[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331593-105":59,"doc-detail-331593-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","nomograms-for-predicting-the-prognosis-in-multiple-primary-esophageal-squamous-cell-carcinoma","Nomograms for Predicting the Prognosis in Multiple Primary Esophageal Squamous Cell Carcinoma","","Background: Due to the rarity of synchronous multiple primary esophageal squamous carcinomas (sMPESCCs), predicting survival is challenging. The study constructed prognostic nomograms to estimate survival and support treatment strategy. Methods: Retrospective clinical and survival data from 135 patients were analyzed using univariate and multivariate Cox models to identify independent factors and build 1-, 3-, and 5-year DFS and OS nomograms, followed by internal validation. Results: Age, main lesion site, lymph node metastasis, number of dissected lymph nodes, LDH level, and lymphocyte-to-monocyte ratio were independent predictors; C-indexes were 0.752 and 0.756, and decision curve analysis supported model efficacy. Adjuvant therapy improved OS but not DFS in lymph node metastasis.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nomograms-for-predicting-the-prognosis-in-multiple-primary-esophageal-squamous-cell-carcinoma/331593/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nomograms-for-predicting-the-prognosis-in-multiple-primary-esophageal-squamous-cell-carcinoma/331593.png","ImageObject",300,407,{"name":92,"@type":93},"Clementine","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the study’s main objective for patients with synchronous multiple primary esophageal squamous carcinomas?","Question",{"text":113,"@type":114},"To construct nomograms that predict survival outcomes for 1-, 3-, and 5-year disease-free survival and overall survival and to support therapeutic decision-making.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which variables were identified as independent prognostic factors?",{"text":118,"@type":114},"Age, main lesion site, lymph node metastasis, total number of lymph nodes dissected, lactate dehydrogenase level, and the lymphocyte-to-monocyte ratio.",{"name":120,"@type":111,"acceptedAnswer":121},"Did postoperative adjuvant therapy improve survival, and in which patients?",{"text":122,"@type":114},"Postoperative adjuvant therapy significantly benefited overall survival but not disease-free survival in patients with lymph node metastasis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331593,1790555913,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374391974564,"https://ap-avatar.wpscdn.com/avatar/14000253aa45c000a9e?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779874745381141002","AnnAls of Medicine  \n2024, Vol. 56, no. 1, 2433685  \n[https://doi.org/10.1080/07853890.2024.2433685](https://doi.org/10.1080/07853890.2024.2433685)  \nReseaRch aRticle    \nNomograms for predicting the prognosis in multiple primary esophageal squamous cell carcinoma  \nKexi Wanga*, Jian Zhongb* , Danting suc*, changsen lengd,e,f, Jianhua Fud,e,f and Qianwen liud,e,f   \nadepartment of Thoracic surgery, sun Yat-sen Memorial Hospital, Guangzhou, china; bdepartment of Thoracic surgery, Gaozhou People’s Hospital, Maoming, china; cdepartment of Pathology, The seventh Affiliated Hospital of sun Yat-sen University (shenzhen), Guangzhou, china; ddepartment of Thoracic surgery, sun Yat-sen university cancer center, Guangzhou, china; estate Key laboratory of oncology in south china, collaborative innovation center for cancer Medicine, Guangzhou, china; fGuangdong esophageal cancer institute, Guangzhou, china  \nABSTRACT  \nBackground: Due to its rarity, it is challenging to predict the survival of patients with synchronous multiple primary esophageal squamous carcinomas (sMPescs). We aimed to construct nomograms to predict survival outcomes and help to make therapeutic strategy for patients with sMPescs. Materials and Methods: the clinical and survival data of 135 patients with sMPescs were analyzed retrospectively. Univariate and multivariate cox analyses were used to identify independent prognostic factors. Nomograms were constructed to predict 1-year, 3-year and 5-year disease-free survival (DFs) and overall survival (Os). in addition, we further evaluated the effect of postoperative adjuvant therapy on sMPescs patients with lymph node metastasis. Results: in univariate and multivariate analyses of DFs and Os, age, site of the main lesion, lymph node metastasis, total number of lymph nodes dissected, lactate dehydrogenase level and lymphocyte-to-monocyte ratio were identified as independent prognostic factors. these characteristics were further included to establish nomograms. For the internal validation of thenomogram predictions of survival outcomes, the concordance indices were 0.752 and 0.756, respectively. Decision curve analysis also proved the efficacy of the nomograms. Furthermore, adjuvant therapy had a statistically significant benefit for Os but not DFs in patients with lymph node metastasis.  \nConclusions: these nomograms could effectively predict the 1-year, 3-year and 5-year survival outcomes of patients with sMPescs. Furthermore, adjuvant therapy has the potential to improve Os in patients with lymph node metastasis.  \nARTICLE HISTORY  \nReceived 27 November 2023  \nRevised 22 July 2024 accepted 17 October 2024  \nKEYWORDS  \nMultiple esophageal squamous carcinomas; synchronous; survival; nomogram  \nIntroduction  \nMultiple primary esophageal carcinoma is a relatively unusual tumor, defined as two or more carcinomas indifferent parts of the esophagus confirmed by pathologic diagnosis simultaneously or successively. the mechanism of multiple primary cancers may be explained by the theory of field cancerization, which argues that exposure of the epithelium of the aerodigestive tract (e.g. head and neck, esophagus and lung) to carcinogens (e.g. tobacco and alcohol) results in the development of multiple primary tumors [1], but the validity and reliability of this theory has been revisited by recently published article [2] . the incidences of  \npatients with multiple primary esophageal carcinomashave ranged from 1% to 31% in previous studies [3–6] . to date, there have been several studies on the prognosis of synchronous multiple primary esophageal squamous carcinomas (sMPescs) [3,4,7] . however, in these studies, the sample size of patients who underwent surgery was relatively small, and patients who received radical chemoradiotherapy or radiotherapy were also included. in addition, the clinical data of patients are insufficient, such as preoperative blood tests and operation details. the above deficiencies will inevitably affect th","cbCairAiRYYhkGrG","https://ap.wps.com/l/cbCairAiRYYhkGrG","pdf",978279,"English","# Abstract\n# Introduction\n# Material and methods\n## Patient selection","[{\"question\":\"What was the study’s main objective for patients with synchronous multiple primary esophageal squamous carcinomas?\",\"answer\":\"To construct nomograms that predict survival outcomes for 1-, 3-, and 5-year disease-free survival and overall survival and to support therapeutic decision-making.\"},{\"question\":\"Which variables were identified as independent prognostic factors?\",\"answer\":\"Age, main lesion site, lymph node metastasis, total number of lymph nodes dissected, lactate dehydrogenase level, and the lymphocyte-to-monocyte ratio.\"},{\"question\":\"Did postoperative adjuvant therapy improve survival, and in which patients?\",\"answer\":\"Postoperative adjuvant therapy significantly benefited overall survival but not disease-free survival in patients with lymph node metastasis.\"}]","Nomograms for Predicting the Prognosis in Multiple Primary Esophageal Squamous Cell Carcinoma | PDF",1789994230,25]