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Although NBM involvement is well established in Alzheimer’s disease (AD), its contribution to frontotemporal dementia (FTD) remains uncertain. Method: Resting-state fMRI and T1-weighted scans were collected from healthy controls (n = 66), AD (n = 50), and FTD subtypes (bvFTD, PLA, PPA, PNFA, SemD). Seed-based FC analyses used FSL with left and right NBM seeds; group comparisons used cluster-based thresholds, Kruskal–Wallis, and Bonferroni-adjusted pairwise tests, with voxel-based morphometry for cortical atrophy patterns. Results: HC showed stronger NBM connectivity than AD in multiple regions, and significant connectivity differences emerged across HC and FTD subtypes. Conclusion: Distinct NBM functional connectivity and cortical atrophy patterns differentiate HC, AD, and FTD subtypes.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nucleus-basalis-of-meynert-functional-connectivity-and-morphometry-in-alzheimers-disease-and-frontotemporal-dementia-poster-presentation/459220/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nucleus-basalis-of-meynert-functional-connectivity-and-morphometry-in-alzheimers-disease-and-frontotemporal-dementia-poster-presentation/459220.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus of this study on the nucleus basalis of Meynert (NBM)?","Question",{"text":112,"@type":113},"The study examines NBM functional connectivity and NBM/cortical volume changes across Alzheimer’s disease, healthy controls, and multiple frontotemporal dementia subtypes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which imaging methods and analysis approach were used?",{"text":117,"@type":113},"Resting-state fMRI and T1-weighted scans were analyzed with seed-based functional connectivity in FSL using left and right NBM as seeds, with Kruskal–Wallis and Bonferroni-corrected pairwise comparisons where applicable. Voxel-based morphometry was used to assess cortical atrophy patterns.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key findings when comparing healthy controls and Alzheimer’s disease?",{"text":121,"@type":113},"Healthy controls showed stronger NBM connectivity than Alzheimer’s disease in regions including the hippocampus/parahippocampal gyrus, frontal pole, paracingulate cortex, precuneus, and lateral occipital cortex.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},459220,1790755471,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":129,"read_time":24,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","DOI: 10. 1002/alz70856_105620  \nBIOMARKERS  \nPOSTER PRESENTATION  \nNEUROIMAGING  \nNucleus Basalis of Meynert: Functional Connectivity and Morphometry in Alzheimer’s Disease and Frontotemporal Dementia  \nChristine Kindler1, 2, 3  Grace Gillis4, 5  Gaurav V Bhalerao5, 6   \nJesper L. R. Andersson6  Paul McCarthy6  Carolin Miklitz2, 3  Tony Stoecker2, 7  Gabor C Petzold 1, 2  Ludovica Griffanti4, 5, 6  DESCRIBE-FTD investigators, DELCODE investigators, DANCER investigators; * these authors contributed equally  \n1 Division of Vascular Neurology, Department of Neurology, University Hospital Bonn, Bonn, NRW, Germany  \n2 German Center for Neurodegenerative Diseases (DZNE), Bonn, NRW, Germany  \n3 Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, Bonn, NRW, Germany  \n4 Oxford Health NHS Foundation Trust, Oxford, Oxfordshire, United Kingdom  \n5 Department of Psychiatry, Oxford Centre for Human Brain Activity (OHBA), Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, Oxfordshire, United Kingdom  \n6 Nuffield Department of Clinical Neurosciences, Oxford Centre for Functional MRI of the Brain (FMRIB), Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, Oxfordshire, United Kingdom  \n7 Department of Physics and Astronomy, University of Bonn, Bonn, NRW, Germany  \nCorrespondence  \nChristine Kindler, Division of Vascular Neurology, Department of Neurology, University Hospital Bonn, Bonn, NRW, Germany. [Email:](Email: christine.kindler@ukbonn.de)[ christine.kindler@ukbonn.de](Email: christine.kindler@ukbonn.de)  \nAbstract  \nBackground: The nucleus basalis of Meynert (NBM) is crucial for learning, attention, and memory. While its involvement in Alzheimer’s disease (AD) has been widely reported, the role in frontotemporal dementia (FTD) remains unclear. Here we examined NBM functional connectivity (FC) as well as NBM and cortical volume changes in AD, healthy controls (HC), and FTD subtypes: behavioral variant FTD (bvFTD), unclassified primary progressive aphasia (PPA), progressive nonfluent aphasia (PNFA), semantic dementia (SemD), and progressive logopenic aphasia (PLA). Method: Resting-state fMRI and T1-weighted scans were collected from HC (n = 66), individuals with AD (n = 50), bvFTD (n = 63), PLA (n = 18), PPA (n = 20), PNFA (n = 32), and SemD (n = 15). We performed seed-based FC analyses in FSL with left and right NBM as seeds. We compared HC with AD (cluster-based threshold z > 2. 3, p \u003C 0.05). Significant clusters were used to extract mean FC for the other groups. We then compared FC values and normalized NBM volumes across HC and FTD subtypes using the Kruskal–Wallis test, followed by Bonferroni-corrected pairwise comparisons where applicable. Voxel-based morphometry (VBM) was conducted to explore cortical atrophy patterns.  \nResult: HC showed stronger NBM connectivity than AD in the hippocampus/parahippocampal gyrus, frontal pole, paracingulate cortex, precuneus, and lateral occipital cortex (Figure 1, left NBM results). Across HC and FTD subtypes, we found significant group differences forthe paracingulate (H = 36. 15, p \u003C 0.001) and lateral occipital cortex (H = 18. 25, p = 0.003). Connectivity was higher in bvFTD, PPA, and LPA than in HC, with the strongest effect for bvFTD in the paracingulate cortex  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Alzheimer’s Association. Alzheimer’s & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer’s Association.  \nAlzheimer’s Dement. 2025;21(Suppl. 2):e105620.  \n[https://doi.org/10.1002/alz70856_105620](https://doi.org/10.1002/alz70856_105620)  \nwi[leyonlinelibrary.com/journal/alz](leyonlinelibrary.com/journal/alz)  \n1of2  \nBIOMARKERS  \n(r = 0.48) and moderate effects across other contrasts (r = 0.28–0.42, all p \u003C 0.020). Volumetric ","cbCaiicyIhnOmbDd","https://ap.wps.com/l/cbCaiicyIhnOmbDd","pdf",356656,"English","# Abstract\n## Background\n## Method\n## Result\n## Conclusion","[{\"question\":\"What is the main focus of this study on the nucleus basalis of Meynert (NBM)?\",\"answer\":\"The study examines NBM functional connectivity and NBM/cortical volume changes across Alzheimer’s disease, healthy controls, and multiple frontotemporal dementia subtypes.\"},{\"question\":\"Which imaging methods and analysis approach were used?\",\"answer\":\"Resting-state fMRI and T1-weighted scans were analyzed with seed-based functional connectivity in FSL using left and right NBM as seeds, with Kruskal–Wallis and Bonferroni-corrected pairwise comparisons where applicable. Voxel-based morphometry was used to assess cortical atrophy patterns.\"},{\"question\":\"What were the key findings when comparing healthy controls and Alzheimer’s disease?\",\"answer\":\"Healthy controls showed stronger NBM connectivity than Alzheimer’s disease in regions including the hippocampus/parahippocampal gyrus, frontal pole, paracingulate cortex, precuneus, and lateral occipital cortex.\"}]","Nucleus Basalis of Meynert - Functional Connectivity and Morphometry in Alzheimer’s Disease and Frontotemporal Dementia - Poster Presentation | PDF"]