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It emphasizes HIF-1α/SLC16A8 activation increasing glycolytic flux and lactate production, while SLC16A8 also promotes lactate transport linked to endothelial-mesenchymal transition. 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|\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastrointest Oncol 2025 December 15; 17(12): 112894  \nDOI: 10.4251/wjgo.v17.i12.112894 ISSN 1948-5204 (online)  \nLETTER TO THE EDITOR  \nNovel insights into SLC16A8 in colorectal cancer  \nJing-Yuan Li, Guang Ji, Yan-Qi Dang  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade B  \nNovelty: Grade B, Grade B  \nCreativity or Innovation: Grade B, Grade B  \nScientific Significance: Grade B, Grade B  \nP-Reviewer: El-Baz AM, PhD, Associate Professor, Egypt; Zheng YY, Associate Professor, Associate Research Scientist, China  \nReceived: August 8, 2025  \nRevised: September 12, 2025  \nAccepted: October 23, 2025  \nPublished online: December 15, 2025  \nProcessing time: 125 Days and 5.5 Hours  \nJing-Yuan Li, Guang Ji, Yan-Qi Dang, Institute of Digestive Diseases, Longhua Hospital, ChinaCanada Center of Research for Digestive Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China  \nCorresponding author: Yan-Qi Dang, PhD, Institute of Digestive Diseases, Longhua Hospital, China-Canada Center of Research for Digestive Diseases, Shanghai University of Traditional Chinese Medicine, Fenglin Road Sub-district, Shanghai 200032, China.  \n[dangyanqi9022@126.com](dangyanqi9022@126.com)  \nAbstract  \nColorectal cancer (CRC) ranks as the third most prevalent cancer globally, and hypoxia-induced metabolic reprogramming is considered a key driver of its malignant progression. We read with interest the article by Tian et al, which examines the role of solute carrier family 16 member 8 (SLC16A8) in regulating the tumor microenvironment. The study provides valuable evidence supporting the dual mechanisms by which SLC16A8 influences CRC pathogenesis and offers new directions for clinical research. This work demonstrates that activation of the HIF-1α/SLC16A8 axis under hypoxic conditions enhances glycolytic flux and lactate production. Additionally, SLC16A8 facilitates lactate transport, thereby inducing endothelial-mesenchymal transition—a finding that underscores its functional significance in shaping the tumor microenvironment. We believe the mechanistic insights presented in this study contribute meaningfully to the understanding of CRC biology. We would like to share our interpretations and hope to further discuss with the authors certain unexplored aspects and potential connections in this area.  \nKey Words: Solute carrier family 16 member 8; Colorectal cancer; Hypoxic; Glycolysis; Tumor microenvironment; Endothelium-mesenchymal transition; siRNA; Genes; Biomarker; Cancer  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Solute carrier family 16 member 8 (SLC16A8) drives the progression of the hypoxic microenvironment in colorectal cancer through dual mechanisms: Glycolytic reprogramming mediated by HIF-1α and endothelium-mesenchymal transition. Targeting SLC16A8 synergistically inhibits metabolic adaptation and vascular remodeling, demonstrating potential for clinical translation.  \n WJGO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 15, 2025  Volume 17  Issue 12   \nLi JY et al. Novel insights into SLC16A8 in CRC  \nCitation: Li JY, Ji G, Dang YQ. Novel insights into SLC16A8 in colorectal cancer. World J Gastrointest Oncol 2025; 17(12): 112894  \nURL: [https://www.wjgnet.com/1948-5204/full/v17/i12/112894.htm](https://www.wjgnet.com/1948-5204/full/v17/i12/112894.htm)  \nDOI: [https://dx.doi.org/10.4251/wjgo.v17.i12.112894](https://dx.doi.org/10.4251/wjgo.v17.i12.112894)  \nThis study provides an important theoretical breakthrough and potential therapeutic target for colorectal cancer (CRC) The research team used a systemat","cbCaibbiSkJAYRjJ","https://ap.wps.com/l/cbCaibbiSkJAYRjJ","pdf",354020,"English","# Letter to the Editor\n## Novel insights into SLC16A8 in colorectal cancer\n## Abstract\n## Key Words\n## Core Tip","[{\"question\":\"What is SLC16A8 proposed to do in colorectal cancer under hypoxic conditions?\",\"answer\":\"The text states that activation of the HIF-1α/SLC16A8 axis under hypoxia enhances glycolytic flux and lactate production, and also facilitates lactate transport.\"},{\"question\":\"How does SLC16A8 relate to the tumor microenvironment?\",\"answer\":\"The letter explains that SLC16A8-associated lactate transport can induce endothelial-mesenchymal transition, supporting functional significance in shaping the tumor microenvironment.\"},{\"question\":\"Why are the authors interested in the study by Tian et al?\",\"answer\":\"They describe it as providing mechanistic insights and valuable evidence supporting dual mechanisms, and they express hope to further discuss additional unexplored aspects and connections with the authors.\"}]","Novel insights into SLC16A8 in colorectal cancer - Letter to the Editor | PDF",1790566240]