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Obesity is associated with elevated leptin (hyperleptinemia), and leptin is a recognized driver of breast cancer metastasis. Yet the impact of hyperleptinemia on tumor angiogenesis remains less defined. This review analyzes how leptin regulates angiogenesis in breast cancer, focusing on obese patients and the tumor microenvironment.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/obesity-and-leptin-in-breast-cancer-angiogenesis-review/338336/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/obesity-and-leptin-in-breast-cancer-angiogenesis-review/338336.png","ImageObject",300,407,{"name":92,"@type":93},"Sage","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How is obesity related to breast cancer prognosis?","Question",{"text":112,"@type":113},"Patients classified as obese (BMI > 30) at diagnosis have poorer prognoses than patients with lean BMI, indicating an unfavorable clinical impact of obesity on outcomes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role does leptin play in breast cancer?",{"text":117,"@type":113},"Leptin is described as a well-established driver of metastasis in breast cancer, and obesity is linked to hyperleptinemia that may influence disease processes.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is angiogenesis important in breast cancer?",{"text":121,"@type":113},"Angiogenesis supports tumor growth beyond very small sizes by enabling oxygen and nutrient delivery, and it also provides a pathway for metastasis through blood or lymphatic circulation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},338336,1790085712,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687197207057,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","TYPE Review  \nPUBLISHED 08 October 2024 DOI 10.3389/fendo.2024.1465727  \nOPEN ACCESS  \nEDITED BY  \nNatalia Simona Pellegata, University of Pavia, Italy  \nREVIEWED BY  \nVincenza Cifarelli,  \nSaint Louis University, United States Arunasalam Dharmarajan, Sri Ramachandra Institute of Higher Education and Research, India  \n*CORRESPONDENCE  \nMatthew E. Burow  \n [mburow@tulane.edu](mburow@tulane.edu)[ ](mburow@tulane.edu)Jennifer S. Fang  \n[jfang5@tulane.edu](jfang5@tulane.edu)  \nRECEIVED 16 July 2024  \nACCEPTED 04 September 2024  \nPUBLISHED 08 October 2024  \nCITATION  \nLagarde CB, Thapa K, Cullen NM, Hawes ML, Salim K, Benz MC, Dietrich SR, Burow BE, Bunnell BA, Martin EC, Collins-Burow BM, Lynch RM, Hoang VT, Burow ME and Fang JS  \n(2024) Obesity and leptin in breast cancer angiogenesis.  \nFront. Endocrinol. 15:1465727 .  \ndoi: 10.3389/fendo.2024.1465727  \nCOPYRIGHT  \n© 2024 Lagarde, Thapa, Cullen, Hawes, Salim, Benz, Dietrich, Burow, Bunnell, Martin, Collins-Burow, Lynch, Hoang, Burow and Fang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nObesity and leptin in breast cancer angiogenesis  \nCourtney B. Lagarde 1,2, Kapil Thapa3, Nicole M. Cullen 1,2, Mackenzie L. Hawes 1,2, Khudeja Salim 1,2, Megan C. Benz 1,2, Sophie R. Dietrich 1,2,4, Brandon E. Burow 3, Bruce A. Bunnell 5, Elizabeth C. Martin 1,2, Bridgette M. Collins-Burow 1,2, Ronald M. Lynch 6, Van T. Hoang 1,2, Matthew E. Burow 1,2,7,8* and Jennifer S. Fang 3,9*  \n1 Department of Medicine, Section of Hematology and Oncology, Tulane University School of Medicine, New Orleans, LA, United States, 2Tulane University Cancer Center, New Orleans,  \nLA, United States, 3 Department of Cell and Molecular Biology, Tulane University School of Science and Engineering, New Orleans, LA, United States, 4 United States Department of Agriculture Southern Regional Research Center, New Orleans, LA, United States, 5 Department of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, TX, United States, 6 Department of Physiology, College of Medicine, University of Arizona, Tucson, AZ, United States, 7 Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA, United States, 8 Department of Surgery, Tulane University School of Medicine, New Orleans, LA, United States, 9 Department of Physiology, Tulane University School of Medicine, New Orleans, LA, United States  \nAt the time of breast cancer diagnosis, most patients meet the diagnostic criteria to be classified as obese or overweight. This can significantly impact patient outcome: breast cancer patients with obesity (body mass index > 30) have a poorer prognosis compared to patients with a lean BMI. Obesity is associated with hyperleptinemia, and leptin is a well-established driver of metastasis in breast cancer. However, the effect of hyperleptinemia on angiogenesis in breast cancer is less well-known. Angiogenesis is an important process in breast cancer because it is essential for tumor growth beyond 1mm3 in size as well as cancer cell circulation and metastasis. This review investigates the role of leptin in regulating angiogenesis, specifically within the context of breast cancer and the associated tumor microenvironment in obese patients.  \nKEYWORDS  \nleptin, angiogenesis, breast cancer, obesity, hyperleptinemia, tumor microenvironment  \nIntroduction  \nAll cells, including cancer cells, depend on the vasculature for oxygen, nutrient access and waste removal to support their basic metabolic functions. This is particularly true for fast-growing solid tumors, where the densely ","cbCaidsGsPK0dfOG","https://ap.wps.com/l/cbCaidsGsPK0dfOG","pdf",3381428,14,"English","# Introduction\n## Tumor dependence on vasculature and angiogenesis\n## Obesity, inflammation, and cancer outcomes\n## Links between obesity and breast cancer risk","[{\"question\":\"How is obesity related to breast cancer prognosis?\",\"answer\":\"Patients classified as obese (BMI \\u003e 30) at diagnosis have poorer prognoses than patients with lean BMI, indicating an unfavorable clinical impact of obesity on outcomes.\"},{\"question\":\"What role does leptin play in breast cancer?\",\"answer\":\"Leptin is described as a well-established driver of metastasis in breast cancer, and obesity is linked to hyperleptinemia that may influence disease processes.\"},{\"question\":\"Why is angiogenesis important in breast cancer?\",\"answer\":\"Angiogenesis supports tumor growth beyond very small sizes by enabling oxygen and nutrient delivery, and it also provides a pathway for metastasis through blood or lymphatic circulation.\"}]","Obesity and leptin in breast cancer angiogenesis - Review | PDF",1790023118,35]