[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-380818-105":59,"doc-detail-380818-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","one-patient-with-4-different-primary-cancers-a-case-report","One Patient With 4 Different Primary Cancers - A Case Report","","Medicine development, particularly in oncology, can prolong survival, but it also increases the likelihood of multiple cancers. The occurrence of four primary cancers arising independently at four different sites is extremely uncommon. This case report describes a 63-year-old woman diagnosed with thyroid cancer in 2018, right colon cancer in 2019, left renal pelvis cancer in 2020, and bladder cancer in April 2022. Regular follow-up enabled early detection and appropriate treatment, and ongoing monitoring is emphasized.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/one-patient-with-4-different-primary-cancers-a-case-report/380818/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/one-patient-with-4-different-primary-cancers-a-case-report/380818.png","ImageObject",300,407,{"name":92,"@type":93},"dhado","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is having four primary cancers in different sites noteworthy?","Question",{"text":112,"@type":113},"Four independent primary cancers in four different sites is extremely rare. The case highlights the need to remain alert for additional primary malignancies even after cancer survivorship.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What cancers were diagnosed in this patient and when?",{"text":117,"@type":113},"The patient was diagnosed with thyroid cancer in 2018, right colon cancer in 2019, left renal pelvis cancer in 2020, and bladder cancer in April 2022.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the patient managed after each diagnosis?",{"text":121,"@type":113},"The report describes timely investigation and appropriate treatment for each malignancy, supported by close regular follow-up, leading to early detection and stable health during continued monitoring.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},380818,1790636449,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},5909893218464,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","One Patient With 4 Different Primary Cancers: A Case Report  \nDung Thi Nguyen1 , Lan Mai Nguyen1, Thang Le Phan2 and Quang Vinh Bui3  \n1On-Demand Gastrointestinal Medical Oncology Department, Hanoi Oncology Hospital, Hanoi, Vietnam. 2On-Demand Surgery Department, Hanoi Oncology Hospital, Hanoi, Vietnam. 3 Board of Directors, Hanoi Oncology Hospital, Hanoi, Vietnam.  \nClinical Medicine Insights: Case Reports  \nVolume 16: 1–6  \n© The Author(s) 2023  \nArticle reuse guidelines: [sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/11795476221150597](DOI: 10.1177/11795476221150597)  \n|  |  |\n| --- | --- |\n| ABSTRACT\u003Cbr>BACkgROunD: The development of medicine, especially in oncology, has been helping prolong the cancer patients’ survival, but also leads to increasing the possibility of getting multiple cancers . However, the possibility of getting 4 primary cancers in 4 different sites is extremely rare.\u003Cbr>CASe PReSenTATiOn: A 63-year-old female patient was diagnosed with thyroid cancer in 2018, and then with right colon cancer in 2019. In 2020, this patient was diagnosed with left renal pelvis cancer, and most recently, in April 2022, she was hospitalized with bladder cancer diagnosis . Thanks to being closely and regularly followed-up, her malignancies had been detected early and treated suitably. Her health remains stable now and she is under following-up.\u003Cbr>COnCluSiOn: Even though developing another primary cancer in a cancer survivor is not uncommon now and has the tendency to increase, a patient having 4 primary cancers in 4 different sites is still extremely rare and should be noticed, further followed up and investigated. Cancer patients and survivors need to be followed-up regularly, to early detect not only the progression or recurrence but also the second cancer (if it exists), to get timely and suitable treatment.\u003Cbr>keyWORDS: Multiple primary cancers, quadruple cancers, cancer survivor |  |\n| ReCeiVeD: August 17, 2022. ACCePTeD: December 23, 2022.\u003Cbr>TyPe: Case Report\u003Cbr>FunDing: The author(s) received no financial support for the research, authorship, and/or publication of this article. | DeClARATiOn OF COnFliCTing inTeReSTS: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.\u003Cbr>CORReSPOnDing AuTHOR: Dung Thi Nguyen, Add. Hanoi Oncology Hospital, 42A Thanh Nhan Street, Hai Ba Trung District, Hanoi 100000, Vietnam. Email. dungnt@ [bvubhn.vn](bvubhn.vn) |\n\nIntroduction  \nCancer patients have a 20% higher risk of developing another primary cancer than the general population, and the second primary cancer has become the leading cause of death among patients with prolonged cancer survival.1 Multiple primary cancers are defined as 2 or more malignancies that arise independently of each other in the same or different organs, while excluding metastatic sites of primary malignancies.2 The incidence of multiple primary cancers ranges from 3% to 5%; most of them are double cancers, whereas quadruple primary neoplasms are extremely rare with only about 0.3% of all malignant tumors.3 Here we reported a rare case that a patient has 4 consecutive malignancies in 4 different sites. Based on our literature review, there were only 9 such cases had been reported so far, as presented in the following  \nCase Presentation  \nThe patient is a 63-year-old female who had no significant medical or family history. She was admitted to our hospital in Marth 2018 with the diagnosis of right thyroid carcinoma on multinodular goiter after ultrasonography suggested a malignant lesion in the right lobe of the thyroid gland, and cytology of a fine-needle aspiration specimen revealed a follicular neoplasm.Thyroidectomy was then performed.The post-operative pathological resulted as pT3N0M0 stage I papillary carcinoma. One month after surgery, a regimen of 50mCI dose ofI131 was administered. After completing","cbCaisgX7FmxNz4P","https://ap.wps.com/l/cbCaisgX7FmxNz4P","pdf",2232318,"English","# Abstract\n# Introduction\n# Case Presentation\n## Thyroid cancer diagnosis and treatment\n## Colon cancer diagnosis and treatment\n## Review of reported quadruple-cancer cases\n# Funding and conflict of interest\n# Corresponding author information","[{\"question\":\"Why is having four primary cancers in different sites noteworthy?\",\"answer\":\"Four independent primary cancers in four different sites is extremely rare. The case highlights the need to remain alert for additional primary malignancies even after cancer survivorship.\"},{\"question\":\"What cancers were diagnosed in this patient and when?\",\"answer\":\"The patient was diagnosed with thyroid cancer in 2018, right colon cancer in 2019, left renal pelvis cancer in 2020, and bladder cancer in April 2022.\"},{\"question\":\"How was the patient managed after each diagnosis?\",\"answer\":\"The report describes timely investigation and appropriate treatment for each malignancy, supported by close regular follow-up, leading to early detection and stable health during continued monitoring.\"}]","One Patient With 4 Different Primary Cancers - A Case Report | PDF",1790242252,15]