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Prior research highlights dual cancer effects: restriction of tumorigenesis early yet promotion of tumor progression in specific cancers. Evidence indicates that microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) drive hepatocellular carcinoma (HCC) development, invasion, and drug resistance by governing HCC cell autophagy. This review summarizes key miRNA and lncRNA functions and related mechanisms to inform novel HCC therapeutics.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/non-coding-rnas-role-of-mirnas-and-lncrnas-in-the-regulation-of-autophagy-in-hepatocellular-carcinoma-review/405625/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/non-coding-rnas-role-of-mirnas-and-lncrnas-in-the-regulation-of-autophagy-in-hepatocellular-carcinoma-review/405625.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is autophagy and why is it relevant to hepatocellular carcinoma (HCC)?","Question",{"text":112,"@type":113},"Autophagy is a multistep lysosomal degradation process that supports nutrient cycling and metabolic adaptation. In HCC it can influence cancer occurrence and development, including tumor growth and survival depending on the stage and context.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) relate to HCC autophagy?",{"text":117,"@type":113},"miRNAs and lncRNAs are described as regulators that govern HCC cell autophagy. By affecting autophagy, they are linked to HCC occurrence, invasion, development, drug resistance, and migration.",{"name":119,"@type":110,"acceptedAnswer":120},"What does the review aim to provide for HCC therapeutics?",{"text":121,"@type":113},"The review highlights the significant functions of miRNAs and lncRNAs in regulating autophagy in HCC and the relevant mechanisms. The stated goal is to provide novel insights to support HCC therapeutic development.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},405625,1790823120,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","ONCOLOGY REPORTS 49: 113, 2023  \nNon‑coding RNAs: Role of miRNAs and lncRNAs in the regulation of autophagy in hepatocellular carcinoma (Review)  \nJIA WU 1 , YING ZHU 1 , QINGWEI CONG 1 and QIUMIN XU2  \n1Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University; 2Administrative Department, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China  \nReceived December 1, 2022; Accepted March 29, 2023  \nDOI: 10. 3892/or.2023.8550  \nAbstract. The term autophagy describes a process that supports nutrient cycling and metabolic adaptation that is accomplished via multistep lysosomal degradation . These activities modulate cell, tissue and internal environment stability, and can also affect the occurrence and development of cancer. Previous studies have mostly described autophagyas having dual effects in cancer, serving to limit tumorigenesis in the early stages of cancer, but promoting tumor progres‑ sion in certain types of cancer. There have been indicationsin recent years that microRNAs (miRNAs/miRs) and long non‑coding RNAs (lncRNAs), as types of non‑coding RNAs, play major roles in the occurrence, invasion, development and drug resistance of hepatocellular carcinoma (HCC) and in the migration of HCC cells by governing HCC cell autophagy. Therefore, understanding which miRNAs and lncRNAs play such roles and the relevant molecular mechanisms is critical. The present review highlights the significant functions of miRNAs and lncRNAs in the regulation of autophagy in HCCand the relevant mechanisms, aiming to provide novel insight into HCC therapeutics.  \nContents  \n1. Introduction  \n2. miRNAs involved in the regulation of autophagy in HCC  \n3. lncRNAs involved in the regulation of autophagy in HCC  \nCorrespondence to: Professor Ying Zhu, Department of Infectious Diseases, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Xigang, Dalian, Liaoning 116000, P.R. China  \nE‑mail: [zhuyingsh52@126.com](zhuyingsh52@126.com)  \nProfessor Qiumin Xu, Administrative Department, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Xigang, Dalian, Liaoning 116000, P.R. China  \nE‑mail: [xuqm@dmu.edu.cn](xuqm@dmu.edu.cn)  \nKey words: hepatocellular carcinoma, autophagy, microRNAs, long non‑coding RNAs, non‑coding RNAs  \n4. Mechanisms of miRNAs and lncRNAs in the regulation of autophagy in HCC  \n5. Conclusions and future perspectives  \n1. Introduction  \nCancer is a prominent cause of morbidity and mortality world‑ wide, and hepatocellular carcinoma (HCC) is the third leading cause of cancer‑related mortality (1,2). Autophagy is generally understood to be a process that serves to carry cytoplasmic cargo to lysosomes for degradation, which plays a major role in eukaryotic cells and mammalian survival, as well as in cellular homeostasis, development, tumorigenesis and infection (3,4) . There are three main types of autophagy: Microautophagy, macroautophagy and chaperone‑mediated autophagy (5) . Among the three types of autophagy, macroautophagy, gener‑ ally referred to as ‘autophagy’, is the most critical and most extensively studied form . There is evidence to indicate that autophagy plays a role in inhibiting the growth of tumors, particularly in the liver. In addition to the typical function of autophagy as an inhibitor of tumor development in non‑tumor cells and in early‑stage tumor development, autophagy also enhances tumor cell survival once the tumor has formed (5‑8)(Fig. 1) . Therefore, the inhibition of autophagy has become a novel strategy for anticancer therapeutics (9) .  \nRNAs are transcription products of DNA, and they encompass non‑coding RNAs (ncRNAs) and coding RNAs. Coding RNAs include messenger RNAs (mRNAs), which serve as a template for protein biosynthesis (10) . ncRNAs are transcripts without protein‑coding potential that have multiple biological functions, and they modulate gene expression at multiple l","cbCain6ivBGCAS8C","https://ap.wps.com/l/cbCain6ivBGCAS8C","pdf",1013619,14,"English","# Introduction\n# miRNAs involved in the regulation of autophagy in HCC\n# lncRNAs involved in the regulation of autophagy in HCC\n# Mechanisms of miRNAs and lncRNAs in the regulation of autophagy in HCC\n# Conclusions and future perspectives","[{\"question\":\"What is autophagy and why is it relevant to hepatocellular carcinoma (HCC)?\",\"answer\":\"Autophagy is a multistep lysosomal degradation process that supports nutrient cycling and metabolic adaptation. In HCC it can influence cancer occurrence and development, including tumor growth and survival depending on the stage and context.\"},{\"question\":\"How do microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) relate to HCC autophagy?\",\"answer\":\"miRNAs and lncRNAs are described as regulators that govern HCC cell autophagy. By affecting autophagy, they are linked to HCC occurrence, invasion, development, drug resistance, and migration.\"},{\"question\":\"What does the review aim to provide for HCC therapeutics?\",\"answer\":\"The review highlights the significant functions of miRNAs and lncRNAs in regulating autophagy in HCC and the relevant mechanisms. The stated goal is to provide novel insights to support HCC therapeutic development.\"}]","Non‑coding RNAs: Role of miRNAs and lncRNAs in the regulation of autophagy in hepatocellular carcinoma (Review) | PDF",1790561118,35]