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SMH is evaluated through physical function and body composition tests, while cognitive status is assessed by a neuropsychological 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","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-20","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is skeletal muscle health considered an early biomarker for cognitive decline?","Question",{"text":63,"@type":64},"SMH deficiencies are strongly linked to Alzheimer’s progression and to concurrent declines in physical and cognitive function, suggesting SMH may indicate earlier cognitive deterioration.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How did the study assess skeletal muscle health in older adults?",{"text":68,"@type":64},"SMH was assessed using physical function tests including handgrip strength, sit-to-stand, gait assessments, a 6-minute walk, lower body power, and body composition via DXA.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the main results when comparing low cognition and high cognition groups?",{"text":72,"@type":64},"The LC group showed poorer overall performance and outcomes, including significant differences in measures such as habitual 10 m walk and handgrip, with additional significant differences among females.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},427918,1790815305,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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DISEASE  \nWITH LOWER COGNITIVE SCORES EXHIBIT POORER  \nSKELETAL MUSCLE HEALTH  \nRay Urbina1, Michelle Gray1, Anthony Campitelli2, Megan Jones1, Sally Paulson3, Joshua Gills4, and Jordan Glenn5, 1.  \nUniversity of Arkansas, Fayetteville, Arkansas, United States, 2.  \nCollege of Idaho, Caldwell, Idaho, United States, 3. University of Houston, Houston, Texas, United States, 4. New York University, New York, New York, United States, 5. SuppCo, Natick, Massachusetts, United States  \nAlzheimer’s disease (AD) is a major health concern, with early pathology often undetected due to costly assessments. Skeletal muscle health (SMH) deficiencies are strongly linked to AD progression and concurrent declines in physical and cognitive function, suggesting skeletal muscle health as an early biomarker for cognitive decline. This study examines SMH differences between low cognition (LC) and high cognition (HC) in older adults who are at risk for AD. SMH was assessed through physical function tests (PF)– handgrip strength (HG), 5-time sit-to-stand, gait assessments, 6-minute walk, and lower body power (TENDO)  \n– and body composition (DXA) . Cognitive health was evaluated using the Repeatable Battery for the Assessment of Neuropsychological Status. Individuals were grouped into low cognition (LC) or high cognition (HC) groups. Independent t-tests were used to analyze differences in means between LC and HC (α = .05) . LC consisted of 34 adults (M = 14, F = 20) and HChad 29 adults (M = 6, F = 23) . LC had lower performances and poorer outcomes in 16 out of 20 measurements, with significant differences in 10m habitual walk (p=.02) and Handgrip (p=.02) .  \nAmong females, seven measurements had significant differences between groups – weight (p=.04), lean mass (p=.03), chair stands (p=.02), 10m habitual (p=.02), 10m fast (p=.001), 10m DT habitual (p=.004), and peak power (p=.02) . Results show that the LC group demonstrated overall poorer performance and outcomes.  \nThese findings align with current literature reinforcing that LC individuals exhibit poorer skeletal muscle health when looking into function which may suggest an increased risk for cognitive decline.","cbCair244SSLKonr","https://ap.wps.com/l/cbCair244SSLKonr","pdf",651682,"English","# Study Background and Rationale\n## Cognitive Status Groups (LC vs HC)\n## Skeletal Muscle Health Assessment Methods\n## Statistical Comparison and Key Findings\n## Interpretation and Alignment With Literature","[{\"question\":\"Why is skeletal muscle health considered an early biomarker for cognitive decline?\",\"answer\":\"SMH deficiencies are strongly linked to Alzheimer’s progression and to concurrent declines in physical and cognitive function, suggesting SMH may indicate earlier cognitive deterioration.\"},{\"question\":\"How did the study assess skeletal muscle health in older adults?\",\"answer\":\"SMH was assessed using physical function tests including handgrip strength, sit-to-stand, gait assessments, a 6-minute walk, lower body power, and body composition via DXA.\"},{\"question\":\"What were the main results when comparing low cognition and high cognition groups?\",\"answer\":\"The LC group showed poorer overall performance and outcomes, including significant differences in measures such as habitual 10 m walk and handgrip, with additional significant differences among females.\"}]","OLDER ADULTS AT RISK FOR ALZHEIMER’S DISEASE WITH LOWER COGNITIVE SCORES EXHIBIT POORER SKELETAL MUSCLE HEALTH | PDF",1790645185]