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This open-access review evaluates olive oil and its phytochemicals, especially oleuropein and hydroxytyrosol, focusing on antioxidant capacity and their roles in cancer prevention and treatment. Searches across Google Scholar, PubMed, and Web of Science summarize linked biomarkers across cancers and describe modulation of tumor suppressor genes, oncogene downregulation, and signaling pathways including PI3K/AKT/mTOR, Wnt/β-catenin, and MAPK.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/olive-oil-polyphenols-a-promising-approach-for-cancer-prevention-and-therapy/369847/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/olive-oil-polyphenols-a-promising-approach-for-cancer-prevention-and-therapy/369847.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What are the main olive oil polyphenols discussed for cancer prevention and therapy?","Question",{"text":112,"@type":113},"The review highlights oleuropein and hydroxytyrosol as key phytochemicals in olive oil that are studied for their potential anticancer effects.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which cancer-related biomarkers does the review connect to specific cancer types?",{"text":117,"@type":113},"It mentions biomarkers associated with particular cancers, including markers linked to breast cancer, thyroid cancer, and colorectal cancer, such as HER2 and MET for breast cancer and GLUT1/GLUT4 and PD-1/PD-L1 for colorectal cancer.",{"name":119,"@type":110,"acceptedAnswer":120},"How does olive oil polyphenol activity act on cellular pathways according to the review?",{"text":121,"@type":113},"The review describes effects such as upregulating tumor suppressor genes, downregulating oncogenes, and modulating pathways including PI3K/AKT/mTOR, Wnt/β-catenin, and MAPK.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},369847,1790640715,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Food Science & Nutrition  \nREVIEW  OPEN ACCESS   \nOlive Oil Polyphenols: A Promising Approach for Cancer Prevention and Therapy  \nMuhammad Junaid Anwar1 | Muhammad Hammad Anwar2 | Muhammad Imran3 | Ahmad Mujtaba Noman4 | Muzzamal Hussain5  | Hassan Raza1  | Hagar M. Mohamed6,7  | Gamal A. Mohamed8 | Sabrin R. M. Ibrahim9,10 | Tadesse Fenta Yehuala11  | Suliman A. Alsagaby12 | Waleed Al Abdulmonem13 | Mohamed A. Abdelgawad14 |  \nEhab M. Mostafa15 | Mohammed M. Ghoneim16 | Samy Selim17   \n1Department of Food Science and Technology, Faculty of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan | 2Department of Food Science and Technology, Faculty of Food and Home Science, Muhammad Nawaz Sharif University of Agriculture Multan, Multan,  \nPakistan | 3Department of Food Science and Technology, University of Narowal, Narowal, Pakistan | 4Department of Human Nutrition, Faculty of Food Science and Nutrition, Bahauddin Zakariya University, Multan, Pakistan | 5Department of Food Sciences, Government College University Faisalabad, Faisalabad, Pakistan | 6Department of Medical Laboratory Analysis, College of Medical & Health Sciences, Liwa University, Abu Dhabi, UAE | 7Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt | 8Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia | 9Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah, Saudi Arabia | 10Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, Egypt | 11Faculty of Chemical and Food Engineering, Bahir Dar Institute of Technology, Bahir Dar University, Bahir Dar City, Ethiopia | 12Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, AL-Majmaah, Saudi Arabia | 13Department of Pathology, College of Medicine, Qassim University, Buraidah, Kingdom of Saudi Arabia | 14Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia | 15Department of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka, Saudi Arabia | 16Department of Pharmacy  \nPractice, College of Pharmacy, AlMaarefa University, Ad Diriyah, Saudi Arabia | 17Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia  \nCorrespondence: Muzzamal Hussain ([muzzamalhussain24@gcuf.edu.pk](muzzamalhussain24@gcuf.edu.pk)) | Sabrin R. M. Ibrahim ([sabrin.ibrahim@bmc.edu.sa](sabrin.ibrahim@bmc.edu.sa)) | Tadesse Fenta Yehuala ([tadeyfenta@gmail.com](tadeyfenta@gmail.com))  \nReceived: 29 May 2025 | Revised: 21 August 2025 | Accepted: 31 August 2025  \nFunding: The authors received no specific funding for this work.  \nKeywords: hydroxytyrosol | lung cancer | oleuropein breast cancer | olive oil | polyphenols | STAT3  \nABSTRACT  \nCancer is emerging as a leading cause of death globally. Considering the disease burden, scientists are working to develop various strategies by exploring natural sources for cancer treatment. The use of olive oil (OO) and its phytochemicals, specifically oleuropein and hydroxytyrosol (HT), as a remedy against various types of cancer is gaining attention among scientists and researchers. The current review aimed to highlight the antioxidant potential and summarize the various pathways and markers involved in the prevention and treatment of different human cancers. The databases, including Google Scholar, PubMed, and Web of Science, were searched to collect relevant data. The studies showed that some markers are specifically linked to particular types of cancers (such as 27-OHC, ATF-2, TNFRSF10B, HER2, and MET, which are linked to breast cancer; iNOS and NO, which are linked to thyroid cancer; GLUT1 and GLUT4, HIF-1α, MCT4, PKM2, PD-1, PD-L1, and CTLA-4, which are linked to colorectal cancer) . Olive oil is involved in the management of these markers to prevent ","cbCaieT1iK2gurMc","https://ap.wps.com/l/cbCaieT1iK2gurMc","pdf",815617,18,"English","# Introduction\n## Olive oil and phytochemical rationale\n# Abstract\n## Antioxidant potential and mechanisms\n# Literature search and evidence summary\n## Biomarkers and signaling pathways\n# Conclusions and future directions","[{\"question\":\"What are the main olive oil polyphenols discussed for cancer prevention and therapy?\",\"answer\":\"The review highlights oleuropein and hydroxytyrosol as key phytochemicals in olive oil that are studied for their potential anticancer effects.\"},{\"question\":\"Which cancer-related biomarkers does the review connect to specific cancer types?\",\"answer\":\"It mentions biomarkers associated with particular cancers, including markers linked to breast cancer, thyroid cancer, and colorectal cancer, such as HER2 and MET for breast cancer and GLUT1/GLUT4 and PD-1/PD-L1 for colorectal cancer.\"},{\"question\":\"How does olive oil polyphenol activity act on cellular pathways according to the review?\",\"answer\":\"The review describes effects such as upregulating tumor suppressor genes, downregulating oncogenes, and modulating pathways including PI3K/AKT/mTOR, Wnt/β-catenin, and MAPK.\"}]","Olive Oil Polyphenols: A Promising Approach for Cancer Prevention and Therapy | PDF",1790184842,45]