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Nutritional status was assessed with Patient-Generated Subjective Global Assessment (PG-SGA), nutritional blood biomarkers, food intake frequencies, malnutrition level ratings, and triage recommendations, with multivariate regression to model demographic and clinical predictors. Results showed many patients had inadequate intake after diagnosis and most required nutritional intervention, with late-stage disease associated with worse nutritional status and elevated risk 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was the study objective regarding cervical cancer patients in Tanzania?","Question",{"text":63,"@type":64},"To evaluate the nutritional status of cervical cancer patients treated at ORCI in Tanzania and determine how nutritional status relates to patient outcomes.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was nutritional status measured in the study?",{"text":68,"@type":64},"Nutritional status was assessed using PG-SGA scores, nutritional blood biomarkers, food intake frequencies, a categorical malnutrition level rating, and a triage recommendation.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the study find about malnutrition in early vs late-stage patients?",{"text":72,"@type":64},"Moderate or severe malnutrition was more common in late-stage disease: about half of early-stage patients versus a much larger proportion of late-stage patients showed moderate or severe 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New York School of Public Health  \nOcean Road Cancer Institute  \nTanzania Food and Nutrition Center  \nCity University of New York School of Medicine  \nTanzania Food and Nutrition Center  \nORCI, Tanzania, Cervical Cancer, HPV, Nutrition, PG-SGA  December 18th, 2025  \n [https://doi.org/10.21203/rs.3.rs-7780798/v1](https://doi.org/10.21203/rs.3.rs-7780798/v1)  \n 􀁱 􀅏 This work is licensed under a Creative Commons Attribution 4.0 International License.  \nRead Full License  \n No competing interests reported.  \nCervical cancer is the most common cancer affecting Tanzanian women. The nutritional status of patients with cervical cancer may in¬ uence cervical cancer outcomes. However, no information is available regarding the nutritional status of the Tanzanian cervical cancer patients. Therefore, we evaluated the nutritional status of patients with cervical cancer treated at the Ocean Road Cancer Institute (ORCI) in Tanzania.  \nWe conducted a cross-sectional study of 184 newly diagnosed patients with cervical cancer seen at the oncology clinic of ORCI from April to September 2023. Assessment of the nutritional status was based on the Patient-Generated Subjective Global Assessment (PG-SGA) scores. The overall nutritional status was evaluated using nutritional blood biomarkers, food intake frequencies, a categorical rating indicating the level of malnourishment, and a triage recommendation. Multivariate regression analysis was performed to predict nutritional status based on demographic and clinical variables.  \nAmong the total patient population, 39. 1% reported consuming less food after diagnosis, especially the intake of cereals, dark leafy green vegetables, orange vegetables, other vegetables, as well as oils, and fats. The majority (84 .8%) of patients required nutritional intervention based on their nutritional status. Almost half (48%) of patients with early-stage cervical cancer (stages I, II) and 78% of patients with latestage cervical cancer (Stage III, IV), showed moderate or severe malnutrition. The risk of malnutrition was signi«cantly higher in patients with late-stage vs early-stage cancer (8 .0 ± 1.4 vs. 5.9 ± 0 .8; p = 0.0173) . Similarly, patients with late-stages had higher mean levels of white blood cells (late vs. early:  \n9.0 ± 1.1 vs. 7.6 ± 0 . 6; p = 0 .0216), platelets (396 .3 ± 39.4 vs. 347.5 ± 23 .9; p = 0 .0399), the ratio of platelet to neutrophil count (101 .7 ± 13.8 vs. 82.3 ± 1 . 6; p = 0 .0294), and the liver function test, aspartate aminotransferase (AST) enzyme (31 .9 ± 5.9 vs. 24.5 ± 2 .0; p = 0 .0201) . Late-stage patients were predicted to have a worse nutritional status (late vs. early: mean = 7.8 vs. 6.0, p = 0 .04), after adjusting for sociodemographic covariates. Further adjustments by smoking, alcohol use and physical activity did not affect the model.  \nNutritional status of patients with late-stage cervical cancer in Tanzania should be prioritized during the management of patients with cervical cancer, especially for late-stage patients. This study may have  \ntranslation to other low-income countries facing challenges in cancer management, poverty, and challenges in food security.  \nCervical cancer is a signi«cant and most common cancer affecting women in Sub-Saharan Africa, including Tanzania [1–3] . Cancer mortality among patients with cervical cancer in Tanzania is high (agestandardized incidence rate = 42 .2/100,000), and late-stage presentation, as well as short survival among Tanzanian patients with cervical cancer, call for interventions for improving patient management [4] .  \nTanzania has faced a high cervical cancer incidence (age-standardized mortality rate = 64 .8/100,000) and malnourishment [2, 4–6] . Cervical cancer is caused by the human papillomavirus (HPV) [7], and past research showed that the nutritional status of patients may modify cervical cancer outcomes and response to trea","cbCaieY14zbjpZ71","https://ap.wps.com/l/cbCaieY14zbjpZ71","pdf",1082604,"English","# Study rationale\n# Study design and participants\n# Nutritional assessment methods\n# Key findings and predictors\n# Implications for clinical management","[{\"question\":\"What was the study objective regarding cervical cancer patients in Tanzania?\",\"answer\":\"To evaluate the nutritional status of cervical cancer patients treated at ORCI in Tanzania and determine how nutritional status relates to patient outcomes.\"},{\"question\":\"How was nutritional status measured in the study?\",\"answer\":\"Nutritional status was assessed using PG-SGA scores, nutritional blood biomarkers, food intake frequencies, a categorical malnutrition level rating, and a triage recommendation.\"},{\"question\":\"What did the study find about malnutrition in early vs late-stage patients?\",\"answer\":\"Moderate or severe malnutrition was more common in late-stage disease: about half of early-stage patients versus a much larger proportion of late-stage patients showed moderate or severe malnutrition.\"}]","Nutritional Status of Patients Diagnosed with Cervical Cancer in Tanzania - Research findings | PDF",1790741055]