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Pan-cancer results show that C10orf90 expression varies among tumor types and carries clinical diagnostic and prognostic significance. In selected cancers, expression associates with CNV, DNA methylation, immune subtypes, immune cell infiltration, and drug sensitivity. In COAD specifically, C10orf90 links to multiple colorectal cancer processes. 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Novel Oncogenic Value of C10orf90 in Colon Cancer Identified as a Clinical Diagnostic and Prognostic Marker. Int. J. Mol. Sci. 2024, 25, 10496 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms251910496  \nAcademic Editors: Nam Deuk Kim, Stephanie J. Tuminello and Emanuela Taioli  \nReceived: 20 July 2024  \nRevised: 21 September 2024  \nAccepted: 22 September 2024  \nPublished: 29 September 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nGuangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Department of Biotechnology, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China;  \n[dong123123122023@163.com](dong123123122023@163.com) (C.R.); [18984776137@163.com](18984776137@163.com) (Y.Z.); [staog5174@gmail.com](staog5174@gmail.com) (D.C.);  \n[zhumengyihi@163.com](zhumengyihi@163.com) (M.Z.); [17531087793@163.com](17531087793@163.com) (P.Y.)  \n* Correspondence: [rxzhang@gdpu.edu.cn](rxzhang@gdpu.edu.cn) (R.Z.); [yanli@gdpu.edu.cn](yanli@gdpu.edu.cn) (Y.L.)  \nAbstract: C10orf90, a tumor suppressor, can inhibit the occurrence and development of tumors. Therefore, we investigated the gene function of C10orf90 in various tumors using multiple pan-cancer datasets. Pan-cancer analysis results reveal that the expression levels of C10orf90 vary across different tumors and hold significant value in the clinical diagnosis and prognosis of patients with various tumors. In some cancers, the expression level of C10orf90 is correlated with CNV, DNA methylation, immune subtypes, immune cell infiltration, and drug sensitivity in the tumors. In particular, in COAD, the C10orf90 gene is implicated in multiple processes associated with COAD. Cell experiments demonstrate that C10orf90 suppresses the proliferation and migration of colon cancer cells while promoting apoptosis. In summary, C10orf90 plays a role in the onset and progression of various cancers and could potentially serve as an effective diagnostic and prognostic marker for cancer patients. Notably, in COAD, C10orf90 inhibits the proliferation and migration of colon cancer cells, induces apoptosis, and is linked to the advancement of colon cancer.  \nKeywords: C10orf90; pan-cancer; COAD; comprehensive analysis  \n1. Introduction  \nThe mechanisms underlying the initiation of cancer remain poorly understood. Notably, the DNA damage response and defective repair processes may contribute to increased genomic instability, a critical factor in cancer development. With the vigorous development of genomics, researchers have discovered that specific DNA segments on chromosomes tend to exhibit a significant number of gaps and breaks in a highly non-random manner under replication stress. This phenomenon can lead to instability in chromosomal genes, designating these specific breakage regions as fragile sites [1] .  \nChromosome 10 open reading frame 90 (C10orf90), also known as D7Ertd443e or FATS, is a fragile site gene located on chromosome 10q26.2, within the fragile region of chromosome FRA10F [2] . The C10orf90 gene is rich in AT repeat sequences, with up to 56.8% AT base pairs. The cross-arrangement of double-stranded AT dinucleotide repeat sequences represents a fragile link, which is prone to gene breakage at this frag","cbCailVHXnISAwQa","https://ap.wps.com/l/cbCailVHXnISAwQa","pdf",9536082,23,"English","# Introduction\n## DNA damage response and fragile sites\n## C10orf90 gene location and replication instability\n# Abstract\n## Pan-cancer expression and clinical value\n## COAD-specific mechanisms\n## Cell experiment validation","[{\"question\":\"What is C10orf90 and why is it relevant to cancer?\",\"answer\":\"C10orf90 is characterized as a tumor suppressor that can inhibit tumor occurrence and development. Its expression and molecular links make it relevant for understanding cancer biology and clinical behavior.\"},{\"question\":\"How does the study assess C10orf90 across cancers?\",\"answer\":\"The study uses multiple pan-cancer datasets to evaluate expression patterns and associations with clinical and molecular features. It then highlights cancer-specific relationships, especially in COAD.\"},{\"question\":\"What experimental results support C10orf90’s role in colon cancer?\",\"answer\":\"Cell experiments show that C10orf90 suppresses proliferation and migration of colon cancer cells while promoting apoptosis, indicating an inhibitory functional role in colon cancer progression.\"}]","Novel Oncogenic Value of C10orf90 in Colon Cancer Identified as a Clinical Diagnostic and Prognostic Marker | PDF",1789993188,58]