 undergoing enhanced chest CT were randomized into four groups: a control group at 120 kVp with 320 mgI/mL and three test groups at 100 kVp using 320 mgI/mL, 270 mgI/mL, or 240 mgI/mL.\"},{\"question\":\"What did the study find about image quality and adverse reactions?\",\"answer\":\"Image quality was non-inferior for the 100 kVp LCCM groups, and injection site pain and heat-related sensations were less frequent in LCCM groups, with systemic heat showing statistical significance.\"}]","Optimization of the Contrast Concentration for Low-Tube-Voltage Chest CT - A Randomized Controlled Trial with Low-Concentration Contrast Media | PDF",1790769474,35]