[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-430352-105":59,"doc-detail-430352-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","older-age-is-not-an-independent-predictor-of-syncope-recurrence-following-cardioneuroablation-for-reflex-syncope","Older age is not an independent predictor of syncope recurrence following cardioneuroablation for reflex syncope","","Cardioneuroablation (CNA) is evaluated for reflex syncope, focusing on whether older age determines the risk of syncope recurrence after treatment. This prospective observational single-center study enrolled consecutive patients with cardioinhibitory reflex syncope who completed at least one year of follow-up after bi-atrial CNA using anatomical and mapping guidance. Among 209 patients, most remained free of recurrence and syncope burden decreased substantially, while age was not an independent predictor. Higher recurrence and weaker burden reduction were observed particularly in patients over 60 years, with pacing needs increasing with age.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/older-age-is-not-an-independent-predictor-of-syncope-recurrence-following-cardioneuroablation-for-reflex-syncope/430352/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/older-age-is-not-an-independent-predictor-of-syncope-recurrence-following-cardioneuroablation-for-reflex-syncope/430352.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s primary goal regarding age and CNA outcomes?","Question",{"text":112,"@type":113},"To examine CNA efficacy according to age and other demographic and clinical variables, assessing whether age predicts syncope recurrence after treatment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What proportion of patients remained free from syncope recurrence during follow-up?",{"text":117,"@type":113},"During a median follow-up of 27 months, 166 of 209 patients (79.4%) remained free from syncope recurrence.",{"name":119,"@type":110,"acceptedAnswer":120},"Was age an independent predictor of syncope recurrence after cardioneuroablation?",{"text":121,"@type":113},"No. Univariate analysis linked age ≥60 years with recurrence, but age was not an independent variable predicting the outcome.",{"name":123,"@type":110,"acceptedAnswer":124},"How did pacemaker implantation relate to patient age after CNA?",{"text":125,"@type":113},"Six patients received pacemakers during follow-up, and all were older than 50 years; the need for permanent pacing increased with age starting from 55 years.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},430352,1790716998,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","Journal of Interventional Cardiac Electrophysiology (2026) 69:71–79  \n[https://doi.org/10.1007/s10840-025-02139-z](https://doi.org/10.1007/s10840-025-02139-z)  \nORIGINAL RESEARCH  \nOlder age is not an independent predictor of syncope recurrence following cardioneuroablation for reflex syncope  \nPiotr Kulakowski1 · Agnieszka Sikorska1 · Tomasz Krynski1 · Michał Niedzwiedz1 · Malgorzata Soszynska1 · Jakub Baran1 · Roman Piotrowski1  \nReceived: 1 June 2025 / Accepted: 2 September 2025 / Published online: 23 September 2025 © The Author(s) 2025  \nAbstract  \nBackground Cardioneuroablation (CNA) is a promising tool to treat reflex syncope; however, optimal age cut-off values to undergo CNA have not been established.  \nMethods This is a prospective observational single-center study which included all consecutive patients with cardioinhibitory reflex syncope treated with CNA who completed at least 1 year of follow-up. Bi-atrial CNA was performed using anatomical approach with the use of electro-anatomical mapping system, intracardiac echocardiography and extracardiac vagal stimulation.  \nResults The study group consisted of 209 patients (mean age 39.5 ± 13.6, 121 (58%) females). During a median follow-up of 27 months, 166 (79.4%) patients remained free from syncope recurrence, and syncope burden was significantly reduced (6.67 syncope/year vs. 0.26 syncope/year, p = 0.00001) . Univariate analysis showed that hypertension, number of syncopal episodes, and age ≥ 60 years were associated with syncope recurrence; however, age was not an independent variable predicting the outcome. There was no significant difference in the outcome between patients aged \u003C 40 vs. ≥ 40 or \u003C 50 vs. ≥ 50 years. The reduction of syncope burden was significant in younger age groups but not in patients aged ≥ 60 years. During follow-up, six patients received pacemaker—all were >50 years old.  \nConclusions Age is not an independent predictor ofCNA efficacy; however, patients aged >60 years, particularly those with concomitant hypertension and a high number of syncopal episodes, tend to have higher syncope recurrence and less reduction in syncope burden than younger people. The need for permanent pacing due to ineffective CNA increases with age, starting from 55 years.  \nKeywords Cardioneuroablation · Syncope · Age · Reflex  \n1 Introduction  \nCargdioneuroablation (CNA) is a promising tool to treat reflex syncope [1]; however, optimal age cut-off values for selecting the best candidates have not been yet established. The ESC guidelines on syncope [2] and cardiac pacing [3] recommend pacemaker implantation in those aged >40 years. The more recent review papers suggest more liberal approach, indicating that in patients aged 40–60 years, individualized approach is advocated [4, 5], whereas in the 2024  \n􀀍 Agnieszka Sikorska [sikorska.agnieszka.anna@gmail.com](sikorska.agnieszka.anna@gmail.com)  \n1 Department of Cardiology, Centre of Postgraduate Medical Education , Grochowski Hospital, Warsaw, Poland  \nEHRA statement on CNA, the suggested age cut-off was set at 60 years [6]. However, recently published studies dealing with this topic showed divergent results [7–14] .  \n1.1 Aim  \nTo examine CNA efficacy according to age and other demographic and clinical variables.  \n2 Methods  \nPatients This is a prospective observational single-center study which included all consecutive patients treated with CNA in our center from 2016 who completed at least 1 year of follow-up. Redo procedures were not included in  \nthis analysis. All patients gave written informed consent to undergo CNA and to use their clinical and demographic data for research purposes (Ethics Committee approvals \\# 113/2018, 116/2018, 89/2021) . In our center, patients are offered CNA when they have (i) syncope with ECG-documented spontaneous or tilt-induce asystolic (>3 s) reflex syncope due to functional sinus arrest or atrio-ventricular block (AVB) or (ii) presyncope only, however, with very frequent and disab","cbCain3hhBsDDUGx","https://ap.wps.com/l/cbCain3hhBsDDUGx","pdf",1113420,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# 1 Introduction\n## 1.1 Aim\n# 2 Methods\n## Patients\n## Cardioneuroablation","[{\"question\":\"What was the study’s primary goal regarding age and CNA outcomes?\",\"answer\":\"To examine CNA efficacy according to age and other demographic and clinical variables, assessing whether age predicts syncope recurrence after treatment.\"},{\"question\":\"What proportion of patients remained free from syncope recurrence during follow-up?\",\"answer\":\"During a median follow-up of 27 months, 166 of 209 patients (79.4%) remained free from syncope recurrence.\"},{\"question\":\"Was age an independent predictor of syncope recurrence after cardioneuroablation?\",\"answer\":\"No. Univariate analysis linked age ≥60 years with recurrence, but age was not an independent variable predicting the outcome.\"},{\"question\":\"How did pacemaker implantation relate to patient age after CNA?\",\"answer\":\"Six patients received pacemakers during follow-up, and all were older than 50 years; the need for permanent pacing increased with age starting from 55 years.\"}]","Older age is not an independent predictor of syncope recurrence following cardioneuroablation for reflex syncope | PDF",1790652595,23]