[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331895-105":59,"doc-detail-331895-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","novel-role-of-lncrnas-regulatory-network-in-papillary-thyroid-cancer-review","Novel role of lncRNAs regulatory network in papillary thyroid cancer - Review","","Papillary thyroid cancer (PTC) is the most common endocrine malignancy, and its incidence continues to rise worldwide. Noncoding RNAs, especially lncRNAs, are key regulators in PTC progression and may serve as prognostic biomarkers. MicroRNAs and epithelial-mesenchymal transition (EMT)-associated proteins also show promise for diagnosis and therapy, but the links between lncRNAs, miRNAs, and EMT-related factors require clarification. This review summarizes recent advances and highlights lncRNAs-miRNAs-protein and lncRNAs-EMT regulatory mechanisms to support prognosis evaluation and potential diagnostic and therapeutic strategies targeting the lncRNA network.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/novel-role-of-lncrnas-regulatory-network-in-papillary-thyroid-cancer-review/331895/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/novel-role-of-lncrnas-regulatory-network-in-papillary-thyroid-cancer-review/331895.png","ImageObject",300,407,{"name":92,"@type":93},"Anda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What makes papillary thyroid cancer (PTC) a focus for molecular research?","Question",{"text":112,"@type":113},"PTC is the most common thyroid cancer subtype and its incidence keeps increasing. Improving diagnosis and clinical management increasingly relies on molecular and biomarker insights beyond conventional imaging and treatment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do lncRNAs contribute to PTC progression and clinical value?",{"text":117,"@type":113},"lncRNAs play crucial roles in PTC progression and are discussed as prognostic biomarkers. The review emphasizes how lncRNAs can be linked with miRNAs and EMT-associated pathways.",{"name":119,"@type":110,"acceptedAnswer":120},"What regulatory mechanisms are highlighted in the review?",{"text":121,"@type":113},"The review summarizes two molecular regulatory mechanisms: lncRNAs-miRNAs-protein signaling axes and lncRNAs-EMT pathways. It also explains that biomarker types are interconnected in PTC.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331895,1790194487,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","Biochemistry and Biophysics Reports 38 (2024) 101674  \nContents lists available at ScienceDirect  \nBiochemistry and Biophysics Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/bbrep)[ www.elsevier.com/locate/bbrep](homepage: www.elsevier.com/locate/bbrep)  \n| Novel role of lncRNAs regulatory network in papillary thyroid cancer Yuanhao Sua, Lin Meib, Tiantian Jiang a, Zhidong Wang a, **, Yuanyuan Jib, *\u003Cbr>a Department of General Surgery, The Second Affiliated Hospital, Xi’an Jiaotong, University, Xi’an, 710004, China\u003Cbr>b Scientific Research Center and Precision Medical Institute, The Second Affiliated, Hospital, Xi’an Jiaotong University, Xi’an, 710004, China |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords:\u003Cbr>Papillary thyroid cancer lncRNAs\u003Cbr>miRNAs EMT Prognosis Diagnosis |  | Papillary thyroid cancer (PTC) is the most common endocrine malignancy. The incidence of PTC has increased annually worldwide. Thus, PTC diagnosis and treatment attract more attention. Noncoding RNAs (lncRNAs) play crucial roles in PTC progression and act as prognostic biomarkers. Moreover, microRNAs (miRNAs) and epithelial-mesenchymal transition (EMT)-associated proteins have potential biomarkers for diagnosing and treating PTC. However, the correlation of lncRNAs with miRNAs and EMT-associated proteins needs further clarification. The present review highlights the recent advances of lncRNAs in PTC. We significantly summarized the two molecular regulatory mechanisms in PTC progress, including lncRNAs-miRNAs-protein signaling axes and lncRNAs-EMT pathways. This review will help our understanding of the association between lncRNAs and PTC and may assist us in evaluating the prognosis for PTC patients. Taken together, targeting the lncRNAs regulatory network has promising applications in diagnosing and treating PTC. |\n\n1. Introduction  \nOver the past few decades, the incidence of thyroid cancer has been steadily increasing worldwide [1–3]. Among thyroid cancer cases, papillary thyroid cancer (PTC) is the most common histological subtype, accounting for 89.1% of all cases [4]. As the most common endocrine malignancy [5], thyroid cancer diagnosis and treatment attract more attention. In addition to conventional imaging and treatment methods such as surgery and radiation therapy, molecular and biomarker analysis has become an essential supplement to traditional pathological assessments of thyroid cancer in recent years [6]. These tools represent valuable resources for improving thyroid cancer diagnosis and clinical management [7]. As indicated by research, with advancements in early tumor diagnosis and novel treatment approaches such as proteogenomics, DNA methylation, lncRNAs, and microRNAs (miRNAs), the survival rate of cancer patients is improving [8]. Several key points include: specific biomarkers participate in thyroid cancer cell processes like proliferation, migration, and apoptosis [9]; some relate to the tumor microenvironment, affecting prognosis [10]; other biomarkers help tumor cells evade the immune system [11,12], highlighting immunotherapy’s potential as an effective treatment option.  \nAs mentioned earlier, the majority of thyroid cancers are PTC. As a  \nwell-differentiated subtype of malignant tumors, PTC is generally considered to have a good prognosis [13]. However, studies have indicated that PTC can progress toward a poorly differentiated state, significantly decreasing life expectancy [14,15]. Furthermore, the diagnosis of PTC currently relies mainly on histopathological biopsy and fine-needle aspiration biopsy. These diagnostic methods are time-consuming in clinical practice, and the sampled tissues can significantly influence the test results. Therefore, it is crucial to identify tumor biomarkers that can be used for early and precise diagnosis. Here are some common PTC biomarkers:1.long noncoding RNAs (lncRNAs): lncRNAs also display altered expression levels in PTC, such as NE","cbCaictdbmAwGJix","https://ap.wps.com/l/cbCaictdbmAwGJix","pdf",3682586,"English","# Introduction\n## Epidemiology and clinical attention to PTC\n## Molecular and biomarker analysis\n## Biomarkers: lncRNAs, proteins, and miRNAs\n## Biomarker interconnections and review focus","[{\"question\":\"What makes papillary thyroid cancer (PTC) a focus for molecular research?\",\"answer\":\"PTC is the most common thyroid cancer subtype and its incidence keeps increasing. Improving diagnosis and clinical management increasingly relies on molecular and biomarker insights beyond conventional imaging and treatment.\"},{\"question\":\"How do lncRNAs contribute to PTC progression and clinical value?\",\"answer\":\"lncRNAs play crucial roles in PTC progression and are discussed as prognostic biomarkers. The review emphasizes how lncRNAs can be linked with miRNAs and EMT-associated pathways.\"},{\"question\":\"What regulatory mechanisms are highlighted in the review?\",\"answer\":\"The review summarizes two molecular regulatory mechanisms: lncRNAs-miRNAs-protein signaling axes and lncRNAs-EMT pathways. It also explains that biomarker types are interconnected in PTC.\"}]","Novel role of lncRNAs regulatory network in papillary thyroid cancer - Review | PDF",1789995645,23]