[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426963-105":59,"doc-detail-426963-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","noradrenergic-locus-coeruleus-hyperactivity-alters-attention-in-cognitively-healthy-older-adults","NORADRENERGIC LOCUS COERULEUS HYPERACTIVITY ALTERS ATTENTION IN COGNITIVELY HEALTHY OLDER ADULTS","","NORADRENERGIC LOCUS COERULEUS HYPERACTIVITY ALTERS ATTENTION IN COGNITIVELY HEALTHY OLDER ADULTS investigates whether aging in humans reflects tonic locus coeruleus–noradrenaline hyperactivity. The study tested cognitively healthy older adults using electrophysiological, pupillometric, and behavioral measures during passive and active auditory oddball tasks, with arousal modulated via threat of electric shock. Older adults showed reduced task-evoked behavioral, pupil dilation, and P300 responses, alongside arousal-by-modality effects on attentional control toward salient distractors. Results support non-invasive markers of LC-NA function across aging and potential risk identification before clinical biomarkers emerge.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/noradrenergic-locus-coeruleus-hyperactivity-alters-attention-in-cognitively-healthy-older-adults/426963/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/noradrenergic-locus-coeruleus-hyperactivity-alters-attention-in-cognitively-healthy-older-adults/426963.png","ImageObject",300,407,{"name":92,"@type":93},"mieayamfan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-12","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What core question does the study address about aging and locus coeruleus function?","Question",{"text":112,"@type":113},"It tests whether cognitively healthy older adults sustain tonic locus coeruleus (LC) hyperactivity, indicating age-related alterations in the LC–noradrenaline system in humans.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the researchers manipulate arousal in the experiment?",{"text":117,"@type":113},"They capitalized on the LC–noradrenaline system’s role in arousal regulation and manipulated state arousal using the threat of electric shock.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find regarding arousal-related responses in older versus young adults?",{"text":121,"@type":113},"Arousal produced weaker behavioral responses, smaller pupil dilation responses, and reduced P300 event-related potentials in older adults compared with young adults.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},426963,1791026879,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},962090893677,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","1138 Innovation in Aging, 2025, Vol. 9, No. S2  \nWe hypothesized that if older adults maintain elevated LC activity compared with young adults, task-evoked noradrenergic responses would be less responsive to arousal in older adults. Consistent with this hypothesis, arousal elicited weaker behavioral responses, pupil dilation responses, and P300 event-related potentials in older adults compared with young adults. Linear mixed models revealed an arousal by modality interaction and revealed that arousal differentially modulated attentional control to salient but task-irrelevant distractors between both age groups. Collectively, these findings support the hypothesis that aging is associated with tonic LC-NA system hyperactivity in humans, with downstream consequences for mechanisms of attentional control. These multimodal findings underscore the potential of non-invasive physiological markers to assess LC-NA system function throughout aging and identify individuals at elevated risk for neurodegenerative progression prior to the emergence of clinical biomarkers.  \nAbstract citation ID: igaf122.3817  \nNORADRENERGIC LOCUS COERULEUS  \nHYPERACTIVITY ALTERS ATTENTION IN  \nCOGNITIVELY HEALTHY OLDER ADULTS  \nJoshua Senior1, Andy Kim2, Santiago Morales3, and  \nMara Mather2, 1. Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States,  \n2. Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States,  \n3. University of Southern California, Los Angeles, California, United States  \nAnimal models of Alzheimer’s disease have shown that neuropathology in the locus coeruleus (LC) leads to increased neuronal firing, while human studies demonstrate that age-related dysregulation of the LC-noradrenaline (LC-NA) system is associated with cognitive decline. However, due to limitations indirectly measuring LC function in vivo, it remains unclear whether age-related alterations in humans reflect tonic LC-NA system hyperactivity. In this study, we tested the hypothesis that cognitively healthy older adults sustain tonic LC hyperactivity, by acquiring electrophysiological, pupillometric, and behavioral measures during a passive and active auditory oddball paradigm.  \nWe capitalized on the LC-NA system’s role in arousal regulation and manipulated state arousal using the threat of electric shock.","cbCaisPDyglJNpXx","https://ap.wps.com/l/cbCaisPDyglJNpXx","pdf",1002444,"English","# Introduction\n# Methods\n# Results\n# Conclusions and Implications","[{\"question\":\"What core question does the study address about aging and locus coeruleus function?\",\"answer\":\"It tests whether cognitively healthy older adults sustain tonic locus coeruleus (LC) hyperactivity, indicating age-related alterations in the LC–noradrenaline system in humans.\"},{\"question\":\"How did the researchers manipulate arousal in the experiment?\",\"answer\":\"They capitalized on the LC–noradrenaline system’s role in arousal regulation and manipulated state arousal using the threat of electric shock.\"},{\"question\":\"What did the study find regarding arousal-related responses in older versus young adults?\",\"answer\":\"Arousal produced weaker behavioral responses, smaller pupil dilation responses, and reduced P300 event-related potentials in older adults compared with young adults.\"}]","NORADRENERGIC LOCUS COERULEUS HYPERACTIVITY ALTERS ATTENTION IN COGNITIVELY HEALTHY OLDER ADULTS | PDF",1790642337]