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The study centers on personalized medicine guidance, using renin-angiotensin system phenotyping to anticipate responses to ACE inhibition, and examines how genetic variation and gender influence bradykinin type 1 receptor responses in human tissue. It also investigates how genomic instability affects responsiveness to angiotensin II receptor signaling, and evaluates dietary restriction as a strategy to improve vasodilator dysfunction driven by accelerated vascular aging. Includes summary, discussion, and supporting academic materials such as publications and curriculum vitae.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/novel-directions-in-therapy-against-age-related-vascular-disease/292524/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/novel-directions-in-therapy-against-age-related-vascular-disease/292524.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-17",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the dissertation’s main research focus?","Question",{"text":112,"@type":113},"The dissertation investigates therapeutic directions for age-related vascular disease, emphasizing personalized treatment guidance and mechanisms affecting vascular function.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the thesis approach personalized medicine for ACE inhibitors?",{"text":117,"@type":113},"It evaluates renin-angiotensin system phenotyping to determine whether patient response to ACE inhibition can be predicted from plasma renin or ACE.",{"name":119,"@type":110,"acceptedAnswer":120},"Which factors are studied regarding receptor responses in patients?",{"text":121,"@type":113},"The work examines how genetic variation and gender influence bradykinin type 1 receptor responses and how genomic instability alters responsiveness to angiotensin II signaling.",{"name":123,"@type":110,"acceptedAnswer":124},"What intervention is evaluated to address vascular aging effects?",{"text":125,"@type":113},"The thesis studies dietary restriction and its potential to improve vasodilator dysfunction caused by accelerated vascular aging due to genomic instability.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},292524,1789652456,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":133,"read_time":148,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Novel Directions In Therapy Against Age-Related Vascular Disease  \nHaiyan Wu  \nNovel Directions In Therapy Against Age-Related Vascular Disease  \nISBN: 978-94-6203-614-7  \nCover : Photo from EisukeTachikawa  \nDesign, cover desigen and layout: Haiyan Wu  \nPrinting: CPI Koninklijke Wöhrmann Copyright © HaiyanWu Rotterdam, 2014  \nAll right reserved. No part of this thesis maybe reproduced, stored in a retrieval system of any nature, or transmitted in any form or means, without written permission of the author, or when appropriate, of the publishers of the publications.  \nNOVEL DIRECTIONS IN THERAPY AGAINST AGE-RELATED VASCULAR DISEASE  \nNieuwe richting in therapie tegen leeftijd-gerelateerde vasculaire ziekte  \nProefschrift  \nter verkrijging van de graad van doctor aan de Erasmus Universiteit Rotterdam op gezag van de rector magnificus Prof.dr. H.A. P. Pols  \nen volgens besluit van het College voor Promoties De openbare verdediging zal plaatsvinden op donderdag 25 september 2014 om 11.30 uur door Haiyan Wu geboren te Guizhou (China)  \nPromotie commissie  \nPromotor: Prof.dr. A. H.J. Danser  \nOverige leden: Prof.dr. R. H. Henning  \nProf.dr. J. H.J. Hoeijmakers  \nProf.dr. E.J.G. Sijbrands  \nCopromotor: Dr. A.J.M. Roks  \nFinancial support for the publication of this thesis was generously provided by Erasmus University Rotterdam  \nFinancial support by The Dutch Heart Foundation for the publication of this thesis is gratefully acknowledge  \nThis studies described in this thesis were supported by a grant of the China Scholarship Council (2010624026)  \nThis work is dedicated to my family  \n谨以此书献给我的家人  \nTABLE OF CONTENTS  \nChapter 1 General Introduction 9  \nChapter 2 Renin-angiotensin system phenotyping as guidance 31  \ntoward personalized medicine for ACE inhibitors:  \ncan the response to ACE inhibition be predicted on the  \nbasis of plasma renin or ACE?  \nChapter 3 Genetic variation and gender determine bradykinin 53  \ntype 1 receptor responses in human tissue: implications  \nfor the ACE inhibitor-induced effects in patients with  \ncoronary artery disease  \nChapter 4 The effect of genomic instability on responsiveness 69  \nto angiotensin II type 1 receptor stimulation and blockade  \nChapter 5 Dietary restriction improves vasodilator dysfunction caused 85  \nby accelerated vascular aging due to genomic instability  \nChapter 6 Summary and general discussion 103  \nSamenvatting  \nPhD portfolio  \nList of Publications  \nCurriculum vitae  \nAcknowledgements  \n\n|  |\n| --- |\n| Chapter 1\u003Cbr>General introduction |\n| Partly published as: Genomic instability and vascular aging: a focus on nucleotide excision repair\u003Cbr>Haiyan Wu, Anton J.M. Roks\u003Cbr>Dept. of Internal Medicine, Division of Vascular Medicine & Pharmacology, Erasmus Medical Center Rotterdam, The Netherlands\u003Cbr>Trends Cardiovasc Med. 2014;24:61-68 . |","cbCaiatqbtFQL2L4","https://ap.wps.com/l/cbCaiatqbtFQL2L4","pdf",3259789,126,"English","# TABLE OF CONTENTS\n## Chapter 1 - General Introduction\n## Chapter 2 - Renin-angiotensin system phenotyping as guidance toward personalized medicine for ACE inhibitors\n## Chapter 3 - Genetic variation and gender determine bradykinin type 1 receptor responses\n## Chapter 4 - The effect of genomic instability on responsiveness to angiotensin II type 1 receptor stimulation and blockade\n## Chapter 5 - Dietary restriction improves vasodilator dysfunction caused by accelerated vascular aging due to genomic instability\n## Chapter 6 - Summary and general discussion\n## Samenvatting\n## PhD portfolio\n## List of Publications\n## Curriculum vitae\n## Acknowledgements","[{\"question\":\"What is the dissertation’s main research focus?\",\"answer\":\"The dissertation investigates therapeutic directions for age-related vascular disease, emphasizing personalized treatment guidance and mechanisms affecting vascular function.\"},{\"question\":\"How does the thesis approach personalized medicine for ACE inhibitors?\",\"answer\":\"It evaluates renin-angiotensin system phenotyping to determine whether patient response to ACE inhibition can be predicted from plasma renin or ACE.\"},{\"question\":\"Which factors are studied regarding receptor responses in patients?\",\"answer\":\"The work examines how genetic variation and gender influence bradykinin type 1 receptor responses and how genomic instability alters responsiveness to angiotensin II signaling.\"},{\"question\":\"What intervention is evaluated to address vascular aging effects?\",\"answer\":\"The thesis studies dietary restriction and its potential to improve vasodilator dysfunction caused by accelerated vascular aging due to genomic instability.\"}]","Novel Directions In Therapy Against Age-Related Vascular Disease | PDF",318]