[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-371471-105":59,"doc-detail-371471-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","nurse-night-shift-work-and-risk-of-gastrointestinal-cancers","Nurse night shift work and risk of gastrointestinal cancers","","Night-shift employment is increasing worldwide and is associated with biological challenges such as exposure to artificial light at night and circadian rhythm disruption. A growing body of evidence links these conditions to carcinogenesis through mechanisms including melatonin suppression, physiological alterations, lifestyle changes, and reduced vitamin D from inadequate sunlight. Colorectal cancer remains a major global cause of cancer-related death, and gastrointestinal cancers continue to impose substantial morbidity and mortality. This review synthesizes how night-shift work perturbs circadian regulation and may drive gastrointestinal cancer development.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nurse-night-shift-work-and-risk-of-gastrointestinal-cancers/371471/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nurse-night-shift-work-and-risk-of-gastrointestinal-cancers/371471.png","ImageObject",300,407,{"name":92,"@type":93},"Kyle","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is night-shift work considered potentially carcinogenic?","Question",{"text":113,"@type":114},"Night-shift work disrupts circadian rhythms and reduces melatonin due to nighttime light exposure, along with other physiological and lifestyle changes that may contribute to carcinogenic processes.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What global cancer burden does the article focus on?",{"text":118,"@type":114},"The article highlights colorectal cancer as a major public health challenge and notes that other gastrointestinal cancers also contribute to global morbidity and mortality.",{"name":120,"@type":111,"acceptedAnswer":121},"How does the review describe the etiology of colorectal cancer?",{"text":122,"@type":114},"It discusses that inherited mutations explain only a minority of cases and emphasizes environmental and lifestyle influences, with sporadic colorectal cancer involving mutations such as in the APC gene and later changes to tumor suppressor genes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},371471,1790718650,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},3985741905716,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","TYPE Review  \nPUBLISHED 28 April 2025  \nDOI 10.3389/fpubh.2025.1532623  \nOPEN ACCESS  \nEDITED BY  \nNange Jin,  \nUniversity of Houston, United States  \nREVIEWED BY  \nQuan Yi,  \nCapital Medical University, China Xiaoqin Liu,  \nTexas A&M Health Science Center, United States  \n*CORRESPONDENCE  \nXiaojun Li  \n [lxj101100@immu.edu.cn](lxj101100@immu.edu.cn)  \nRECEIVED 22 November 2024  \nACCEPTED 07 April 2025  \nPUBLISHED 28 April 2025  \nCITATION  \nGuo L and Li X (2025) Nurse night shift work and risk of gastrointestinal cancers.  \nFront. Public Health 13:1532623 .  \ndoi: 10.3389/fpubh.2025.1532623  \nCOPYRIGHT  \n© 2025 Guo and Li. This is an open-access article distributed under the terms of the  \nCreative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nNurse night shift work and risk of gastrointestinal cancers  \nLin Guo 1 and Xiaojun Li 2*  \n1 Medical Simulated Center, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China, 2School of Nursing, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China  \nThe prevalence of night-shift employment is on the rise among full-time and part-time workers globally. Those engaged in night-shift work encounter various biological challenges, including exposure to artificial light during nighttime and disruptions to their circadian rhythms. These factors, along with changes in daily routines and activities, may pose significant risks to the health of night workers. Notably, the number of individuals working overtime or on night shifts has increased across various sectors, particularly in transportation, healthcare, and manufacturing. The International Agency for Research on Cancer (IARC) has classified nightshift work as probably carcinogenic to humans (IARC Group 2A) . Subsequent research has identified several potential mechanisms through which night-shift work may contribute to carcinogenicity: (1) disruption of circadian rhythms,(2) suppression of melatonin levels due to nighttime light exposure,(3) physiological alterations,(4) lifestyle changes, and (5) reduced vitamin D levels resulting from inadequate sunlight exposure. Colorectal cancer (CRC) poses a significant public health challenge, ranking as the second leading cause of cancer-related death worldwide in 2020. Other than CRC, other gastrointestinal cancers are also creating a great global health issue because of their morbidity and mortality rates. In this review, we highlight the role of night shifts in disturbing circadian rhythm and how this action leads to carcinogenesis in the GI tract.  \nKEYWORDS  \ncircadian, night shift, gastrointestinal, cancer, colon cancer, colorectal cancer  \n1 Gastrointestinal cancers  \n1.1 Epidemiology  \nColorectal cancer poses a significant public health challenge, ranking as the second leading cause of cancer-related death worldwide in 2020, according to GLOBOCAN estimates from the International Agency for Research on Cancer (IARC) ( 1) . This analysis reveals a stark geographic disparity in CRC mortality, with Europe exhibiting the highest age-standardized mortality rate (ASMR) at 12.3 per 100,000 person-years, while Africa and the Eastern Mediterranean region (EMRO) report the lowest rates at 5.6 and 5.3, respectively. Furthermore, a notable gender a disparity exists, with men experiencing a significantly higher ASMR (11.0) compared to women (7.2) ( 1). CRC also emerged as the third most prevalent cancer globally in 2020, with an estimated 1,931,590 new cases reported. Similar to mortality trends, geographic variations in incidence rates were observed, with Europe exhibiting the highest age-standardized incidence rate (ASR) at 30.4, while EMRO and Africa display","cbCaimmu9KwFKkxU","https://ap.wps.com/l/cbCaimmu9KwFKkxU","pdf",653093,"English","# 1 Gastrointestinal cancers\n## 1.1 Epidemiology\n## 1.2 Etiology","[{\"question\":\"Why is night-shift work considered potentially carcinogenic?\",\"answer\":\"Night-shift work disrupts circadian rhythms and reduces melatonin due to nighttime light exposure, along with other physiological and lifestyle changes that may contribute to carcinogenic processes.\"},{\"question\":\"What global cancer burden does the article focus on?\",\"answer\":\"The article highlights colorectal cancer as a major public health challenge and notes that other gastrointestinal cancers also contribute to global morbidity and mortality.\"},{\"question\":\"How does the review describe the etiology of colorectal cancer?\",\"answer\":\"It discusses that inherited mutations explain only a minority of cases and emphasizes environmental and lifestyle influences, with sporadic colorectal cancer involving mutations such as in the APC gene and later changes to tumor suppressor genes.\"}]","Nurse night shift work and risk of gastrointestinal cancers | PDF",1790192148]