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Because DS-associated AD follows a predictable, accelerated course, it offers a precise window into early amyloid and tau pathology, neuroinflammation, cerebrovascular pathology, and neurodegeneration. Recent international cohorts and targeted funding have advanced longitudinal, multimodal research and position DSAD for prevention and disease-modifying therapy testing.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/novel-insights-into-alzheimers-disease-through-the-study-of-individuals-with-down-syndrome-editorial/457871/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/novel-insights-into-alzheimers-disease-through-the-study-of-individuals-with-down-syndrome-editorial/457871.png","ImageObject",300,407,{"name":92,"@type":93},"dawugda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is Alzheimer’s disease research in Down syndrome considered uniquely valuable?","Question",{"text":113,"@type":114},"DS provides a predictable, accelerated pathway to AD neuropathology, enabling study of molecular and cellular origins long before symptoms emerge.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which research efforts are highlighted as reshaping DS-associated AD studies?",{"text":118,"@type":114},"Large international initiatives are described, including the Alzheimer’s Biomarker Consortium–Down Syndrome (ABC-DS), DABNI, Horizon 21, and TRC-DS, along with increased NIH/NIA support via the INCLUDE project.",{"name":120,"@type":111,"acceptedAnswer":121},"What kinds of data do the DS-associated AD cohorts provide?",{"text":122,"@type":114},"The cohorts generate longitudinal, multimodal information spanning clinical, cognitive, fluid, imaging, and genetic measures for harmonized comparisons.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},457871,1790811775,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":81,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":39,"preview_page_count":4},3985747870947,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","DOI: 10.1002/alz.71074  \nEDITORIAL  \nNovel insights into Alzheimer’s disease through the study of individuals with Down syndrome  \nPeople with Down syndrome (DS) represent the largest genetically defined population at risk for Alzheimer’s disease (AD).1 Virtually all adults with DS develop AD neuropathology by midlife due to triplication of the amyloid precursor protein (APP) gene on chromosome 21. As medical advances and social integration have extended life expectancy into the 60s, AD has emerged as the major determinant of cognitive decline, morbidity, and mortality in this DS population.2  \nWhat was once viewed as an inevitable consequence of aging in DS is now recognized as a unique scientific opportunity to uncover the earliest events that drive AD. The predictable and accelerated course of DS-associated AD (DSAD) provides an unparalleled window into the molecular and cellular origins of amyloid and tau pathology, neuroinflammation, cerebrovascular pathology, and neurodegeneration. It allows us to study, with precision, the sequence of pathological changes long before symptoms emerge. This is knowledge that benefits not only individuals with DS but also the broader AD community seeking to prevent disease before it begins.  \nThe past decade has witnessed a transformation in DSAD research, driven by unprecedented collaboration, infrastructure, and investment. Large-scale international initiatives such as the Alzheimer’s Biomarker Consortium–Down Syndrome (ABC-DS),3,4 the Down Alzheimer Barcelona Neuroimaging Initiative (DABNI),5 the Horizon 21 Consortium ([https://horizon-21.org/](https://horizon-21.org/))6 and the Trial Ready Cohort– Down Syndrome (TRC-DS) ([https://www.trcds.org/](https://www.trcds.org/)) are reshaping our understanding of the natural history of AD in DS. Together, these cohorts provide longitudinal, multimodal data encompassing clinical, cognitive, fluid, imaging, and genetic measures, allowing harmonized comparisons across continents and with sporadic and autosomal dominant forms of AD.  \nEqually important has been the extraordinary increase in research investment, particularly through the National Institutes of Health (NIH) and its National Institute on Aging (NIA), catalyzed by the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project ([https://www.nih.gov/](https://www.nih.gov/)[ ](https://www.nih.gov/)[include-project](include-project)). This strategic funding initiative has enabled infrastructure for multi-site studies, data sharing, and advanced biomarker development, while also fostering the training and expansion of anew generation of DSAD investigators. The impact has been dra-  \nmatic, reflected in an exponential rise in peer-reviewed publicationson DSAD over the past decade (Figure 1). The field has matured from a niche interest to a globally connected research network producing high-quality, high-impact science. The consistency of amyloid overproduction in DS and the predictable onset of pathology make DSAD uniquely suited to testing preventive and disease-modifying therapies.  \nThis special issue of Alzheimer’s & Dementia showcases the breadth and maturity of this field, from molecular mechanisms to clinical and societal perspectives, and highlights the essential role of inclusion and partnership. One particularly important contribution comes from a self-advocate with Down syndrome, who reminds us that meaningful progress requires inclusive research with and not just about people with DS.  \nThis special issue encouraged submission of articles from all researchers focused on aging and AD in people with DS. We were delighted to receive manuscripts reflecting a broad range of perspectives and topics (Figure 2) from researchers around the world with novel and innovative approaches. We have organized the publications into topic areas that include:  \n1. Context and public health  \n2. Etiology and biological basis  \na. Mechanisms  \nb. Genetics ","cbCaidoVeOU3sTki","https://ap.wps.com/l/cbCaidoVeOU3sTki","pdf",512124,"English","# Editorial\n## Down syndrome as an early window into Alzheimer’s disease\n## Research transformation via international cohorts and funding\n## Special issue scope and contributions\n## Topic areas\n## Open access and publication notes","[{\"question\":\"Why is Alzheimer’s disease research in Down syndrome considered uniquely valuable?\",\"answer\":\"DS provides a predictable, accelerated pathway to AD neuropathology, enabling study of molecular and cellular origins long before symptoms emerge.\"},{\"question\":\"Which research efforts are highlighted as reshaping DS-associated AD studies?\",\"answer\":\"Large international initiatives are described, including the Alzheimer’s Biomarker Consortium–Down Syndrome (ABC-DS), DABNI, Horizon 21, and TRC-DS, along with increased NIH/NIA support via the INCLUDE project.\"},{\"question\":\"What kinds of data do the DS-associated AD cohorts provide?\",\"answer\":\"The cohorts generate longitudinal, multimodal information spanning clinical, cognitive, fluid, imaging, and genetic measures for harmonized comparisons.\"}]","Novel insights into Alzheimer’s disease through the study of individuals with Down syndrome - Editorial | PDF",1790750728]