[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31465":3,"doc-seo-31465":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31465,1099513958607,"Jiven","https://ap-avatar.wpscdn.com/avatar/100002390cf8733938c?x-image-process=image/resize,m_fixed,w_180,h_180&k=1778829742770036399",7,"Healthcare","Obesity Medicine Journal Article on Energy Homeostasis and Leptin Signaling","Obesity is a complex, multifactorial disease driven by chronic disruption of energy intake and energy expenditure, creating major global health and socioeconomic burdens through comorbidities such as type 2 diabetes and cardiovascular disease. Body-weight regulation depends on a neuroendocrine network integrating central and peripheral signals, with the hypothalamus as a key hub that coordinates appetite, glucose metabolism, and energy expenditure. The document also highlights adipose tissue as an endocrine and inflammatory source, the gut-brain axis, cellular oxidative pathways, and environmental/behavioral influences, emphasizing the challenge of long-term obesity treatment. It introduces leptin’s role in long-term energy balance and appetite regulation, including leptin signaling mechanisms and leptin resistance.","cbCaidiqCxbD1n68","https://ap.wps.com/l/cbCaidiqCxbD1n68","pdf",2681528,1,18,"English","en","# Introduction\n# Leptin in energy balance and appetite regulation","[{\"question\":\"What main mechanism drives obesity according to the document?\",\"answer\":\"Obesity results from a chronic imbalance between energy intake and energy expenditure, leading to abnormal or excessive fat accumulation.\"},{\"question\":\"How does the neuroendocrine system regulate body weight and energy balance?\",\"answer\":\"A coordinated neuroendocrine system integrates central and peripheral signals to maintain caloric intake, energy expenditure, and fat storage, with the hypothalamus playing a central role.\"},{\"question\":\"Why are effective long-term obesity treatments difficult?\",\"answer\":\"The body’s energy homeostasis system defends against sustained weight loss by adjusting appetite and energy expenditure to restore lost weight.\"}]",1779570025,45,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"obesity-medicine-journal-article-on-energy-homeostasis-and-leptin-signaling","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/healthcare/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/obesity-medicine-journal-article-on-energy-homeostasis-and-leptin-signaling/31465/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-23",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What main mechanism drives obesity according to the document?","Question",{"text":73,"@type":74},"Obesity results from a chronic imbalance between energy intake and energy expenditure, leading to abnormal or excessive fat accumulation.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How does the neuroendocrine system regulate body weight and energy balance?",{"text":78,"@type":74},"A coordinated neuroendocrine system integrates central and peripheral signals to maintain caloric intake, energy expenditure, and fat storage, with the hypothalamus playing a central role.",{"name":80,"@type":71,"acceptedAnswer":81},"Why are effective long-term obesity treatments difficult?",{"text":82,"@type":74},"The body’s energy homeostasis system defends against sustained weight loss by adjusting appetite and energy expenditure to restore lost weight.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]