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This study analyzes transcriptome data of muscle-invasive bladder cancer to characterize neuroendocrine-like differentiation, focusing on β-catenin localization, transcription factors, and chromatin remodeling complexes. Results show a significant link between β-catenin localization and neuroendocrine differentiation, with YY1, E2F family, and Polycomb repressive complex enrichment in β-catenin-positive tumors. These findings clarify molecular complexity and support improved diagnostic and therapeutic targeting.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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question does the study address regarding bladder cancer heterogeneity?","Question",{"text":63,"@type":64},"It investigates the molecular basis of neuroendocrine-like differentiation in muscle-invasive bladder cancer, specifically the role of β-catenin localization.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the neuroendocrine-like molecular landscape investigated?",{"text":68,"@type":64},"By analyzing transcriptome data and applying a molecular classification tool to uncover differentiation-related molecular characteristics.",{"name":70,"@type":61,"acceptedAnswer":71},"What molecular relationship did the study find involving β-catenin?",{"text":72,"@type":64},"It found a significant correlation between β-catenin localization and neuroendocrine differentiation in muscle-invasive bladder 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ART I C L E  \nNucleocytoplasmic β-catenin expression contributes toneuroendocrine differentiation in muscle invasive bladder cancer  \nBurcu Akman1  | Ahmet Bursalı1 | Mustafa Gürses2 | Aslı Suner3 |  \nGökhan Karakülah1,4 | Uğur Mungan2 | Kutsal Yörükoğlu5 | Serap Erkek-Ozhan1  \n1Basic and Translational Research Program, İzmir Biomedicine and Genome Center, İzmir, Turkey  \n2Department of Urology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey  \n3 Department of Biostatistics and Medical Informatics, Faculty of Medicine, Ege University, Bornova, Turkey  \n4İzmir International Biomedicine and Genome Institute, Dokuz Eylül University,İzmir, Turkey  \n5Department of Pathology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey  \nCorrespondence  \nKutsal Yörükoğlu, Department of Pathology, Faculty of Medicine, Dokuz Eylül University, İnciraltı mahallesi, Mithatpaşa caddesi, No:1606 Balçova,İzmir 35340, Turkey.  \nEmail: [kutsal.yorukoglu@deu.edu.tr](kutsal.yorukoglu@deu.edu.tr)  \n[Serap Erkek-Ozhan](Serap Erkek-Ozhan), Disease Epigenetics Group, Izmir Biomedicine and Genome Center, Dokuz Eylül University Health Campus, Mithatpaşa Caddesi No: 58/5, Balçova, İzmir 35340, Turkey.  \nEmail: [serap.erkek@ibg.edu.tr](serap.erkek@ibg.edu.tr)  \nFunding information  \nTürkiye Bilimsel ve Teknolojik Araştırma Kurumu, Grant/Award Number: 120C129; European Molecular Biology Organization, Grant/Award Number: IG 4148  \nAbstract  \nBladder cancers are heterogeneous in nature, showing diverse molecular profiles and histopathological characteristics, which pose challenges for diagnosis and treatment. However, understanding the molecular basis of such heterogeneity has remained elusive. This study aimed to elucidate the molecular landscape of neuroendocrine-like bladder tumors, focusing on the involvement of β-catenin localization. Analyzing the transcriptome data and benefiting from the molecular classification tool, we undertook an in-depth analysis of muscle-invasive bladder cancers to uncover the molecular characteristics of the neuroendocrine-like differentiation. The study explored the contribution of transcription factors and chromatin remodeling complexes to neuroendocrine differentiation in bladder cancer. The study revealed a significant correlation between β-catenin localization and neuroendocrine differentiation in muscle-invasive bladder tumors, highlighting the molecular complexity of neuroendocrine-like tumors. Enrichment of YY1 transcription factor, E2F family members, and Polycomb repressive complex components in β-catenin-positive tumors suggest their potential contribution to neuroendocrine phenotypes. Our findings contribute valuable insights into the molecular complexity of neuroendocrine-like bladder tumors. By identifying potential therapeutic targets and refining diagnostic strategies, this study advances our understanding of endocrinology in the context of bladder cancer. Further investigations into the functional implications of these molecular relationships are warranted to enhance our knowledge and guide future therapeutic interventions.  \nK E Y WO R D S  \nbladder cancer, molecular subtype, neuroendocrine differentiation, Polycomb repressive complex, transcriptomics  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.  \n© 2024 The Author(s) . Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.  \n1 | INTRODUCTION  \nBladder cancer is one of the most common urologic malignancies worldwide (GLOBOCAN 2020, [https://www.wcrf.org/cance](https://www.wcrf.org/cance)r-trends/bladder-cancer-statistics/) . Bladder cancers are classified as nonmuscle invasive bladder cancers and muscle-invasive bladder cancers (MIBC) based on the infi","cbCais68t62sXVcw","https://ap.wps.com/l/cbCais68t62sXVcw","pdf",9963040,13,"English","# Introduction\n## Molecular heterogeneity in bladder cancer\n## Molecular classification and transcriptome profiling\n## Neuroendocrine-like subtypes and clinical relevance","[{\"question\":\"What question does the study address regarding bladder cancer heterogeneity?\",\"answer\":\"It investigates the molecular basis of neuroendocrine-like differentiation in muscle-invasive bladder cancer, specifically the role of β-catenin localization.\"},{\"question\":\"How was the neuroendocrine-like molecular landscape investigated?\",\"answer\":\"By analyzing transcriptome data and applying a molecular classification tool to uncover differentiation-related molecular characteristics.\"},{\"question\":\"What molecular relationship did the study find involving β-catenin?\",\"answer\":\"It found a significant correlation between β-catenin localization and neuroendocrine differentiation in muscle-invasive bladder tumors.\"}]","Nucleocytoplasmic β-catenin expression contributes to neuroendocrine differentiation in muscle invasive bladder cancer | PDF",1789998836,33]