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Prior work showed AL137782.1, a novel lncRNA transcript, is upregulated in lung epithelial cells after microbial exposure and varies between para-cancerous and lung adenocarcinoma samples. Bioinformatics and expression analyses were combined with FISH, subcellular fractionation, and RACE to confirm a 4401-nt transcript. AL137782.1 positively regulates LMO7 mRNA and protein, enhancing migration in vitro; its expression decreases in lung cancers versus adjacent tissue, suggesting the AL137782.1–LMO7 axis mainly supports normal lung epithelial cell migration and may aid repair after lung injury.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/novel-long-non-coding-rna-lncrna-transcript-al1377821-promotes-the-migration-of-normal-lung-epithelial-cells-through-positively-regulating-lmo7/377250/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/novel-long-non-coding-rna-lncrna-transcript-al1377821-promotes-the-migration-of-normal-lung-epithelial-cells-through-positively-regulating-lmo7/377250.png","ImageObject",300,407,{"name":92,"@type":93},"McQueen","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biological role does AL137782.1 suggest in lung epithelial cells?","Question",{"text":112,"@type":113},"AL137782.1 appears to participate in normal lung epithelial cell processes and helps regulate cell migration by positively controlling LMO7 expression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the study confirm the presence of AL137782.1 in lung epithelial cells?",{"text":117,"@type":113},"The researchers used bioinformatics expression analysis, fluorescence in situ hybridization (FISH), subcellular fractionation, and rapid amplification of cDNA ends (RACE) to confirm the 4401-nt transcript.",{"name":119,"@type":110,"acceptedAnswer":120},"Does AL137782.1 promote migration mainly in normal cells or in lung cancer cells?",{"text":121,"@type":113},"The study indicates the migration pattern driven by the AL137782.1–LMO7 axis is more likely characteristic of normal lung epithelial cells, because AL137782.1 expression is significantly reduced in lung cancer compared with adjacent tissues.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},377250,1790733033,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},5909890329169,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Article  \nNovel Long Non-Coding RNA (lncRNA) Transcript AL137782.1 Promotes the Migration of Normal Lung Epithelial Cells through Positively Regulating LMO7  \nYing Zhang 1,2, Weili Wang 1,2, Chunchun Duan 1,2, Min Li 1,2,* and Liyang Gao 1,2, *  \nCitation: Zhang, Y.; Wang, W.; Duan, C.; Li, M.; Gao, L. Novel Long  \nNon-Coding RNA (lncRNA) Transcript AL137782.1 Promotes the Migration of Normal Lung Epithelial Cells through Positively Regulating LMO7 . Int. J. Mol. Sci. 2023, 24, 13904 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms241813904  \nAcademic Editor: Erik A.C. Wiemer  \nReceived: 7 August 2023  \nRevised: 4 September 2023  \nAccepted: 6 September 2023  \nPublished: 9 September 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Life Science School, Ningxia University, Yinchuan 750001, China; [zhangying191231@126.com](zhangying191231@126.com) (Y.Z.); [w15709104535@163.com](w15709104535@163.com) (W.W.); [d18793811649@aliyun.com](d18793811649@aliyun.com) (C.D.)  \n2 Key Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in the Western, Ningxia University, Yinchuan 750001, China  \n* Correspondence: [lim@nxu.edu.cn](lim@nxu.edu.cn) (M.L.); [pandarun@nxu.edu.cn](pandarun@nxu.edu.cn) (L.G.)  \nAbstract: The role of long non-coding RNA (lncRNAs) in biological processes remains poorly understood, despite their significant impact. Our previous research discovered that the expression of AL137782.1, a long transcript of the novel lncRNA ENSG00000261553, is upregulated in lung epithelial cells upon exposure to microbes. Furthermore, the expression of AL137782.1 exhibits variability between para-cancerous and lung adenocarcinoma samples. These findings imply that this lncRNA may play a role in both normal lung epithelial cellular processes and pathophysiology. To elucidate the function of AL137782.1 in lung epithelial cells, we utilized bioinformatics retrieval and analysis to examine its expression. We then analyzed its subcellular localization using fluorescence in situ hybridization (FISH) and subcellular fractionation. Through rapid amplification of cDNA ends (RACE), we confirmed the presence of a 4401 nt lncRNA AL137782.1 in lung epithelial cells. Moreover, we discovered that this lncRNA positively regulates both mRNA and the protein expression of LMO7, a protein that may regulate the cell migration of normal lung epithelial cells. Although the overexpression of AL137782.1 has been shown to enhance the migration of both normal lung epithelial cells and lung adenocarcinoma cells in vitro, our study revealed that the expression of this lncRNA was significantly decreased in lung cancers compared to adjacent tissues. This suggests that the cell migration pattern regulated by the AL137782.1–LMO7 axis is more likely to occur in normal lung epithelial cells, rather than being a pathway that promotes lung cancer cell migration. Therefore, our study provides new insights into the mechanism underlying cell migration in human lung epithelial cells. This finding may offer a potential strategy to enhance normal lung epithelial cell migration after lung injury.  \nKeywords: lncRNA AL137782.1; lung epithelial cells; cell migration; LMO7  \n1. Introduction  \nThe lung epithelium is a crucial physical barrier that protects the lung from environmental aggressors, stabilizing lung function and resisting invasion by foreign pathogens [1] . It consists of bronchial and alveolar epithelial cells, as well as pulmonary endothelial cells, which together form a complex internal structure [2] . Bronchial epithelial cells play an essential role in airway defense by provid","cbCaile1iCp0CcH4","https://ap.wps.com/l/cbCaile1iCp0CcH4","pdf",8661358,16,"English","# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"What biological role does AL137782.1 suggest in lung epithelial cells?\",\"answer\":\"AL137782.1 appears to participate in normal lung epithelial cell processes and helps regulate cell migration by positively controlling LMO7 expression.\"},{\"question\":\"How did the study confirm the presence of AL137782.1 in lung epithelial cells?\",\"answer\":\"The researchers used bioinformatics expression analysis, fluorescence in situ hybridization (FISH), subcellular fractionation, and rapid amplification of cDNA ends (RACE) to confirm the 4401-nt transcript.\"},{\"question\":\"Does AL137782.1 promote migration mainly in normal cells or in lung cancer cells?\",\"answer\":\"The study indicates the migration pattern driven by the AL137782.1–LMO7 axis is more likely characteristic of normal lung epithelial cells, because AL137782.1 expression is significantly reduced in lung cancer compared with adjacent tissues.\"}]","Novel Long Non-Coding RNA (lncRNA) Transcript AL137782.1 Promotes the Migration of Normal Lung Epithelial Cells through Positively Regulating LMO7 | PDF",1790223942]