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It reports multisite validation results and compares test performance with magnetic resonance imaging (MRI) to assess agreement and potential clinical utility. The work focuses on risk stratification for patients whose disease may progress while avoiding unnecessary invasive procedures, supporting more precise decision-making in active surveillance programs.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/non-invasive-urine-test-predicts-grade-group-upgrading-in-patients-on-active-surveillance-for-prostate-cancer-multisite-validation-and-comparison-with-mri/360827/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/non-invasive-urine-test-predicts-grade-group-upgrading-in-patients-on-active-surveillance-for-prostate-cancer-multisite-validation-and-comparison-with-mri/360827.png","ImageObject",300,407,{"name":92,"@type":93},"Well Done","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What does the urine test predict in active surveillance patients?","Question",{"text":112,"@type":113},"The urine test is designed to predict Grade Group upgrading in patients with prostate cancer who are managed on active surveillance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is the study strengthened by using multisite validation?",{"text":117,"@type":113},"Multisite validation assesses whether the test’s predictive performance generalizes across different sites rather than being limited to a single cohort.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the urine test relate to MRI in the study?",{"text":121,"@type":113},"The study compares the urine test’s results with MRI to evaluate how the two approaches align and differ for predicting upgrading.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},360827,1790211173,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909892210082,"https://ap-avatar.wpscdn.com/avatar/56001069da27c9f41e8?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789614185077863061","Author Manuscript Author Manuscript Author Manuscript Author Manuscript  \n\n| | HHS Public Access\u003Cbr>Author manuscript\u003Cbr>J Urol. Author manuscript; available in PMC 2026 July 09. |\n| --- | --- |\n\nPublished in final edited form as:  \nJ Urol. 2026 September ; 216(3): 369–379. doi:10.1097/JU.0000000000005095 .  \nNon-Invasive Urine Test Predicts Grade Group Upgrading in Patients on Active Surveillance for Prostate Cancer: Multisite Validation and Comparison with MRI  \n*  \nJeffrey J. Tosoian, MD, MPH ,  \nDepartment of Urology, Vanderbilt University Medical Center; Vanderbilt-Ingram Cancer Center, Nashville, TN  \nJacob I. Meyers, PhD* , Lynx Dx, Ann Arbor, MI  \nBradley Moore, MPH, Lynx Dx, Ann Arbor, MI  \nCameron J. Britton, MD,  \nDepartment of Urology, Vanderbilt University Medical Center, Nashville TN Kent Chevli, MD,  \nWestern New York Urology Associates, Cheektowaga, NY  \nWalter Rayford, MD, PhD, MBA, The Urology Group, Memphis, TN  \nAdam J. Gadzinski, MD, MS,  \nComprehensive Urology, Royal Oak, MI  \nJean V. Joseph, MD, MBA, FACS,  \nDepartment of Urology, University of Rochester Medical Center, Rochester, NY  \nPratik Patel, MD,  \nArizona State Urological Institute (ASUI) and Arizona State Urological Research Institute (ASURI), Gilbert, AZ  \nThis work is licensed under a Creative Commons Attribution 4.0 International License, which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.  \nCorresponding Author Information: Jeffrey J. Tosoian, MD, MPH, Department of Urology, Vanderbilt University Medical Center, A* C- 3-02firsMedit authcoCenter North, 1161 21st Avenue South Nashville, TN 37232-2765, Fax: 615-322-8990, [jeff.tosoian@vumc.org](jeff.tosoian@vumc.org). Disclosures: Dr. Barocas reported being on the advisory board for Pfizer, Lantheus, Lynx Dx, and Pacific Edge. Dr. Chinnaiyan reported serving on the advisory boards of Tempus, Ascentage Pharmaceuticals, Medsyn therapeutics, Esanik, and RAAPTA therapeutics. Drs. Chinnaiyan and Tosoian reported being scientific advisors and equity holders to Lynx Dx. Dr. Cooperberg reported being scientific advisor to Tempus, Veracyte, GlaxoSmithKline, Pfizer, Bayer, and Janssen as well as equity holding in Lynx Dx.  \nDr. Morgan reported being on the advisory board for Cleveland Diagnostics. Dr. Palapattu reported being on the advisory board for Continuity Biosciences, SynDevRx, Taurus Diagnostics, and Lynx Dx, and investment in Continuity Biosciences and ImmunityBio. Dr. Ross reported being a consultant or speaker for Astellas, Blue Earth, Bayer, Janssen, Pfizer, BilliontoOne, Lantheus, Veracyte, and Boston Scientific. Dr. Salami reported being on the advisory committee for Bayer Pharma. Dr. Salari reported research funding support from Convergent Genomics. Dr. Meyers, Mr. Moore, Dr. Cao, Mr. Bala, Mr. Oh, Dr. Heaton reported being employees of Lynx Dx. No other conflicts of interest were reported.  \nAuthor Manuscript Author Manuscript Author Manuscript Author Manuscript  \nTosoian et al. Page 2  \nAli Kasraeian, MD, MHA, FACS, Kasraeian Urology, Jacksonville, FL  \nPrithipal S. Sethi, MD,  \nGolden State Urology, Sacramento, CA  \nHunter S. Robinson, MD,  \nGeisinger Medical Center, Department of Urology, Danville, PA  \nKeavash D. Assani, MD,  \nDepartment of Urology, Vanderbilt University Medical Center; Nashville, TN  \nVijay Rings, MD,  \nDepartment of Urology, Vanderbilt University Medical Center; Nashville, TN  \nJanene Pierce, BS,  \nDepartment of Urology, Vanderbilt University Medical Center; Nashville, TN  \nKristen R. Scarpato, MD, MPH,  \nDepartment of Urology, Vanderbilt University Medical Center; Nashville, TN  \nKelvin A. Moses, MD, PhD,  \nDepartment of Urology, Vanderbilt University Medical Center; Nashville, TN  \nDaniel A. Barocas, MD, MPH,  \nDepartment of Urology, Vanderbilt University Medical Center; Vanderbilt-Ingram Cancer Center, Nashville, TN  \nSam S. Ch","cbCaicErRK5ksJ72","https://ap.wps.com/l/cbCaicErRK5ksJ72","pdf",325926,21,"English","# Background and Objective\n## Multisite Validation\n## Comparison With MRI\n## Clinical Implications for Active Surveillance","[{\"question\":\"What does the urine test predict in active surveillance patients?\",\"answer\":\"The urine test is designed to predict Grade Group upgrading in patients with prostate cancer who are managed on active surveillance.\"},{\"question\":\"How is the study strengthened by using multisite validation?\",\"answer\":\"Multisite validation assesses whether the test’s predictive performance generalizes across different sites rather than being limited to a single cohort.\"},{\"question\":\"How does the urine test relate to MRI in the study?\",\"answer\":\"The study compares the urine test’s results with MRI to evaluate how the two approaches align and differ for predicting upgrading.\"}]","Non-Invasive Urine Test Predicts Grade Group Upgrading in Patients on Active Surveillance for Prostate Cancer - Multisite Validation and Comparison with MRI | PDF",1790141718,53]