[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-443751-105":59,"doc-detail-443751-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","nutraceuticals-for-oral-health-scientific-rationale-and-clinical-potential-in-endodontics","Nutraceuticals for oral health - scientific rationale and clinical potential in endodontics","","Letter to the editor addressing the scientific link between nutrition and disease modulation and introducing nutraceuticals as complementary agents rather than replacements for standard therapies. It reviews evidence that bioactive compounds can exert anti-inflammatory, antioxidant, and immunomodulatory effects across medical and dental specialties, while highlighting that endodontics remains underexplored. The discussion focuses on apical periodontitis, host immune and nutritional status, systemic spillover risks, and the need for clinical trials on adjunctive nutraceutical supplementation to support periapical healing and control inflammation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nutraceuticals-for-oral-health-scientific-rationale-and-clinical-potential-in-endodontics/443751/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nutraceuticals-for-oral-health-scientific-rationale-and-clinical-potential-in-endodontics/443751.png","ImageObject",300,407,{"name":92,"@type":93},"Damian","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What distinguishes nutraceuticals from conventional pharmaceuticals in this letter?","Question",{"text":112,"@type":113},"Nutraceuticals are presented as complementary agents for prevention and treatment rather than replacements for standard therapies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why is apical periodontitis discussed as more than a local condition?",{"text":117,"@type":113},"The letter explains that immune-inflammatory reactions in periapical lesions can have systemic spillover effects in predisposed individuals.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence gap exists regarding endodontics?",{"text":121,"@type":113},"The letter states that only limited experimental evidence and a lack of clinical trials evaluate whether adjunctive nutraceuticals support periapical healing or control local and systemic inflammation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},443751,1791132200,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":39,"preview_page_count":4},137451208677,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","LETTER TO THE EDITOR  \nNutraceuticals for oral health: scientific rationale and clinical potential in endodontics  \nRomulo de Oliveria Sales-Juniora, Renan Dal-Fabbrob, Luciano Tavares Ângelo Cintraa and João Eduardo Gomes-Filhoa  \na Department of Preventive and Restorative Dentistry. São Paulo State University (Unesp), School of Dentistry, Araçatuba, São Paulo, Brasil; bDepartment of Cariology, Restorative Sciences, and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA  \nDear Editor,  \nThe scientific understanding of the link between nutrition and disease modulation has grown significantly since the early discoveries of micronutrient deficiencies established the vital role of diet in health and disease management [1]. The concept of nutraceuticals (bioactive substances derived from foods that provide health benefits beyond basic nutrition) has gained prominence in both research and clinical practice [2] . Unlike conventional pharmaceuticals, nutraceuticals are not intended to replace standard therapies; rather, they are increasingly recognized for their potential as complementary agents in disease prevention and treatment [1] . Studies have begun to elucidate the mechanisms by which various nutraceutical compounds exert anti-inflammatory, antioxidant, and immunomodulatory effects, with promising results in chronic, multifactorial conditions such as metabolic syndrome, cardiovascular disease, and certain inflammatory disorders [1, 2] . Several medical specialties have already integrated nutraceuticals into their therapeutic protocols. In dentistry, they have been explored across several subfields for their potential to modulate inflammatory pathways, oxidative stress, and the oral microbiome [3, 4] . The strongest evidence to date comes from periodontology, where bioactive compounds show promise for controlling inflammation and supporting tissue repair [3, 4] . Incariology, nutraceuticals may help prevent dental caries by inhibiting cariogenic pathogens and maintaining microbial balance, while in orthodontics, they may reduce plaque accumulation and gingival inflammation [4] . In implantology, probiotics, polyphenols, and vitamins have been linked to improved osseointegration [4] . In oral medicine, they may help preserve mucosal integrity and prevent common oral diseases [4] . However, despite these advances, the role of nutraceuticalsin endodontics remains largely unexplored. One emerging concept is that nutraceuticals could restore the balance of metabolic cofactors and essential nutrients in affected tissues, potentially attenuating the inflammatory cascade associated with infection and tissue injury, as in endodontic disease [3, 4] . To date, there is only limited experimental evidence and a lack of  \nARTICLE HISTORY  \nReceived 29 September 2025 Accepted 14 October 2025  \nKEYWORDS  \nNutraceuticals; endodontics; systemic health; oral health  \nclinical trials evaluating whether adjunctive nutraceuticals can support periapical healing or help control the local and systemic inflammation associated with endodontic infections. This knowledge gap is noteworthy and demands attention, given the interplay between endodontic disease and systemic health.  \nIt is essential to consider the interplay between apical periodontitis (AP) and the host’s systemic condition, particularly their immune and nutritional status, when exploring new adjunctive therapies. AP is not merely a local pathology; increasing evidence suggests that an individual’s immune competence influences the initiation and progression of AP, as well as treatment response and healing outcomes [5, 6] . An exaggerated local immune-inflammatory reaction in a periapical lesion can also have systemic spillover effects, potentially triggering or exacerbating systemic conditions in predisposed individuals, although the exact biological pathways remain incompletely understood [5–7] . This host-pathogen interaction is significant, especially given t","cbCaim3W9Nfo26aT","https://ap.wps.com/l/cbCaim3W9Nfo26aT","pdf",187851,"English","# Introduction\n## Mechanisms and complementary role of nutraceuticals\n# Dental and medical applications\n## Evidence in periodontology and other specialties\n# Gap and rationale in endodontics\n## Host-pathogen interaction and systemic considerations\n# Need for clinical evidence","[{\"question\":\"What distinguishes nutraceuticals from conventional pharmaceuticals in this letter?\",\"answer\":\"Nutraceuticals are presented as complementary agents for prevention and treatment rather than replacements for standard therapies.\"},{\"question\":\"Why is apical periodontitis discussed as more than a local condition?\",\"answer\":\"The letter explains that immune-inflammatory reactions in periapical lesions can have systemic spillover effects in predisposed individuals.\"},{\"question\":\"What evidence gap exists regarding endodontics?\",\"answer\":\"The letter states that only limited experimental evidence and a lack of clinical trials evaluate whether adjunctive nutraceuticals support periapical healing or control local and systemic inflammation.\"}]","Nutraceuticals for oral health - scientific rationale and clinical potential in endodontics | PDF",1790705190]