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Nuño-Guzmán 6,12,  \nMartha-Cecilia Velázquez-Flores 1,13, Miguel-Ricardo Ochoa-Plascencia 2,6, María-Ivette Muciño-Hernández 2,6, Mario-Alberto Isiordia-Espinoza 14, Mario-Alberto Mireles-Ramírez 15 and Eduardo Hernández-Salazar 16  \nCitation: Sat-Muñoz, D.; BalderasPeña, L.-M.-A.; Gómez-Sánchez, E.; Martínez-Herrera, B.-E.; TrujilloHernández, B.; Quiroga-Morales, L.-A.; Salazar-Páramo, M.; DávalosRodríguez, I.-P.; Nuño-Guzmán, C.M.; Velázquez-Flores, M.-C.; et al.  \nOnco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives. Int. J. Mol. Sci. 2024, 25, 9979. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms25189979  \nAcademic Editors: Marko Tarle and Ivica Lukši´c  \nReceived: 16 July 2024  \nRevised: 6 September 2024  \nAccepted: 14 September 2024  \nPublished: 16 September 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Departamento de Morfología, Centro Universitario de Ciencis de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico; [c.velazquez@academicos.udg.mx](c.velazquez@academicos.udg.mx)  \n2 Cuerpo Académico UDG-CA-874, Ciencias Morfológicas en el Diagnóstico y Tratamiento de la Enfermedad, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico; [eduardo.gsanchez@academicos.udg.mx](eduardo.gsanchez@academicos.udg.mx) (E.G.-S.); [miguel.oplascencia@academicos.udg.mx](miguel.oplascencia@academicos.udg.mx) (M.-R.O.-P.); [ivette.mucino@academicos.udg.mx](ivette.mucino@academicos.udg.mx) (M.-I.M.-H.)  \n3 Unidad Médica de Alta Especialidad (UMAE), Departamento Clínico de Cirugía Oncológica, Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Mexico  \n4 Comité de Tumores de Cabeza y Cuello, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Mexico  \n5 Unidad de Investigación Biomédica 02, Unidad Médica de Alta Especialidad (UMAE), Hospital de Especialidades (HE), Centro Médico Nacional de Occidente (CMNO), Instituto Mexicano del Seguro Social (IMSS), Guadalajara 44340, Mexico  \n6 División de Disciplinas Clínicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Mexico; [carlosnunoguzman@hotmail.com](carlosnunoguzman@hotmail.com)  \n7 Departamento de Nutrición y Dietética, Hospital General de Zona \\#1, Instituto Mexicano del Seguro Social, OOAD Aguascalientes, Boulevard José María Chavez \\#1202, Fracc, Lindavista, Aguascalientes 20270, Mexico; [bren.mtzh16@gmail.com](bren.mtzh16@gmail.com)  \n8 Posgrado en Ciencias Médicas, Universidad de Colima, Colima 28040, Mexico; [trujillobenjamin@hotmail.com](trujillobenjamin@hotmail.com)  \n9 Unidad Académica de Ciencias de la Salud, Clínica de Rehabilitación y Alto Rendimiento ESPORTIVA, Universidad Autónoma de Guadalajara, Zapopan 45129, Mexico; [luisquiroga@hotmail.com](luisquiroga@hotmail.com)  \n10 Departamento de Fisiología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Academia de Inmunología, Guadalajara 44340, Mexico; [mario.sparamo@academicos.udg.mx](mario.sparamo@academicos.udg.mx)  \n11 Departamento de Biología Molec","cbCaihpi1Bo1dUPZ","https://ap.wps.com/l/cbCaihpi1Bo1dUPZ","pdf",814436,34,"English","# Abstract\n## Key disease background\n## Scope of gene-focused review\n## Developmental and oncogenic implications","[{\"question\":\"What disease is the review focused on?\",\"answer\":\"The review focuses on head and neck squamous cell carcinoma (H\\u0026NSCC), described as a complex anatomic, biological, and genetic disease.\"},{\"question\":\"What is the specific scope regarding genes?\",\"answer\":\"The review limits its search and description to genes implicated in the onco-ontogeny of derivatives from the first pharyngeal arch.\"},{\"question\":\"Why is the first pharyngeal arch relevant to the discussion?\",\"answer\":\"The first pharyngeal arch is used as a developmental origin framework to connect oncogenesis-related genes with cancer development and progression.\"}]","Onco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives - Review | PDF",1789992689,86]