[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-451062-en":59,"doc-seo-451062-105":81},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":72,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":73,"language":74,"language_code":75,"site_id":76,"html_lang":75,"table_of_contents":77,"faqs":78,"seo_title":79,"seo_description":66,"update_tm":80,"read_time":36,"preview_page_count":4},451062,962085571259,"Putri","https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Novel multifunctional composite cryogel with high-performance and rapid fat-lowering efficacy via the synergy of fat digestion blockage and synthesis inhibition - Abstract","Excessive dietary fat intake raises health risks, prompting interest in biomaterials that adsorb fat while blocking digestion to improve anti-obesity performance. Cryogels are typically not used as dual-function fat-blocking systems. This work reports an oral hydrophobic composite cryogel releasing curcumin, assembled from cellulose nanofiber and carrageenan, engineered by process optimization to enhance microstructure and adsorption. Simulated digestion and high-fat diet studies show strong fat/oil absorption, reduced fat hydrolysis, lower body weight, altered fecal fat and inflammation markers, and gut microbiota modulation without toxicity, supporting potential obesity management.","Bioactive Materials 58 (2026) 574–589  \nContents lists available at ScienceDirect  \nBioactive Materials  \njournal [homepage:](homepage: www.keaipublishing.com/en/journals/bioactive-materials)[ www.keaipublishing.com/en/journals/bioactive-materials](homepage: www.keaipublishing.com/en/journals/bioactive-materials)  \n| Novel multifunctional composite cryogel with high-performance and rapid   fat-lowering efficacy via the synergy of fat digestion blockage and\u003Cbr>synthesis inhibition\u003Cbr>Hongyun Lua, Yejiayi Lva, Siyu Liu a, Peng Xuc, Ying Shia, Qihe Chena,b,* \u003Cbr>a Department of Food Science and Nutrition, Zhejiang University, Hangzhou, 310058, China\u003Cbr>b Future Food Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, Zhejiang, 314100, China\u003Cbr>c Institute for Composites Science Innovation, School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China |  |  |\n| --- | --- | --- |\n| A R T I C L E I N F O |  | A B S T R A C T |\n| Keywords: Nanocellulose Hydrophobic cryogels Fat/oil absorption Fat digestion inhibitors\u003Cbr>Fat synthesis |  | Excessive dietary fat intake poses considerable health risks. Developing biomaterials with fat adsorption and digestion intervention properties may satisfy consumer preferences for fat taste while enhancing anti-obesity efficacy. However, this strategy has remained largely unrealized. Cryogels, known for exceptional wettability and porous structure, are not employed as fat-blocking biomaterials with dual functionality. Herein, a novel curcumin (Cur)-releasing hydrophobic oral composite cryogel with excellent fat ingestion inhibition was fabricated using cellulose nanofiber (CNF) and carrageenan (Car). By optimizing the preparation process, the microstructure, porosity, and adsorption properties were analyzed to improve performance and functionality. Subsequently, the lipophilic performance and fat-lowering effect of the cryogel were further investigated through simulated gastrointestinal digestion and high-fat diet models. The proposed oral cryogels, with 91.10–98.70 % porosity and 145◦ hydrophobic angle, displayed favorable porous structure and fat/oil absorption capacity. Incorporation of Car-CNF-Cur cryogel reduced stimulated fat hydrolysis by 23.4 %. Additionally, supplementation with Car-CNF-Cur cryogels in high-fat diet significantly lowered body weight and fat synthetase expression in mice after short-term ingestion. This treatment also increased fecal fat content by 29.45 %, suppressed inflammation and lipopolysaccharide without toxicity, along with modulated gut microbiota composition, thereby interfering with fat digestion. Collectively, these findings highlight the potential of Car-CNF-Cur cryogels as a promising oral fat-lowering biomaterial for obesity management. |\n\n1. Introduction  \nThe global prevalence of obesity has risen substantially, largely driven by the excessive consumption of high-calorie fatty foods [1]. Despite growing awareness of the health risks associated with high dietary fat, the palatability and appeal of fatty foods continue to fuel cravings and overconsumption. Therefore, balancing satiety with reducing metabolic stress induced by fat consumption remains a critical challenge. In this context, effective and safe strategies to limit fat absorption show promise in reducing calorie intake and enhancing weight management efficacy. Fat adsorbents based on physical barriers and digestive obstruction hold considerable potential for inhibiting fat metabolism. By adsorbing ingested fats, they can reduce caloric intake  \nand optimize lipid metabolism pathways in the liver [2], providing an innovative approach to weight management and blood fat regulation. Presently, cellulose has gained considerable attention for its ability to hinder the digestion and absorption of dietary fats [3,4]. However, cellulose faces limitations, including breakdown in water, poor stability, and oil desorption, which restrict its practical","cbCaifkukcxPKiDz","https://ap.wps.com/l/cbCaifkukcxPKiDz","pdf",18410936,13,16,"English","en",105,"# Introduction\n## Background and problem statement\n## Limitations of existing cellulose-based approaches\n## Inspiration from natural porous structures and hydrophobic polymers\n## Rationale and goals of the study","[{\"question\":\"What problem does the study address regarding dietary fat?