[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-448061-105":59,"doc-detail-448061-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","noncoding-rnas-in-chronic-wound-healing-mechanisms-exosome-therapeutics-and-translational-frontiers","Noncoding RNAs in Chronic Wound Healing - Mechanisms, Exosome Therapeutics, and Translational Frontiers","","Chronic wounds represent major clinical challenges driven by dysregulated inflammation, impaired angiogenesis, and abnormal extracellular matrix (ECM) remodeling. Noncoding RNAs (ncRNAs), including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), regulate these processes and form competitive endogenous RNA (ceRNA) networks that tune miRNA activity and target gene expression. Exosome-based delivery, supported by gene editing or chemical modification, enables efficient, targeted ncRNA transport. Hydrogels can extend exosome half-life for sustained release. The review also highlights machine learning and AI to accelerate personalized ceRNA network prediction and smart hydrogel dressing design for specific wound types.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/noncoding-rnas-in-chronic-wound-healing-mechanisms-exosome-therapeutics-and-translational-frontiers/448061/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/noncoding-rnas-in-chronic-wound-healing-mechanisms-exosome-therapeutics-and-translational-frontiers/448061.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How do noncoding RNAs influence chronic wound healing?","Question",{"text":113,"@type":114},"Noncoding RNAs regulate dysregulated inflammation, angiogenesis, and extracellular matrix remodeling. They also build competitive endogenous RNA (ceRNA) networks that adjust miRNA activity and target gene expression.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why are exosomes considered promising for ncRNA therapeutics?",{"text":118,"@type":114},"Exosomes can deliver ncRNAs with high efficiency and targeting. Gene editing or chemical modification can further support this delivery approach in preclinical settings.",{"name":120,"@type":111,"acceptedAnswer":121},"How can hydrogels improve exosome-based ncRNA delivery?",{"text":122,"@type":114},"Combining exosomes with hydrogel biomaterials can prolong exosome half-life and enable continuous release of ncRNAs, supporting sustained therapeutic effects.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},448061,1791072373,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","Noncoding RNAs in chronic wound healing: Mechanisms, exosome therapeutics, and translational frontiers  \nJournal of Tissue Engineering Volume 17: 1–31 © The Author(s) 2026 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/20417314251410000](DOI: 10.1177/20417314251410000)[ ](DOI: 10.1177/20417314251410000)[journals.sagepub.com/home/tej](journals.sagepub.com/home/tej)  \nLingjing Yang 1,2 and Yehui Lv 1,2  \nAbstract  \nChronic wounds have become major clinical problems due to dysregulated inflammation, impaired angiogenesis, and abnormal extracellular matrix (ECM) remodeling. Noncoding RNA (ncRNA), including microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA), serve as key molecules to regulate these pathological processes. These ncRNA also constructs a competitive endogenous RNA (ceRNA) network to precisely adjust miRNA activity and target gene expression. Through gene editing or chemical modification, exosomes achieve ncRNA delivery with high efficiency and targeting and show exciting promise in preclinical models. Combining with biomaterials such as hydrogels can prolong the exosome half-life and achieve the continuous release of ncRNA. In addition, researchers explore how machine learning (ML) and artificial intelligence (AI) could advance future therapeutic applications. Drug delivery system can be improved both by predicting personalized ceRNA networks for individual patients, and designing smart wound dressings that combine exosomes with hydrogel materials tailored to specific wound types. By integrating these recent advances, this review helps bridge basic research and the future creation of targeted chronic wound treatments.  \nKeywords  \nwound healing, noncoding RNA, exosomes, competing endogenous RNA, hydrogels, bioengineering strategies  \nReceived: 9 August 2025; accepted: 9 December 2025  \nIntroduction  \nThe skin is the largest organ system in the human body and could effectively protect against mechanical damage, infection, and fluid and heat imbalances. After skin damage, wounds will form and start to heal. Wound healing is a complex process that requires a variety of cells to work together, with various cytokines and biomolecules involved. In general, this process can be divided into three main stages: inflammation, proliferation and remodeling.1 The inflammatory phase is the beginning of wound healing, when the skin is injured, inflammatory cells are recruited to the site of wounded area. The proliferative phase is characterized by the accumulation of new cells and connective tissue. Keratinocytes (KCs) and endothelial cells become key players in this stage. The remodeling phase is the final step and requires a precise balance between apoptosis of existing cells and the generation of new cells. Alterations at any stage can affect normal wound healing under the influence of various internal and external  \nfactors. Chronic diseases such as diabetes reduce the rate of wound healing and create chronic wounds such as diabetic foot ulcers (DFUs), which cause microbial infections and often lead to amputations.2 Excessive wound healing, including hypertrophic scars and keloids, often leads to itching and pain, which reduces quality of life. Traditional therapies often fail to cope with this complexity. This highlights the urgent need for new molecular understanding and targeted interventions.  \n1 Institute of Wound Prevention and Treatment, Shanghai University of Medicine & Health Sciences, China  \n2School of Basic Medicine, Shanghai University of Medicine & Health Sciences, China  \nCorresponding author:  \nYehui Lv, School of Basic Medicine, Shanghai University of Medicine & Health Sciences, 279 Zhouzhu Road, Pudong New Area, Shanghai 201318, China.  \nEmail: [lvyh_15@sumhs.edu.cn](lvyh_15@sumhs.edu.cn)  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative ","cbCaio40EliS3HWa","https://ap.wps.com/l/cbCaio40EliS3HWa","pdf",1316573,31,"English","# Introduction\n## Stages of wound healing and dysfunction in chronic wounds\n## Clinical consequences of chronic wound complications\n## Rationale for targeted molecular interventions\n# Noncoding RNAs in wound healing\n## Regulatory ncRNAs and signaling control\n## ceRNA networks and miRNA-target regulation\n# Exosome therapeutics for ncRNA delivery\n## Efficient targeted delivery mechanisms\n## Sustained release strategies with hydrogels\n# Future directions\n## Machine learning and artificial intelligence for personalization\n## Smart wound dressing concepts","[{\"question\":\"How do noncoding RNAs influence chronic wound healing?\",\"answer\":\"Noncoding RNAs regulate dysregulated inflammation, angiogenesis, and extracellular matrix remodeling. They also build competitive endogenous RNA (ceRNA) networks that adjust miRNA activity and target gene expression.\"},{\"question\":\"Why are exosomes considered promising for ncRNA therapeutics?\",\"answer\":\"Exosomes can deliver ncRNAs with high efficiency and targeting. Gene editing or chemical modification can further support this delivery approach in preclinical settings.\"},{\"question\":\"How can hydrogels improve exosome-based ncRNA delivery?\",\"answer\":\"Combining exosomes with hydrogel biomaterials can prolong exosome half-life and enable continuous release of ncRNAs, supporting sustained therapeutic effects.\"}]","Noncoding RNAs in Chronic Wound Healing - Mechanisms, Exosome Therapeutics, and Translational Frontiers | PDF",1790725011,78]