[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-32101":3,"doc-seo-32101":28},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":19,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"table_of_contents":24,"faqs":25,"seo_title":13,"seo_description":14,"update_tm":26,"read_time":27},32101,549758252649,"Ivy","https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819",8,"Research & Report","Optimization of Ionic Liquid Based Aqueous Two Phase System for Partial Purification of Bacteriocin Like Inhibitory Substance","Bacteriocin-like inhibitory substance (BLIS) shows strong inhibitory activity against oral pathogens, but high purity is required for safe and effective use in oral care products. Ionic liquid-based aqueous two-phase systems (ILATPS) were optimized to recover and purify BLIS from Enterococcus faecium CC2 using response surface methodology (RSM). ILATPS at pH 7, 40°C, and a defined composition achieved a purification factor of 4.406, recovery yield of 67.213%, and partition coefficient of 4.852, with inhibitory activity against Streptococcus mutans.","cbCainOpKHRJc7dD","https://ap.wps.com/l/cbCainOpKHRJc7dD","pdf",2224206,3,1,9,"English","en","# Introduction\n## Oral pathogens and dental caries context\n## BLIS and bacteriocins\n## Purification challenges and rationale for ATPS\n# Methods\n## ILATPS optimization using RSM\n## BLIS identification and activity assessment\n# Results and Discussion\n## Optimal ILATPS conditions and performance metrics\n## BLIS characterization and inhibitory activity","[{\"question\":\"Why is purification of BLIS necessary for oral care applications?\",\"answer\":\"High purity is required to ensure the safety and effectiveness of BLIS when used in oral care products.\"},{\"question\":\"How was the ionic liquid-based aqueous two-phase system (ILATPS) optimized?\",\"answer\":\"Optimization was performed using response surface methodology (RSM) to improve purification of BLIS from Enterococcus faecium CC2.\"},{\"question\":\"What optimal ILATPS conditions and purification performance were reported?\",\"answer\":\"An ILATPS composition at pH 7 and 40°C produced a purification factor of 4.406, a recovery yield of 67.213%, and a partition coefficient of 4.852.\"}]",1780866145,23,{"code":4,"msg":29,"data":30},"ok",{"site_id":31,"language":23,"slug":32,"title":13,"keywords":33,"description":14,"schema_data":34,"social_meta":85,"head_meta":87,"extra_data":89,"updated_unix":26},105,"optimization-of-ionic-liquid-based-aqueous-two-phase-system-for-partial-purification-of-bacteriocin-like-inhibitory-substance","",{"@graph":35,"@context":84},[36,52,67],{"@type":37,"itemListElement":38},"BreadcrumbList",[39,43,47,49],{"item":40,"name":41,"@type":42,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":44,"name":45,"@type":42,"position":46},"https://docshare.wps.com/document/","Document",2,{"item":48,"name":12,"@type":42,"position":19},"https://docshare.wps.com/document/research-report/",{"item":50,"name":13,"@type":42,"position":51},"https://docshare.wps.com/document/optimization-of-ionic-liquid-based-aqueous-two-phase-system-for-partial-purification-of-bacteriocin-like-inhibitory-substance/32101/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":61,"encodingFormat":59,"isAccessibleForFree":62,"interactionStatistic":63},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":40,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-06-11","2026-06-07",true,{"@type":64,"interactionType":65,"userInteractionCount":19},"InteractionCounter",{"@type":66},"ViewAction",{"@type":68,"mainEntity":69},"FAQPage",[70,76,80],{"name":71,"@type":72,"acceptedAnswer":73},"Why is purification of BLIS necessary for oral care applications?","Question",{"text":74,"@type":75},"High purity is required to ensure the safety and effectiveness of BLIS when used in oral care products.","Answer",{"name":77,"@type":72,"acceptedAnswer":78},"How was the ionic liquid-based aqueous two-phase system (ILATPS) optimized?",{"text":79,"@type":75},"Optimization was performed using response surface methodology (RSM) to improve purification of BLIS from Enterococcus faecium CC2.",{"name":81,"@type":72,"acceptedAnswer":82},"What optimal ILATPS conditions and purification performance were reported?",{"text":83,"@type":75},"An ILATPS composition at pH 7 and 40°C produced a purification factor of 4.406, a recovery yield of 67.213%, and a partition coefficient of 4.852.","https://schema.org",{"og:url":50,"og:type":86,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":88,"canonical":50},"index,follow",{"doc_id":7,"site_id":31}]