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Peripheral nerve damage can stabilize or improve with timely diagnosis, appropriate interventions, and symptomatic treatment to improve quality of life.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/nutritional-and-toxic-neuropathies-nutritional-and-toxic-neuropathies/542121/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/nutritional-and-toxic-neuropathies-nutritional-and-toxic-neuropathies/542121.png","ImageObject",300,407,{"name":42,"@type":43},"Grenda","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-22","2026-10-10",true,{"@type":52,"interactionType":53,"userInteractionCount":33},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What are the main causes of nutritional and toxic neuropathies covered in the article?","Question",{"text":62,"@type":63},"Nutritional deficiencies, certain toxins, and medications are highlighted as common causes of nerve injury. It also discusses neuropathy associated with immune checkpoint inhibitors and chemotherapy.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"Why is early recognition of post-bariatric vitamin deficiency neuropathy important?",{"text":67,"@type":63},"The article stresses that vitamin deficiency–related neuropathy after bariatric surgery must be recognized early. Timely diagnosis and interventions support stabilization or potential improvement.",{"name":69,"@type":60,"acceptedAnswer":70},"How long does peripheral nerve recovery typically take?",{"text":71,"@type":63},"Peripheral nerves generally require about 12 to 18 months to recover, depending on the degree of injury, which helps guide counseling on prognosis.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},542121,1792170826,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":33,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},7971474921005,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Downloaded from [https://continuum.aan.com by Reichman University on 5 October 2026](https://continuum.aan.com by Reichman University on 5 October 2026)  \nREVIEW ARTICLE  \nCONTINUUM AUDIO INTERVIEW AVAI LABLEON LINE  \nCONTINUUM ALOUD RECORDING AVAI LAB LEON LINE  \nC ITE AS :  \nCONTINUUM (MIN NEA P M INN) 2026;32(5, PERIPHERAL NERVE AND MOTOR NEURON DISORDERS):1340–1364.  \nAddress correspondence to Dr Karissa L. Gable, Duke University Medical Center 3909, Durham, NC 27710, [karissa.gable@duke.edu](karissa.gable@duke.edu).  \nRELATIONSHIP DISCLOSURE: Dr Gable has received personal compensation in the range of $500 to $4999 for serving as a consultant for AstraZeneca, Guidepoint Global, LLC, and Sanofi and on a scientific advisory or data safety monitoring board forargenx; in the range of $5000 to $9999 for serving as a consultant for Annexon, Inc, argenx, CSL Limited, Grifols, S.A. , and Immunovant, Inc, and on a scientific advisory or data safety monitoring board for Sanofi; and in the range of $10, 000 to $49,999 for serving as a consultant for CVS Caremark and Takeda Pharmaceutical Company Limited.  \nUNLABELED USE OF PRODUCTS/ INVESTIGATIONAL USE DISCLOSURE:  \nDr Gable reports no disclosure.  \nAll cases in this article are hypothetical or composite.  \n© 2026 American Academy of Neurology.  \n1340  \nNutritional and Toxic Neuropathies  \nBy Karissa L. Gable, MD, FAAN  \nABSTRACT  \nOBJECTIVE: This article reviews the etiologies, clinical presentations, and management of nutritional and toxic neuropathies.  \nLATEST DEVELOPMENTS: Nutritional deficiencies and certain toxins and medications are common causes of nerve injury. The increase in rates of bariatric surgery and immunotherapy to treat malignancies has led to a need for increased awareness of associated neuropathies. Vitamin deficiency–related neuropathy due to inadequate supplementation after bariatric surgery is important to recognize early. Checkpoint inhibitor neuropathy can occur as a side effect of this medication class and can require urgent evaluation and treatment.  \nESSENTIAL POINTS: Peripheral nerve damage related to toxins or nutritional deficiencies can occur and can be stabilized or, in some cases, improved once diagnosed. Early detection and appropriate interventions, along with symptomatic treatment, are important for achieving an optimal response and improving quality of life.  \nINTRODUCTION  \nN  \neuropathy has long been associated with certain types of vitamin deficiencies and toxic exposures. This article reviews the etiology of those circumstances, how to recognize the symptoms, and how to treat and manage the symptoms once the cause is discovered. Specifically, this article addresses the neurologic consequences of  \ndeficiencies in the B-group of vitamins, vitamin E, and copper. With respect to toxic neuropathies, this article also discusses how immune checkpoint inhibitors (ICIs) and chemotherapy can contribute to neuropathy. Other medications and toxins discussed include immunosuppressants, cardiovascular medications, antiseizure medications, heavy metals, and nitrous oxide.  \nBecause the ability to promote nerve regeneration is still being investigated, the current approach is to replace a nutritional deficiency or stop a toxic medication or exposure and allow time for the nerve to heal.1 Research reports that it takes approximately 12 to 18 months for peripheral nerves to recover, depending on the degree of injury.2 This range is helpful when counseling patients about expectations and prognosis for recovery.  \nOCTOBER 2026  \nCopyright © 2026 American Academy of Neurology. Unauthorized reproduction of this article is prohibited.  \nDownloaded from [https://continuum.aan.com by Reichman University on 5 October 2026](https://continuum.aan.com by Reichman University on 5 October 2026)  \nNUTRITIONAL NEUROPATHIES  \nThis section covers common nutrition-related neuropathies associated with either deficiency or toxicity, as well as neurologic manifestations and treatment. The","cbCaid03gaA2bYaT","https://ap.wps.com/l/cbCaid03gaA2bYaT","pdf",762987,25,"English","# Abstract\n# Introduction\n# Nutritional Neuropathies\n## Summary table of nutritional intake, testing, and treatment (TABLE 3-1)","[{\"question\":\"What are the main causes of nutritional and toxic neuropathies covered in the article?\",\"answer\":\"Nutritional deficiencies, certain toxins, and medications are highlighted as common causes of nerve injury. It also discusses neuropathy associated with immune checkpoint inhibitors and chemotherapy.\"},{\"question\":\"Why is early recognition of post-bariatric vitamin deficiency neuropathy important?\",\"answer\":\"The article stresses that vitamin deficiency–related neuropathy after bariatric surgery must be recognized early. Timely diagnosis and interventions support stabilization or potential improvement.\"},{\"question\":\"How long does peripheral nerve recovery typically take?\",\"answer\":\"Peripheral nerves generally require about 12 to 18 months to recover, depending on the degree of injury, which helps guide counseling on prognosis.\"}]","Nutritional and Toxic Neuropathies - Nutritional and Toxic Neuropathies | PDF",1791670914,63]