[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-342721-105":3,"detail-sidebar-cat-0-en-105":80,"doc-detail-342721-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","novel-milestones-for-early-esophageal-carcinoma-from-bench-to-bed","Novel milestones for early esophageal carcinoma - From bench to bed","","Esophageal cancer (EC) ranks among the most common cancers globally, with esophageal squamous cell carcinoma (ESCC) comprising the majority of EC cases. Early, timely diagnosis is essential to enable effective detection and treatment, ultimately improving patient prognosis. This review synthesizes recent advances and emerging technologies for early EC identification, integrating molecular biology and epigenetics methods with fluorescence qPCR, high-throughput sequencing, and digital PCR. It also highlights microbiome research, endoscopic innovations, and increasing AI-driven assistance for detection, invasion depth prediction, and more accurate ESCC diagnosis.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/novel-milestones-for-early-esophageal-carcinoma-from-bench-to-bed/342721/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/novel-milestones-for-early-esophageal-carcinoma-from-bench-to-bed/342721.png","ImageObject",300,407,{"name":42,"@type":43},"Emma Wilson","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":26},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"Why is timely early diagnosis important for ESCC?","Question",{"text":62,"@type":63},"Early identification supports effective diagnosis and treatment planning and is crucial for improving prognosis and the chance of curative surgical resection.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"Which molecular and epigenetic approaches are used for early EC detection in this review?",{"text":67,"@type":63},"The review describes using molecular biology and epigenetics strategies with fluorescence quantitative PCR (qPCR), high-throughput sequencing (next-generation sequencing), and digital PCR to study biomolecular changes.",{"name":69,"@type":60,"acceptedAnswer":70},"How does endoscopy and artificial intelligence improve early ESCC detection?",{"text":71,"@type":63},"Endoscopy is a key technique for early identification and has been continuously improved. AI can reduce observer discrepancies, increase detection rates, help predict invasion depth and differentiation status, and support more accurate diagnosis, including guidance for pericancerous margins.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},342721,1790136139,{"code":4,"msg":81,"data":82},"success",[83,87,91,95,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":84,"show_sort_weight":85,"slug":86},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":88,"show_sort_weight":89,"slug":90},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":92,"show_sort_weight":93,"slug":94},"Exam",70,"exam",{"id":96,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},5,"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":96,"slug":129},19,"General","general",{"code":4,"msg":81,"data":131},{"doc_id":78,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":26,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":107},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","| W | J | G | O | World Journal of\u003Cbr>Gastrointestinal Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2024 April 15; 16(4): 1104-1118  \nDOI: 10.4251/wjgo.v16.i4.1104 ISSN 1948-5204 (online)  \nREVIEW  \nNovel milestones for early esophageal carcinoma: From bench to bed  \nJi-Han Qi, Shi-Ling Huang, Shi-Zhu Jin  \nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s scientific quality classification  \nGrade A (Excellent): 0  \nGrade B (Very good): 0  \nGrade C (Good): C  \nGrade D (Fair): 0  \nGrade E (Poor): 0  \nP-Reviewer: Habu T, Japan  \nReceived: December 15, 2023  \nPeer-review started: December 15, 2023  \nFirst decision: January 15, 2024  \nRevised: January 28, 2024  \nAccepted: February 26, 2024  \nArticle in press: February 26, 2024  \nPublished online: April 15, 2024  \nJi-Han Qi, Shi-Ling Huang, Shi-Zhu Jin, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang Province, China  \nCorresponding author: Shi-Zhu Jin, MD, PhD, Chief Physician, Professor, Department of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, No. 246 XueFu Road, Nangang District, Harbin 150086, Heilongjiang Province, [China.](China. drshizhujin@hrbmu.edu.cn)[ drshizhujin@hrbmu.edu.cn](China. drshizhujin@hrbmu.edu.cn)  \nAbstract  \nEsophageal cancer (EC) is the seventh most common cancer worldwide, and esophageal squamous cell carcinoma (ESCC) accounts for the majority of cases of EC. To effectively diagnose and treat ESCC and improve patient prognosis, timely diagnosis in the initial phase of the illness is necessary. This article offers a detailed summary of the latest advancements and emerging technologies in the timely identification of ECs. Molecular biology and epigenetics approaches involve the use of molecular mechanisms combined with fluorescence quantitative polymerase chain reaction (qPCR), high-throughput sequencing technology (next-generation sequencing), and digital PCR technology to study endogenous or exogenous biomolecular changes in the human body and provide a decisionmaking basis for the diagnosis, treatment, and prognosis of diseases. The investigation of the microbiome is a swiftly progressing area in human cancer research, and microorganisms with complex functions are potential components of the tumor microenvironment. The intratumoral microbiota was also found to be connected to tumor progression. The application of endoscopy as a crucial technique for the early identification of ESCC has been essential, and with ongoing advancements in technology, endoscopy has continuously improved. With the advancement of artificial intelligence (AI) technology, the utilization of AI in the detection of gastrointestinal tumors has become increasingly prevalent. The implementation of AI can effectively resolve the discrepancies among observers, improve the detection rate, assist in predicting the depth of invasion and differentiation status, guide the pericancerous margins, and aid in a more accurate diagnosis of ESCC.  \nKey Words: Early esophageal squamous cell carcinoma; Epidemiology and risk factors; Molecular biology; Epigenetic; Microbiology; Endoscopy and artificial intelligence  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 1104 April 15, 2024  Volume 16  Issue 4   \nQi JH et al. Novel milestones for early esophageal carcinoma  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: The incidence of esophageal cancer is high worldwide, with and esophageal squamous cell carcinoma (ESCC) is the predominant histological subtype. With in-depth research and the development of technology, various methods have been employed to promptly identify earl","cbCaiv5naSP0C685","https://ap.wps.com/l/cbCaiv5naSP0C685","pdf",4836491,16,"English","# Abstract\n# Core Tip\n# Background and Clinical Need\n# Etiology, Risk Factors, and Early Diagnosis","[{\"question\":\"Why is timely early diagnosis important for ESCC?\",\"answer\":\"Early identification supports effective diagnosis and treatment planning and is crucial for improving prognosis and the chance of curative surgical resection.\"},{\"question\":\"Which molecular and epigenetic approaches are used for early EC detection in this review?\",\"answer\":\"The review describes using molecular biology and epigenetics strategies with fluorescence quantitative PCR (qPCR), high-throughput sequencing (next-generation sequencing), and digital PCR to study biomolecular changes.\"},{\"question\":\"How does endoscopy and artificial intelligence improve early ESCC detection?\",\"answer\":\"Endoscopy is a key technique for early identification and has been continuously improved. AI can reduce observer discrepancies, increase detection rates, help predict invasion depth and differentiation status, and support more accurate diagnosis, including guidance for pericancerous margins.\"}]","Novel milestones for early esophageal carcinoma - From bench to bed | PDF",1790047867]