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Retrospective UTUC cohort stratified into favorable, intermediate, and poor LIPI groups using LIPI derived from neutrophil-to-lymphocyte ratio with lactate dehydrogenase. Non-urothelial tract recurrence-free survival was analyzed via Kaplan-Meier and Cox regression to identify risk factors. Results show poor/intermediate LIPI associated with worse NUTRFS and improved risk assessment when combined with advanced pathological stage and lymph node metastasis.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/novel-preoperative-immune-prognostic-index-for-predicting-outcomes-in-patients-undergoing-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma/368265/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/novel-preoperative-immune-prognostic-index-for-predicting-outcomes-in-patients-undergoing-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma/368265.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the lung immune prognostic index (LIPI) used in this study?","Question",{"text":63,"@type":64},"LIPI is determined by the derived neutrophil-to-lymphocyte ratio together with lactate dehydrogenase level. It is applied here as a preoperative biomarker for UTUC.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were outcomes evaluated for patients undergoing radical nephroureterectomy?",{"text":68,"@type":64},"Non-urothelial tract recurrence-free survival was assessed using Kaplan-Meier analysis. Cox regression analyses were used to identify risk factors for recurrence-free survival.",{"name":70,"@type":61,"acceptedAnswer":71},"Does LIPI improve prognostic assessment when combined with other clinical factors?",{"text":72,"@type":64},"Yes. Combining LIPI status with pathological stages (pT3-4/ypT2-4) and lymph node metastasis status improved postoperative non-urothelial tract recurrence prognosis assessment.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},368265,1790621415,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":123,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","doi: 10.21873/invivo.13885  \nNovel Preoperative Immune Prognostic Index for Predicting Outcomes in Patients Undergoing Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma  \nKEN SHIBATA1\\#, KOSUKE IWATANI1,2, YU IMAI1, KENTARO YOSHIHARA1,3, KEIICHIRO MIYAJIMA1,  \nWATARU FUKUOKAYA1, KAGENORI ITO1, TARO IGARASHI1, TAKAFUMI YANAGISAWA1, KOJIRO TASHIRO1,3, SHUSUKE TSUZUKI1, STEFFI KAR KEI YUEN4, JEREMY YUEN‐CHUN TEOH4, BRENDANA. YANADA1,5, YUSUKE KOIKE1, TATSUYA SHIMOMURA1, HIROKI YAMADA1,3, AKIRA FURUTA1, JUN MIKI1,2, TAKAHIRO KIMURA1, and  \nFUMIHIKO URABE1\\#, on behalf of the JIKEI‐YAYOI Collaborative Group  \n1 Department of Urology, The Jikei University School of Medicine, Tokyo, Japan;  \n2 Department of Urology, Jikei University Kashiwa Hospital, Chiba, Japan;  \n3 Department of Urology, Jikei Katsushika Medical Center, Tokyo, Japan;  \n4S. H. Ho Urology Centre, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, S.A. R.; 5 Department of Surgery, The University of Melbourne, Parkville, Australia  \nAbstract  \nBackground/Aim: The lung immune prognostic index (LIPI), which is determined by assessing the derived neutrophil‑ to‑lymphocyte ratio in conjunction with the level of lactate dehydrogenase, predicts outcomes in various cancers. Its utility as a preoperative biomarker in upper tract urothelial carcinoma (UTUC) patients remains unexplored. Patients and Methods: This is a retrospective study of UTUC patients who underwent radical nephroureterectomy. Patients were stratified into favorable, intermediate, and poor LIPI groups. Non‑urothelial tract recurrence‑free survival (NUTRFS) was evaluated using Kaplan‑Meier analysis, and Cox regression analyses were performed to identify risk factors for NUTRFS.  \nResults: A total of 567 UTUC patients were included, with 46.4% in the favorable, 44.6% in the intermediate, and 9.0% in the poor (9.0%) LIPI groups. The median participant age was 74 years, with a median follow‑up of 26 months. Kaplan‑ Meier curves demonstrated that NUTRFS was significantly worse in patients with poor and intermediate LIPI scores than in those with favorable LIPI scores. Furthermore, combining LIPI status with pathological stages (pT3‑4/ypT2‑4) and lymph node metastasis status improved postoperative non‑urothelial tract recurrence prognosis assessment. Conclusion: The preoperative LIPI is a prognostic indicator for patients with UTUC undergoing nephroureterectomy.  \nIts predictive accuracy improves when combined with advanced pathological stages and lymph node metastasis status. Keywords: Upper tract urothelial carcinoma, lung immune prognostic index, LIPI, preoperative biomarker, multicenter study.  \n\\#These Authors contributed equally to this study.  \n✉  \nFumihiko Urabe, MD, Ph.D., Department of Urology, The Jikei University School of Medicine, Tokyo, Japan. Tel: +81  \n334331111 ex: 3561, e‑mail: [furabe0809@gmail.com](furabe0809@gmail.com)  \nReceived November 9, 2024 | Revised November 18, 2024 | Accepted November 19, 2024  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n©2025 The Author(s) . Anticancer Research is published by the International Institute of Anticancer Research.  \nIntroduction  \nUpper tract urothelial carcinoma (UTUC) is an uncommon malignancy, constituting about 10% of renal and 5% of urothelial tumors, with a growing incidence over recent years (1, 2). Typically, UTUC is more prevalent in the renal pelvis than in the ureter at the time of diagnosis (3). The standard approach for managing this disease, aimed at long‑term control, involves radical nephroureterectomy together with excision of the bladder cuff. Despite this aggressive treatment strategy, there remains a significant risk, approximately 30%, of recurrence or mortality post‑ surgery (4‑6). Therefore, better preoperative prognostic biomarkers for pa","cbCaijeMVrZZJEJu","https://ap.wps.com/l/cbCaijeMVrZZJEJu","pdf",995192,"English","# Background/Aim\n# Patients and Methods\n## Patients\n# Results\n# Conclusion\n# Introduction\n# Patients and Methods","[{\"question\":\"What is the lung immune prognostic index (LIPI) used in this study?\",\"answer\":\"LIPI is determined by the derived neutrophil-to-lymphocyte ratio together with lactate dehydrogenase level. It is applied here as a preoperative biomarker for UTUC.\"},{\"question\":\"How were outcomes evaluated for patients undergoing radical nephroureterectomy?\",\"answer\":\"Non-urothelial tract recurrence-free survival was assessed using Kaplan-Meier analysis. Cox regression analyses were used to identify risk factors for recurrence-free survival.\"},{\"question\":\"Does LIPI improve prognostic assessment when combined with other clinical factors?\",\"answer\":\"Yes. Combining LIPI status with pathological stages (pT3-4/ypT2-4) and lymph node metastasis status improved postoperative non-urothelial tract recurrence prognosis assessment.\"}]","Novel Preoperative Immune Prognostic Index for Predicting Outcomes in Patients Undergoing Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma | PDF",1790175941,25]