[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-407821-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-407821-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","novel-markers-of-myocardial-recovery-in-patients-with-left-ventricular-assist-device-a-cardiopulmonary-exercise-test-and-hemodynamic-analysis","Novel markers of myocardial recovery in patients with left ventricular assist device - A cardiopulmonary exercise test and hemodynamic analysis","","Left ventricular assist device (LVAD)-associated myocardial recovery is achievable in some advanced heart failure patients. Beyond peak oxygen consumption (pVO2), the study evaluates cardiopulmonary exercise testing (CPET) metrics—especially post-exercise oxygen uptake recovery delay (VO2RD) and ventilatory efficiency (VE/VCO2 slope)—and invasive hemodynamic pressure-flow slopes to characterize recovery. A retrospective cohort of LVAD recipients links lower VO2RD thresholds and reduced pressure-flow slopes with complete recovery, suggesting integration into a prospective weaning approach for myocardial recovery assessment.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/novel-markers-of-myocardial-recovery-in-patients-with-left-ventricular-assist-device-a-cardiopulmonary-exercise-test-and-hemodynamic-analysis/407821/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/novel-markers-of-myocardial-recovery-in-patients-with-left-ventricular-assist-device-a-cardiopulmonary-exercise-test-and-hemodynamic-analysis/407821.png","ImageObject",300,407,{"name":42,"@type":43},"Cart","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is VO2RD and why is it relevant for LVAD recovery assessment?","Question",{"text":63,"@type":64},"VO2RD is the time for VO2 to fall permanently below peak levels after exercise ends. In heart failure, prolonged VO2RD indicates impaired cardiac output response, and this study evaluates its role in LVAD-associated myocardial recovery.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were recovery groups defined in the study?",{"text":68,"@type":64},"The analysis included 46 LVAD recipients with CPET, with 5 patients achieving complete recovery and LVAD explant (recovered group). A subset also underwent invasive hemodynamics during CPET.",{"name":70,"@type":61,"acceptedAnswer":71},"Which additional measures were used besides pVO2 to assess recovery?",{"text":72,"@type":64},"The study used CPET-derived VO2RD thresholds, VE/VCO2 slope components across exercise phases, and invasive pressure-flow slopes derived from PAWP and PAP against cardiac output (CO) during exercise.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},407821,1790962351,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":115,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},18829141979164,"https://eur-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","[https://www.jhltopen.org/](https://www.jhltopen.org/)  \nNovel markers of myocardial recovery in patients with left ventricular assist device: A cardiopulmonary exercise test and hemodynamic analysis  \nCharounipha Soydara, NP-C,a, b Ilya Giverts, MD,a, c  \nCatharine L. Griskowitz, BS,a Isabela Landsteiner, MD,a Kamila Drezek, BS,d Alexandra Minasian, MS,a Tara L. Logan, BSN,d Janice Camuso, BSN,d Alexandra E. Dempsey, BSN,d Katherine Milley, NP, MSN,d  \nAsishana A. Osho, MD, MPH,d Eriberto Michel, MD,d Erin Coglianese, MD,a Ioannis Mastoris, MD,a David A. D’Alessandro, MD,d  \nCorrine Y. Jurgens, PhD, RN, FHFSA,b Gregory D. Lewis, MD,a and Van-Khue Ton, MD, PhDa,⁎  \naThe Mass General Brigham Heart and Vascular Institute, Massachusetts General Hospital, Boston, Massachusetts  \nbWilliam F. Connell School of Nursing, Boston College, Chestnut Hill, Massachusetts cDepartment of Internal Medicine, Maimonides Medical Center, Brooklyn, New York dDepartment of Cardiac Surgery, Massachusetts General Hospital, Boston, Massachusetts  \nKEYWORDS:  \nLVAD;  \nCPET;  \nexercise recovery delay;  \npressure-flow slopes; myocardial recovery  \nBACKGROUND: Left ventricular assist device (LVAD)-associated myocardial recovery is possible. Beyond peak O2 consumption (pVO2), parameters obtained from cardiopulmonary exercise testing (CPET), such as post exercise oxygen uptake recovery delay (VO2RD), ventilatory efficiency (VE/ VCO2 slope), and pressure-flow slopes from invasive hemodynamics, may offer novel insights in recovery assessment.  \nMETHODS: We performed a retrospective analysis of 46 LVAD recipients with CPET (2014-2024), of whom 5 had complete recovery and LVAD explant (recovered group) . A subset (n = 23) had invasive hemodynamics during CPET. VO2RD thresholds were defined as the time required for VO2 to fall below 12.5%, 25%, and 50% of pVO2 (T 12.5%, T25%, T50%) . Pressure-flow slopes were derived by regressing pulmonary artery wedge pressure (PAWP) and mean pulmonary artery pressure (PAP) against cardiac output (CO) throughout exercise.  \nRESULTS: Compared to nonrecovered group, recovered patients had higher left ventricular ejection fraction (47%[45-48] vs 19%[16-28], p = 0.001), higher pVO2 (14.0 [13.6-20.6] vs 11.0 [9.9-12.3] ml/kg/min, p = 0.007), shorter VO2RD thresholds (T12.5% : 31.4 ± 11.7 vs 47.7 ± 19.1 s, p = 0.03; T25% : 46.8 ± 7.1 vs 65.3 ± 25 s, p = 0.0038; T50% : 82 ± 10.1 vs 99.6 ± 20.9 s, p = 0.027), lower PAWP/CO  \n⁎Corresponding author: Van-Khue Ton, MD, PhD, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114.  \nE-mail address: [kton@mgb.org](kton@mgb.org).  \n2950-1334/© 2025 The Authors. Published by Elsevier Inc. on behalf of International Society for Heart and Lung Transplantation. This is an open access article under the CC BY license ([http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/)).  \n[https://doi.org/10.1016/j.jhlto.2025.100444](https://doi.org/10.1016/j.jhlto.2025.100444)  \n(1.1 vs 3.6 mm Hg/liter/min, p = 0.003) and PAP/CO (2.4 vs 4.3 mm Hg/liter/min, p = 0.03) slopes. VE/VCO2 slope components in all exercise phases were similar.  \nCONCLUSIONS: VO2RD and pressure-flow slopes were lower in recovered patients, and could be incorporated into a prospective wean protocol assessing for complete myocardial recovery in LVADsupported patients.  \nJHLT Open 2026;11:100444  \n© 2025 The Authors. Published by Elsevier Inc. on behalf of International Society for Heart and Lung Transplantation. This is an open access article under the CC BY license ([http://creativecommons.org/](http://creativecommons.org/)[ ](http://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \nBackground  \nDurable left ventricular assist device (LVAD) promotes complete myocardial recovery in some patients with advanced heart failure (HF), allowing for successful weaning from LVAD support.1 Existing studies proposed echocardiographic and hemodynamic criteria at rest for LVAD weaning protoco","cbCaisxnBVKvyNLA","https://ap.wps.com/l/cbCaisxnBVKvyNLA","pdf",3761340,"English","# Background\n# Methods\n# Results\n# Conclusions\n# Background (expanded)","[{\"question\":\"What is VO2RD and why is it relevant for LVAD recovery assessment?\",\"answer\":\"VO2RD is the time for VO2 to fall permanently below peak levels after exercise ends. In heart failure, prolonged VO2RD indicates impaired cardiac output response, and this study evaluates its role in LVAD-associated myocardial recovery.\"},{\"question\":\"How were recovery groups defined in the study?\",\"answer\":\"The analysis included 46 LVAD recipients with CPET, with 5 patients achieving complete recovery and LVAD explant (recovered group). A subset also underwent invasive hemodynamics during CPET.\"},{\"question\":\"Which additional measures were used besides pVO2 to assess recovery?\",\"answer\":\"The study used CPET-derived VO2RD thresholds, VE/VCO2 slope components across exercise phases, and invasive pressure-flow slopes derived from PAWP and PAP against cardiac output (CO) during exercise.\"}]","Novel markers of myocardial recovery in patients with left ventricular assist device - A cardiopulmonary exercise test and hemodynamic analysis | PDF",1790576280,23]