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Using Clinical PhenoAge (PA) to better capture biological aging processes than chronological age, the study calculated biological age advancement (BAA) in UK Biobank (N=103,344) and NHANES 2015–2018 (N=4,264). Higher nutrition density via NRF9.3 (adequate intake of 12 nutrients) corresponded to lower BAA, with BMI partially mediating the association. Fiber and magnesium were linked to reduced BAA, while added sugars predicted higher BAA.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nutritional-density-and-its-impact-on-biological-age-insights-from-large-cohort-studies/426384/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nutritional-density-and-its-impact-on-biological-age-insights-from-large-cohort-studies/426384.png","ImageObject",300,407,{"name":92,"@type":93},"Aran","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological aging measure did the study use, and why?","Question",{"text":112,"@type":113},"The study used Clinical PhenoAge (PA) as an indicator of health status reflecting biological aging processes more closely than chronological age.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was nutrition density quantified in this research?",{"text":117,"@type":113},"Nutrition density was measured using the NRF9.3 score, which evaluates adequate intakes of 12 nutrients, alongside analyses of specific nutrient intakes.",{"name":119,"@type":110,"acceptedAnswer":120},"Which nutrients were associated with lower or higher biological age advancement?",{"text":121,"@type":113},"Fiber and magnesium were associated with lower BAA, whereas added sugars were associated with higher BAA in both cohorts.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426384,1790851805,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},137455076865,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Innovation in Aging, 2025, Vol. 9, No. S2 1189  \nAbstract citation ID: igaf122.3982  \nNUTRITIONAL DENSITY AND ITS IMPACT ON  \nBIOLOGICAL AGE: INSIGHTS FROM LARGE  \nCOHORT STUDIES  \nEleonora Porcu, Charlotte Debras, Shu Wang, Li-Tang Tsai, Alberto Conde Freniche, Philipp Gut, and Sébastien Herzig, Nestle Institute of Health Science, Lausanne, Vaud,  \nSwitzerland  \nRelationships between nutrition and aging represent a critical area of research, as dietary choices can influence health and disease risk. In this study, we used Clinical PhenoAge (PA) as an indicator of health status reflecting biological processes of aging better than chronological age. We calculated biological age advancement (BAA) in two populations (UKBiobank, N = 103,344 and NHANES 2015-2018, N = 4,264) as the difference between PA and chronological age and explored the association with specific diet quality scores. To this end we used nutrition density (measured using NRF9.3 score, a method  \n1190 Innovation in Aging, 2025, Vol. 9, No. S2  \nevaluating adequate intakes of 12 nutrients) as well as individual nutrient intake. After adjusting for relevant anthropometric, sociodemographic and health-related covariates, the linear regression analyses revealed that a 50-point increase of NRF9.3 is associated with lower BAA in UKBiobank (β=-0.093[95% CI:  \n-0.103,-0.083], P \u003C 0.001) and in NHANES (β=-0.152[-0.192,- 0.112], P\u003C 0.001). Given that BMI is often influenced by dietary choices and could be associated with PA, we aimed to investigate whether the association between NRF9 .3 and BAA could be mediated by BMI. Mediation analysis indicated that a modest part of the association was mediated by BMI (19%[16%-22%] in UKBiobank, and 12%[6%-19%] in NHANES, P \u003C 0 .001) .  \nFurthermore, we identified specific nutrients associated with lower BAA, including fiber (β_UKBiobank=-0.11[-0.13,-0.09],β_NHANES=-0.44 [-0.59,-0.30], P\u003C 0.001) and magnesium (β_UKBiobank=-0.11[-0.13,-0.09], β_NHANES=-0.46[-0.60,- 0.31],P\u003C 0.001) . Conversely, nutrients associated with higher BAA included added sugars (β_UKBiobank=0.15[0.13,0.17],β_NHANES=0.35[0.21,0.50], P\u003C 0.001) . Overall, these findings suggest the relevant role of diet in biological aging, highlighting the potential for targeted nutritional interventions promoting healthier aging, ultimately leading to healthy longevity.","cbCaimBOryXwNux2","https://ap.wps.com/l/cbCaimBOryXwNux2","pdf",2052128,"English","# Abstract\n## Nutrition density and biological age\n## Mediation by BMI\n## Nutrients linked to BAA","[{\"question\":\"What biological aging measure did the study use, and why?\",\"answer\":\"The study used Clinical PhenoAge (PA) as an indicator of health status reflecting biological aging processes more closely than chronological age.\"},{\"question\":\"How was nutrition density quantified in this research?\",\"answer\":\"Nutrition density was measured using the NRF9.3 score, which evaluates adequate intakes of 12 nutrients, alongside analyses of specific nutrient intakes.\"},{\"question\":\"Which nutrients were associated with lower or higher biological age advancement?\",\"answer\":\"Fiber and magnesium were associated with lower BAA, whereas added sugars were associated with higher BAA in both cohorts.\"}]","NUTRITIONAL DENSITY AND ITS IMPACT ON BIOLOGICAL AGE: INSIGHTS FROM LARGE COHORT STUDIES | PDF",1790640382]