[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332098-105":59,"doc-detail-332098-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","notch-signaling-pathway-in-cancer-from-mechanistic-insights-to-targeted-therapies","Notch signaling pathway in cancer - from mechanistic insights to targeted therapies","","Notch signaling is a conserved receptor–ligand pathway that regulates cell fate, development, and tissue homeostasis, yet its dysregulation drives cancer initiation and progression. The review describes how abnormal Notch activity promotes epithelial–mesenchymal transition, angiogenesis, stem-like features, metabolic reprogramming, and shaping of the tumor microenvironment, while also contributing to chemoresistance. It further explains mechanistic links to tumorigenesis and summarizes clinical investigations of drugs targeting Notch signaling for human malignancies.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/notch-signaling-pathway-in-cancer-from-mechanistic-insights-to-targeted-therapies/332098/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/notch-signaling-pathway-in-cancer-from-mechanistic-insights-to-targeted-therapies/332098.png","ImageObject",300,407,{"name":92,"@type":93},"Ivy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does Notch signaling contribute to cancer progression?","Question",{"text":113,"@type":114},"Dysregulated Notch signaling promotes epithelial–mesenchymal transition, angiogenesis, stem-like properties, and supports tumor energy metabolism, which collectively enhance proliferation, invasion, and metastasis.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What mechanisms connect Notch signaling to chemoresistance?",{"text":118,"@type":114},"The review indicates that Notch signaling is implicated in conferring chemoresistance to tumor cells, linking pathway dysregulation to therapy failure.",{"name":120,"@type":111,"acceptedAnswer":121},"What is the purpose of targeting Notch signaling in cancer treatment?",{"text":122,"@type":114},"Because Notch signaling can balance oncogenic and tumor-suppressive effects, understanding its mechanisms supports developing innovative therapeutic strategies and informs pharmaceutical clinical trials targeting the pathway.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332098,1790195421,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},549758252649,"https://ap-avatar.wpscdn.com/avatar/8000253669c5317157?_k=1778319167496531819","Signal Transduction [and Targeted Therapy](and Targeted Therapy www.nature.com/sigtrans)[ www.nature.com/sigtrans](and Targeted Therapy www.nature.com/sigtrans)  \nREVIEW ARTICLE  \nOPEN  \nNotch signaling pathway in cancer: from mechanistic insights to targeted therapies  \nQingmiao Shi 1, Chen Xue 1, Yifan Zeng1, Xin Yuan1, Qingfei Chu 1, Shuwen Jiang 1, Jinzhi Wang 1, Yaqi Zhang1, Danhua Zhu1 ✉ and Lanjuan Li 1 ✉  \n\n| | Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are transmembrane proteins containing epidermal growth factor-like repeat sequences, typically necessitating receptor-ligand interaction to initiate classical Notch signaling transduction. Accumulating evidence indicates that the Notch signaling pathway serves as both an oncogenic factor and a tumor suppressor in various cancer types. Dysregulation of this pathway promotes epithelial-mesenchymal transition and angiogenesis in malignancies, closely linked to cancer proliferation, invasion, and metastasis. Furthermore, the Notch signaling pathway contributes to maintaining stem-like properties in cancer cells, thereby enhancing cancer invasiveness. The regulatory role of the Notch signaling pathway in cancer metabolic reprogramming and the tumor microenvironment suggests its pivotal involvement in balancing oncogenic and tumor suppressive effects. Moreover, the Notch signaling pathway is implicated in conferring chemoresistance to tumor cells. Therefore, a comprehensive understanding of these biological processes is crucial for developing innovative therapeutic strategies targeting Notch signaling. This review focuses on the research progress of the Notch signaling pathway in cancers, providing in-depth insights into the potential mechanisms of Notch signaling regulation in the occurrence and progression of cancer. Additionally, the review summarizes pharmaceutical clinical trials targeting Notch signaling for cancer | |\n| --- | --- | --- |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  | |\n|  |  |  |\n| | therapy, aiming to offer new insights into therapeutic strategies for human malignancies. | |\n|  | Signal Transduction and Targeted Therapy (2024)9:128 ; [https://doi.org/10.1038/s41392-024-01828-x](https://doi.org/10.1038/s41392-024-01828-x) |  |\n|  |  |  |\n\nINTRODUCTION  \nThe Notch locus was initially identified in 1917 through genetic studies involving a mutant strain of Drosophila melanogaster exhibiting notched wings.1 The Drosophila Notch gene was subsequently isolated in 1983 .2 It was later revealed that the protein encoded by the Notch gene functions as a transmembrane receptor with multiple epidermal growth factor (EGF)-like repeats, typically activated by transmembrane ligands expressed on adjacent cells.3 To date, Notch receptors and ligands have been discovered in various metazoans, serving as integral components of the Notch signaling cascade and participating in diverse biological processes such as cell fate determination, embryonic development, organ formation, and tissue repair.4,5  \nExtensive research has been conducted on Notch signaling pathway, investigating its role as an oncogene or tumor suppressor in various cellular contexts. The involvement of the Notch signaling pathway in human malignancies was initially elucidated in T cell acute lymphoblastic leukemia (T-ALL), where the chromosomal translocation t(7;9) (q34;q34.3) results in the truncation of Notch1 transcripts.6 Subsequent cancer genome sequencing has unveiled widespread oncogenic Notch gene mutations in diverse human cancers, such as cutaneous and lungsquamous cell carcinoma (LUSC),7 breast cancer,8 anaplastic large  \ncell lymphoma,9 and chronic lymphocytic leukemia (CLL) .10 Moreover, accumulating evidence indicates that the dysregulation of the Notch sig","cbCainwd4xq2GqEI","https://ap.wps.com/l/cbCainwd4xq2GqEI","pdf",5479770,37,"English","# Introduction\n# Overview of Notch signaling in cancer\n# Mechanistic roles in tumor progression\n# Targeted therapies and clinical trials","[{\"question\":\"How does Notch signaling contribute to cancer progression?\",\"answer\":\"Dysregulated Notch signaling promotes epithelial–mesenchymal transition, angiogenesis, stem-like properties, and supports tumor energy metabolism, which collectively enhance proliferation, invasion, and metastasis.\"},{\"question\":\"What mechanisms connect Notch signaling to chemoresistance?\",\"answer\":\"The review indicates that Notch signaling is implicated in conferring chemoresistance to tumor cells, linking pathway dysregulation to therapy failure.\"},{\"question\":\"What is the purpose of targeting Notch signaling in cancer treatment?\",\"answer\":\"Because Notch signaling can balance oncogenic and tumor-suppressive effects, understanding its mechanisms supports developing innovative therapeutic strategies and informs pharmaceutical clinical trials targeting the pathway.\"}]","Notch signaling pathway in cancer - from mechanistic insights to targeted therapies | PDF",1789996761,93]