[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-457533-105":59,"doc-detail-457533-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","old-dogs-new-tricks-multifaceted-functions-of-mavs-beyond-antivirus-activity-in-human-health-and-diseases","Old dogs-new tricks - Multifaceted functions of MAVS beyond antivirus activity in human health and diseases","","Mitochondrial Antiviral Signaling Protein (MAVS) serves as a central adaptor in innate immunity, traditionally linking to interferon (IFN) and NF-κB pathways to defend against viral infection. Accumulating evidence expands this role, showing MAVS as a signaling hub on the outer mitochondrial membrane that coordinates mitochondrial dynamics and cellular metabolism. MAVS influences apoptosis, NLRP3 inflammasome activation, metabolic reprogramming, and autophagy, and its dysregulation is tied to cancer, cardiovascular and autoimmune disorders, and neurological diseases. This review summarizes MAVS activation, downstream outputs, regulatory mechanisms, and therapeutic strategies targeting MAVS.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/old-dogs-new-tricks-multifaceted-functions-of-mavs-beyond-antivirus-activity-in-human-health-and-diseases/457533/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/old-dogs-new-tricks-multifaceted-functions-of-mavs-beyond-antivirus-activity-in-human-health-and-diseases/457533.png","ImageObject",300,407,{"name":92,"@type":93},"Mary Man","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-09","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is MAVS and where does it function in cells?","Question",{"text":113,"@type":114},"MAVS is a mitochondrial outer-membrane adaptor that acts as a key signaling hub connecting pathogen detection to inflammatory and stress responses.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does MAVS contribute to antiviral immunity?",{"text":118,"@type":114},"In the canonical pathway, RIG-I or MDA5 detects cytosolic dsRNA and activates MAVS, which recruits TBK1 to phosphorylate IRF3 and drive IFN production for viral clearance and immune homeostasis.",{"name":120,"@type":111,"acceptedAnswer":121},"What roles does MAVS play beyond antiviral signaling?",{"text":122,"@type":114},"MAVS regulates apoptosis, NLRP3 inflammasome activation, mitochondrial dynamics, metabolic reprogramming, and autophagy, affecting both physiological and pathological processes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},457533,1790980511,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":26,"preview_page_count":4},7421720224475,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Lu et al. Cell & Bioscience (2026) 16:1 [https://doi.org/10.1186/s13578-025-01512-9](https://doi.org/10.1186/s13578-025-01512-9)  \nCell & Bioscience  \nREVIEW Open Access  \nOld dogs-new tricks: multifaceted functions of MAVS beyond antivirus activity in human health and diseases  \nYating Lu 1, Yaxuan Qi 1, Qingqing Yinliang 1, Rui Zhu 1, Alexey Sarapultsev2,3, Shanshan Luo4, Jing Cui5* and Desheng Hu 1*  \nAbstract  \nMitochondrial Antiviral Signaling Protein (MAVS), a key adaptor in the innate immune system, has traditionally been recognized for its role in defending against viral infections through activation of the interferon (IFN) and NF-κB signaling pathways. Recent studies, however, have expanded this view, revealing that MAVS also functions at the intersection of innate immunity, mitochondrial dynamics, and cellular metabolism. Located on the outer mitochondrial membrane, MAVS serves as a critical signaling hub, linking pathogen detection to inflammatory and stress responses. Beyond its canonical antiviral roles, MAVS is now implicated in diverse physiological and pathological processes, including regulation of apoptosis, NLRP3 inflammasome activation, metabolic reprogramming, and autophagy. Its dysregulation contributes to the onset and progression of a range of diseases, such as cancer, cardiovascular and autoimmune disorders, and neurological conditions. This review provides a comprehensive overview of MAVS activation, downstream signaling outputs, and regulatory mechanisms. We also discuss the emerging evidence on MAVS-related diseases and therapeutic strategies targeting MAVS, emphasizing its broader significance in human health beyond antiviral immunity.  \nKeywords MAVS, Innate immunity, Mitochondria, Human disease, Therapeutics  \n*Correspondence: Jing Cui  \ncaroline1 [1122@163.com](1122@163.com)  \nDesheng Hu  \n[desheng.hu@hust.edu.cn](desheng.hu@hust.edu.cn)  \n1Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China  \n2Russian-Chinese Education and Research Center of System Pathology, South Ural State University, Chelyabinsk, Russia  \n3Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Science, 106 Pervomaiskaya Street, Yekaterinburg, Russia620049  \n4Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 5Health Management Center, Hubei Provincial Hospital of Integrated Chinese and Western Medicine, Wuhan 430015, China  \nIntroduction  \nThe innate immune system stands on the frontier against invading pathogens and cellular stress, providing immediate and nonspecific protection, and paving the way for adaptive immunity. Effective immune response requires sophisticated signaling pathway networks and relies on their precise coordination to achieve optimal protection results. At the beginning of the twenty-first century, the continuous discovery of RNA sensors Toll-like receptors (TLR)3/7/8 [1, 2], melanoma differentiation-associated gene 5 (MDA5) [3], and retinoic acid-inducible gene I (RIG-I) [4], which are sensitively activated in the presence of self-RNA or extraneous RNA, significantly broadened our understanding of innate immunity recognition. Myeloid differentiation factor-88 (MyD88) and TIR  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are inclu","cbCaibtggmsRjfyn","https://ap.wps.com/l/cbCaibtggmsRjfyn","pdf",2736065,24,"English","# Introduction\n## MAVS in RIG-I/MDA5 signaling\n## Expanded roles beyond antiviral immunity\n# MAVS as a hub for immune-metabolic regulation\n## Regulation of cell death and inflammasome activation\n## Mitochondrial dynamics, metabolism, and autophagy\n# MAVS in human diseases and therapeutic strategies","[{\"question\":\"What is MAVS and where does it function in cells?\",\"answer\":\"MAVS is a mitochondrial outer-membrane adaptor that acts as a key signaling hub connecting pathogen detection to inflammatory and stress responses.\"},{\"question\":\"How does MAVS contribute to antiviral immunity?\",\"answer\":\"In the canonical pathway, RIG-I or MDA5 detects cytosolic dsRNA and activates MAVS, which recruits TBK1 to phosphorylate IRF3 and drive IFN production for viral clearance and immune homeostasis.\"},{\"question\":\"What roles does MAVS play beyond antiviral signaling?\",\"answer\":\"MAVS regulates apoptosis, NLRP3 inflammasome activation, mitochondrial dynamics, metabolic reprogramming, and autophagy, affecting both physiological and pathological processes.\"}]","Old dogs-new tricks - Multifaceted functions of MAVS beyond antivirus activity in human health and diseases | PDF",1790749639]