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TAVI procedures from July 2013 to December 2023 were compared between patients treated before January 2019 and those treated after guideline implementation. Primary endpoints focused on mortality and major complications, while secondary endpoints included procedural success and device-related complications. The implementation period showed lower one-year mortality and reduced pacemaker and stroke rates, alongside consistently high procedural success.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/op75-impact-of-updated-guidelines-on-transcatheter-aortic-valve-implantation-outcomes-in-brazil-a-decadelong-retrospective-study-study/445580/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/op75-impact-of-updated-guidelines-on-transcatheter-aortic-valve-implantation-outcomes-in-brazil-a-decadelong-retrospective-study-study/445580.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the main purpose of the OP75 study?","Question",{"text":113,"@type":114},"To assess the impact of the 2018 update to TAVI clinical guidelines on patient outcomes in Brazil using a decade-long retrospective cohort.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were patients grouped in the study?",{"text":118,"@type":114},"Patients were divided into two cohorts: those treated before January 2019 and those treated after January 2019, aligned with guideline implementation.",{"name":120,"@type":111,"acceptedAnswer":121},"What outcome improvements were reported after guideline implementation?",{"text":122,"@type":114},"One-year mortality decreased and rates of pacemaker implantation and stroke were reduced, while procedural success remained high in both cohorts.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},445580,1791034030,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":81,"preview_page_count":4},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","OP75 Impact Of Updated Guidelines On Transcatheter Aortic Valve Implantation Outcomes In Brazil: A DecadeLong Retrospective Study  \nMarcus Borin, Mariana Michel Barbosa,  \nCarina Rejane Martins, Daniel Pitchon dos Reis, Geraldo José Coelho Ribeiro, Júlia Teixeira Tupinambás, Karina de Castro Zocrato,  \nLélia Maria de Almeida Carvalho, Marcela Pinto de Freitas,  \nMaria da Glória Cruvinel Horta, Mariza Cristina Torres Talim, Sergio Adriano Loureiro Bersan and  \nSilvana Marcia Bruschi Kelles ([silvanakelles@gmail.com](silvanakelles@gmail.com))   \nIntroduction: Transcatheter aortic valve implantation (TAVI) has revolutionized the treatment of severe aortic stenosis, compared with more invasive surgical aortic valve replacement (SAVR) . Outcomes after device advancements and the landmark 2018 update to TAVI clinical guidelines were analyzed in a 10-year cohort study conducted by a Brazilian health maintenance organization.  \nMethods: The study analyzed TAVI procedures performed from July 2013 to December 2023 in a Brazilian health maintenance organization. Patients were grouped into two cohorts: those treated before January 2019 and those treated after January 2019, aligning with the implementation of the updated guidelines. Data on patient demographics, procedural details, and clinical outcomes were collected from institutional databases. Primary outcomes included rates of mortality and major complications, while secondary outcomes encompassed rates of procedural success and device-related complications. Statistical comparisons were conducted using chi-square and t-tests, with significance set at p\u003C0.05 .  \nResults: The study included 325 patients, with 56 treated before and 269 after the guideline update. There was no difference in median age (84 years) between the two cohorts, and 58 percent were female. After guideline implementation, a shift to self-expanding valves resulted in reduced rates of pacemaker implantation (28.6 to 18.2%; p=0.03) and stroke(8.9to5.6%;p=0.2). The one-year mortality rate decreased from 25 to 14.9 percent, reflecting significant improvements in clinical outcomes. Procedural success rates exceeded 98 percent in both cohorts, demonstrating the reliability of TAVI in routine practice. Conclusions: The implementation of updated procedural protocols in 2018 led to significant improvements in TAVI outcomes for patients with similar risk profiles. These findings underscore the importance of evidence-based practice and continuous technological advancements in optimizing patient care for severe aortic stenosis. Future studies should focus on long-term outcomes and durability of TAVI devices.  \nOP76 Direct Costs Associated With HER2+ Breast Cancer Care In A Colombian Healthcare Institution: A Real-WorldEvidence Study  \nManuel González, Sandra Arauchan, Sergio Beltran, José Lobatón, Danis Rojas, Javier Ospina and Daniel Samacá ([daniel.samaca@roche.com](daniel.samaca@roche.com))  \nIntroduction: Economic restrictions can affect breast cancer healthcare attention; therefore, it is essential to identify the main economic factors that impact the health system’s budget. This study identified and quantified monetarily the events generating direct costs associated with the care of HER2+ breast cancer according to stage of the disease in a Colombian healthcare institution.  \nMethods: This retrospective observational study included women over 18 years of age with a diagnosis of HER2+ breast cancer identified through International Classification of Diseases,10thRevision codes present in medical records between January 2018 and December 2022 . Resources were organized into the categories of laboratory tests, medical consultations, procedures, diagnostic imaging, supplies, radiotherapy, and medications. The monetary valuation was carried out using the UPC Sufficiency, RIPS, SOAT, and SISMED prices databases for 2023 . A micro-costing technique and a third-payer perspective were employed. The average and total care costs by b","cbCaif3IJ4NJrMR4","https://ap.wps.com/l/cbCaif3IJ4NJrMR4","pdf",32052,"English","# Introduction\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What was the main purpose of the OP75 study?\",\"answer\":\"To assess the impact of the 2018 update to TAVI clinical guidelines on patient outcomes in Brazil using a decade-long retrospective cohort.\"},{\"question\":\"How were patients grouped in the study?\",\"answer\":\"Patients were divided into two cohorts: those treated before January 2019 and those treated after January 2019, aligned with guideline implementation.\"},{\"question\":\"What outcome improvements were reported after guideline implementation?\",\"answer\":\"One-year mortality decreased and rates of pacemaker implantation and stroke were reduced, while procedural success remained high in both cohorts.\"}]","OP75 Impact Of Updated Guidelines On Transcatheter Aortic Valve Implantation Outcomes In Brazil - A DecadeLong Retrospective Study - study | PDF",1790712418]