\",\"answer\":\"Excessive high-calorie fat intake increases health risks and can contribute to obesity. The work targets the challenge of reducing fat absorption while maintaining acceptable food-related fat palatability.\"},{\"question\":\"How is the cryogel designed in this research?\",\"answer\":\"A curcumin-releasing hydrophobic oral composite cryogel is fabricated using cellulose nanofiber and carrageenan. Preparation conditions are optimized to improve microstructure, porosity, and adsorption properties.\"},{\"question\":\"What effects does the cryogel show in digestion and animal models?\",\"answer\":\"The cryogel demonstrates strong fat ingestion inhibition in simulated gastrointestinal digestion and lowers body weight and fat-synthesis-related expression in mice on a high-fat diet, alongside increased fecal fat content and suppressed inflammation markers without toxicity.\"}]","Novel multifunctional composite cryogel with high-performance and rapid fat-lowering efficacy via the synergy of fat digestion blockage and synthesis inhibition - Abstract | PDF",1790734303,{"code":4,"msg":82,"data":83},"ok",{"site_id":76,"language":75,"slug":84,"title":65,"keywords":85,"description":66,"schema_data":86,"social_meta":140,"head_meta":142,"extra_data":144,"updated_unix":145},"novel-multifunctional-composite-cryogel-with-high-performance-and-rapid-fat-lowering-efficacy-via-the-synergy-of-fat-digestion-blockage-and-synthesis-inhibition-abstract","",{"@graph":87,"@context":139},[88,102,122],{"@type":89,"itemListElement":90},"BreadcrumbList",[91,95,97,100],{"item":92,"name":93,"@type":94,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":96,"name":9,"@type":94,"position":14},"https://docshare.wps.com/document/",{"item":98,"name":35,"@type":94,"position":99},"https://docshare.wps.com/document/healthcare/",3,{"item":101,"name":65,"@type":94,"position":19},"https://docshare.wps.com/document/novel-multifunctional-composite-cryogel-with-high-performance-and-rapid-fat-lowering-efficacy-via-the-synergy-of-fat-digestion-blockage-and-synthesis-inhibition-abstract/451062/",{"url":101,"name":65,"@type":103,"image":104,"author":109,"headline":65,"publisher":111,"fileFormat":114,"inLanguage":75,"description":66,"dateModified":115,"datePublished":116,"encodingFormat":114,"isAccessibleForFree":117,"interactionStatistic":118},"DigitalDocument",{"url":105,"@type":106,"width":107,"height":108},"https://docshare.wps.com/thumbnails/novel-multifunctional-composite-cryogel-with-high-performance-and-rapid-fat-lowering-efficacy-via-the-synergy-of-fat-digestion-blockage-and-synthesis-inhibition-abstract/451062.png","ImageObject",300,407,{"name":63,"@type":110},"Person",{"url":92,"name":112,"@type":113},"DocShare","Organization","application/pdf","2026-11-03","2026-09-30",true,{"@type":119,"interactionType":120,"userInteractionCount":72},"InteractionCounter",{"@type":121},"ViewAction",{"@type":123,"mainEntity":124},"FAQPage",[125,131,135],{"name":126,"@type":127,"acceptedAnswer":128},"What problem does the study address regarding dietary fat?","Question",{"text":129,"@type":130},"Excessive high-calorie fat intake increases health risks and can contribute to obesity. The work targets the challenge of reducing fat absorption while maintaining acceptable food-related fat palatability.","Answer",{"name":132,"@type":127,"acceptedAnswer":133},"How is the cryogel designed in this research?",{"text":134,"@type":130},"A curcumin-releasing hydrophobic oral composite cryogel is fabricated using cellulose nanofiber and carrageenan. Preparation conditions are optimized to improve microstructure, porosity, and adsorption properties.",{"name":136,"@type":127,"acceptedAnswer":137},"What effects does the cryogel show in digestion and animal models?",{"text":138,"@type":130},"The cryogel demonstrates strong fat ingestion inhibition in simulated gastrointestinal digestion and lowers body weight and fat-synthesis-related expression in mice on a high-fat diet, alongside increased fecal fat content and suppressed inflammation markers without toxicity.","https://schema.org",{"og:url":101,"og:type":141,"og:title":65,"og:site_name":112,"og:description":66},"article",{"robots":143,"canonical":101},"index,follow",{"doc_id":61,"site_id":76},1790764106]