[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-448168-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-448168-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","o-glcnacylation-levels-predict-radiotherapy-outcome-in-non-small-cell-lung-cancer","O-GlcNAcylation levels predict radiotherapy outcome in non-small cell lung cancer","","Limited evidence addresses how protein glycosylation, especially O-GlcNAcylation, relates to radiotherapy effectiveness in non-small cell lung cancer. A retrospective cohort of 216 patients undergoing radiotherapy and PET-CT assessed pretreatment tumor O-GlcNAc expression by immunohistochemistry, along with blood glucose and primary tumor glucose uptake (SUVmax). Low O-GlcNAc independently predicted poorer radiotherapy response and worse progression-free and overall survival, while glucose and SUVmax showed no association with response. High O-GlcNAc indicated more favorable outcomes.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/o-glcnacylation-levels-predict-radiotherapy-outcome-in-non-small-cell-lung-cancer/448168/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/o-glcnacylation-levels-predict-radiotherapy-outcome-in-non-small-cell-lung-cancer/448168.png","ImageObject",300,407,{"name":42,"@type":43},"Oliver","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What study assessed O-GlcNAcylation levels in non-small cell lung cancer?","Question",{"text":63,"@type":64},"The study evaluated how pretreatment O-GlcNAc expression in primary tumors relates to radiotherapy response and survival in 216 NSCLC patients treated with radiotherapy and PET-CT.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was O-GlcNAc expression measured?",{"text":68,"@type":64},"Pretreatment primary tumor specimens were assessed by immunohistochemistry, and patients were categorized into high- and low-expression groups.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the main findings about radiotherapy response and survival?",{"text":72,"@type":64},"Low O-GlcNAc expression was independently associated with poor radiotherapy response and predicted shorter progression-free survival and overall survival.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},448168,1790781713,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","O-GlcNAcylation levels predict radiotherapy outcome in non-small cell lung cancer  \nXiaoliang Wang1,2, Yujiao Ma1,2, Ying Dong1,2, Yanling Wang3, Jupeng Yuan2, Jinming Yu1,2, Dawei Chen1,2  \n1Cheeloo College of Medicine, Shandong University Cancer Center, Jinan, China; 2Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China; 3Department of Information Engineering, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China  \nContributions: (I) Conception and design: J Yu, D Chen, J Yuan, X Wang; (II) Administrative support: J Yu, D Chen, J Yuan; (III) Provision of study materials or patients: All authors; (IV) Collection and assembly of data: Y Ma, Y Wang, X Wang, Y Dong; (V) Data analysis and interpretation: Y Wang, X Wang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \nCorrespondence to: Dawei Chen, MD, PhD; Jinming Yu, MD, PhD. Cheeloo College of Medicine, Shandong University Cancer Center, No.  \n440, Jiyan Road, Jinan 250001, China; Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. Email: [dave0505@yeah.net](dave0505@yeah.net); [sdyujinming@163.com](sdyujinming@163.com).  \nBackground: Limited evidence exists on the role of protein glycosylation, particularly O-GlcNAcylation (O-GlcNAc), in predicting radiotherapy (RT) response in non-small cell lung cancer (NSCLC) . This study aimed to investigate O-GlcNAc expression, glucose metabolism indicators, and their associations with RT  \nresponse and prognosis in NSCLC.  \nMethods: We conducted a retrospective cohort study of 216 NSCLC patients who underwent RT and positron emission tomography-computed tomography (PET-CT) imaging. O-GlcNAc expression in pretreatment primary tumor specimens was evaluated by immunohistochemistry (IHC), and patients were categorized into high-and low-expression groups. All patients were matched for age, sex, diagnosis, and pathological stage. Clinical features were reviewed, and multivariable logistic regression was applied to analyze associations between O-GlcNAc levels and clinical parameters. The conditional logistic regression was used to calculate odds ratios (ORs) with 95% confidence intervals (CIs) . Kaplan-Meier analysis was performed to evaluate the prognostic impact of O-GlcNAc expression. Pretreatment blood glucose levels and primary tumor glucose uptake [maximum standardized uptake value (SUVmax)] from PET-CT were also assessed, and correlation analyses were conducted to determine their relationships with RT response and  \nsurvival outcomes.  \nResults: Low O-GlcNAc expression was independently associated with poor RT response (P=0.005; OR =2.47; 95% CI: 1.32–4.64) and significantly predicted shorter progression-free survival (PFS; log-rank P=0.049) and overall survival (OS; log-rank P=0.008) . In contrast, blood glucose levels (P=0.59) and primary tumor SUVmax (P=0.38) showed no association with RT response, and neither blood glucose nor SUVmax  \ncorrelated with PFS; however, high SUVmax was predictive of shorter OS (log-rank P=0.03) .  \nConclusions: High O-GlcNAc expression was a predictor of favorable RT response and improved PFS  \nand OS in NSCLC patients.  \nKeywords: Non-small cell lung cancer (NSCLC); O-GlcNAcylation (O-GlcNAc); radiotherapy (RT); maximum  \nstandardized uptake value (SUVmax); blood glucose  \nSubmitted Sep 01, 2025. Accepted for publication Oct 29, 2025. Published online Dec 29, 2025.  \ndoi: 10.21037/tlcr-2025-998  \nView this article at: [https://dx.doi.org/10.21037/tlcr-2025-998](https://dx.doi.org/10.21037/tlcr-2025-998)  \n© AME Publishing Company. Transl Lung Cancer Res","cbCaimQHKKJLAmdA","https://ap.wps.com/l/cbCaimQHKKJLAmdA","pdf",3132754,14,"English","# Introduction\n# Methods\n# Results\n# Conclusions\n# Keywords","[{\"question\":\"What study assessed O-GlcNAcylation levels in non-small cell lung cancer?\",\"answer\":\"The study evaluated how pretreatment O-GlcNAc expression in primary tumors relates to radiotherapy response and survival in 216 NSCLC patients treated with radiotherapy and PET-CT.\"},{\"question\":\"How was O-GlcNAc expression measured?\",\"answer\":\"Pretreatment primary tumor specimens were assessed by immunohistochemistry, and patients were categorized into high- and low-expression groups.\"},{\"question\":\"What were the main findings about radiotherapy response and survival?\",\"answer\":\"Low O-GlcNAc expression was independently associated with poor radiotherapy response and predicted shorter progression-free survival and overall survival.\"}]","O-GlcNAcylation levels predict radiotherapy outcome in non-small cell lung cancer | PDF",1790725814,35]