[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333074-105":59,"doc-detail-333074-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","omics-studies-of-tumor-cells-under-microgravity-conditions-review","Omics Studies of Tumor Cells under Microgravity Conditions - Review","","Cancer is a group of diseases marked by abnormal cell growth, expansion, progression, and metastasis, with malignant tumors causing high morbidity and mortality. Although cancer research has advanced knowledge of underlying mechanisms, key aspects remain unclear. High-throughput omics and bioinformatics have helped uncover parts of these mechanisms. The review emphasizes that orbit exposure produces biochemical and molecular changes in human cancer cells, mainly driven by microgravity (µg). It surveys omics studies from genetic to metabolomic analyses using real or simulated µg, covering multiple tumor types and biological processes to support new cancer strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/omics-studies-of-tumor-cells-under-microgravity-conditions-review/333074/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/omics-studies-of-tumor-cells-under-microgravity-conditions-review/333074.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does microgravity play in cancer cell biology?","Question",{"text":112,"@type":113},"Microgravity exposure (µg) creates conditions not reachable on Earth, leading to biochemical and molecular biological changes in human cancer cells. These changes affect signaling pathways and processes involved in growth and metastasis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which omics levels are covered in the review?",{"text":117,"@type":113},"The review focuses on genetic, transcriptional, epigenetic, proteomic, and metabolomic studies. It includes tumor cells exposed to real space conditions or to simulated µg using simulation devices.",{"name":119,"@type":110,"acceptedAnswer":120},"How does space research influence biological processes related to cancer?",{"text":121,"@type":113},"Space research impacts multiple cancer-related processes such as proliferation, apoptosis, cell survival, adhesion, migration, cytoskeleton dynamics, extracellular matrix changes, focal adhesion signaling, and growth factors.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333074,1790389468,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","Review  \nOmics Studies of Tumor Cells under Microgravity Conditions  \nJenny Graf 1, Herbert Schulz 1,2, Markus Wehland 1,2, Thomas J. Corydon 3,4, Jayashree Sahana 3, Fatima Abdelfattah 1, Simon L. Wuest 5, Marcel Egli 5,6, Marcus Krüger 1,2, Armin Kraus 2,7, Petra M. Wise 1,2,8, Manfred Infanger 2,7 and Daniela Grimm 1,2,3, *  \nCitation: Graf, J.; Schulz, H.; Wehland, M.; Corydon, T.J.; Sahana, J.;  \nAbdelfattah, F.; Wuest, S.L.; Egli, M.; Krüger, M.; Kraus, A.; et al. Omics Studies of Tumor Cells under Microgravity Conditions. Int. J. Mol. Sci. 2024, 25, 926. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms25020926](10.3390/ijms25020926)  \nAcademic Editor: Nam Deuk Kim  \nReceived: 14 December 2023  \nRevised: 7 January 2024  \nAccepted: 8 January 2024  \nPublished: 11 January 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Department of Microgravity and Translational Regenerative Medicine, Otto von Guericke University, 39106 Magdeburg, Germany; [jenny.graf@med.ovgu.de](jenny.graf@med.ovgu.de) (J.G.); [herbert.schulz@med.ovgu.de](herbert.schulz@med.ovgu.de) (H.S.); [markus.wehland@med.ovgu.de](markus.wehland@med.ovgu.de) (M.W.); fatima.abdelfattah@med.ovgu.de (F.A.); [marcus.krueger@med.ovgu.de](marcus.krueger@med.ovgu.de) (M.K.); [wisepetra@gmail.com](wisepetra@gmail.com) (P.M.W.)  \n2 Research Group “Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt-und Schwerelosigkeitsbedingungen”(MARS), Otto von Guericke University, 39106 Magdeburg, Germany; [armin.kraus@med.ovgu.de](armin.kraus@med.ovgu.de) (A.K.); [manfred.infanger@med.ovgu.de](manfred.infanger@med.ovgu.de) (M.I.)  \n3 Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark; [corydon@biomed.au.dk](corydon@biomed.au.dk) (T.J.C.); [jaysaha@biomed.au.dk](jaysaha@biomed.au.dk) (J.S.)  \n4 Department of Ophthalmology, Aarhus University Hospital, 8200 Aarhus N, Denmark  \n5 Space Biology Group, Institute of Medical Engineering, Lucerne University of Applied Sciences and Arts, 6052 Hergiswil, Switzerland; [marcel.egli@hslu.ch](marcel.egli@hslu.ch) (M.E.)  \n6 National Center for Biomedical Research in Space, Innovation Cluster Space and Aviation (UZH Space Hub), University Zurich, 8006 Zurich, Switzerland  \n7 Clinic for Plastic, Aesthetic and Hand Surgery, Medical Faculty, University Hospital Magdeburg, Otto von Guericke University, 39120 Magdeburg, Germany  \n8 The Saban Research Institute, Children’s Hospital Los Angeles, University of Southern California, 4650 Sunset Blvd, Los Angeles, CA 90027, USA  \n* Correspondence: [dgg@biomed.au.dk](dgg@biomed.au.dk)  \nAbstract: Cancer is defined as a group of diseases characterized by abnormal cell growth, expansion, and progression with metastasis. Various signaling pathways are involved in its development. Malignant tumors exhibit a high morbidity and mortality. Cancer research increased our knowledge about some of the underlying mechanisms, but to this day, our understanding of this disease is unclear. High throughput omics technology and bioinformatics were successful in detecting some of the unknown cancer mechanisms. However, novel groundbreaking research and ideas are necessary. A stay in orbit causes biochemical and molecular biological changes in human cancer cells which are first, and above all, due to microgravity (µg) . The µg-environment provides conditions that are not reachable on Earth, which allow researchers to focus on signaling pathways controlling cell growth and metastasis. Cancer research in space already demonstrated how cancer cell-exposure to µg influenced several biological processes being involved in cancer. This novel approach has the potential to fight","cbCaiinndbGVZPQe","https://ap.wps.com/l/cbCaiinndbGVZPQe","pdf",4066978,48,"English","# Abstract\n## Introduction","[{\"question\":\"What role does microgravity play in cancer cell biology?\",\"answer\":\"Microgravity exposure (µg) creates conditions not reachable on Earth, leading to biochemical and molecular biological changes in human cancer cells. These changes affect signaling pathways and processes involved in growth and metastasis.\"},{\"question\":\"Which omics levels are covered in the review?\",\"answer\":\"The review focuses on genetic, transcriptional, epigenetic, proteomic, and metabolomic studies. It includes tumor cells exposed to real space conditions or to simulated µg using simulation devices.\"},{\"question\":\"How does space research influence biological processes related to cancer?\",\"answer\":\"Space research impacts multiple cancer-related processes such as proliferation, apoptosis, cell survival, adhesion, migration, cytoskeleton dynamics, extracellular matrix changes, focal adhesion signaling, and growth factors.\"}]","Omics Studies of Tumor Cells under Microgravity Conditions - Review | PDF",1790000728,121]