[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-446873-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-446873-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","nocturnal-gastro-oesophageal-reflux-and-pulmonary-abnormalities-on-chest-ct-in-a-general-population-research-article","Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population - Research Article","","Nocturnal gastro-oesophageal reflux (nGER) is common among people with respiratory conditions, yet its relationship with pulmonary abnormalities on chest CT remains unclear. This study investigated the association between nGER and CT abnormalities in an adult general population, using questionnaire data and chest CT assessment. Overall nGER prevalence was 9.4%, and results differed by presence of additional pulmonary risk factors.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/nocturnal-gastro-oesophageal-reflux-and-pulmonary-abnormalities-on-chest-ct-in-a-general-population-research-article/446873/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/nocturnal-gastro-oesophageal-reflux-and-pulmonary-abnormalities-on-chest-ct-in-a-general-population-research-article/446873.png","ImageObject",300,407,{"name":42,"@type":43},"Blitz","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the primary aim of this study?","Question",{"text":63,"@type":64},"To investigate the association between nocturnal gastro-oesophageal reflux (nGER) and pulmonary abnormalities on chest CT in an adult general population.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were participants with nGER defined and what CT findings were assessed?",{"text":68,"@type":64},"Participants were defined as having nGER if they reported symptoms on at least one night per week. Chest CT was evaluated for bronchial wall thickening, bronchiectasis, reticular abnormalities, honeycombing, cysts, and ground-glass opacities.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the main findings regarding nGER and CT abnormalities?",{"text":72,"@type":64},"In the overall middle-aged general population, nGER was not independently associated with pulmonary abnormalities. However, among individuals with other pulmonary risk factors, nGER showed associations with bronchial wall thickening and reticular abnormalities, and a negative association with cysts.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},446873,1790792737,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Interstitial lung disease  \nOriginal research  \nNocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population: the Swedish CArdioPulmonary BioImage Study  \nÖssur Ingi Emilsson  , 1,2 Andrei Malinovschi  ,3 Åse Johnsson,4,5 Mirjam Ljunggren  , 1 Anders Blomberg,6 Ida Pesonen,7,8 Magnus Sköld,7,8 Zainab Ahmadi,9 Anna Moberg, 10,11 Tomas Hansen 12  \n► Additional supplemental material is published online only. To view, please visit the journal online ([https://doi](https://doi). org/10.1136/thorax-2024- 222570) .  \nFor numbered affiliations see end of article.  \nCorrespondence to  \nDr Össur Ingi Emilsson;  \n[ossur.emilsson@medsci.uu.se](ossur.emilsson@medsci.uu.se)  \nReceived 10 October 2024 Accepted 18 July 2025  \n© Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group.  \nTo cite: Emilsson ÖI, Malinovschi A, Johnsson Å, et al. Thorax Epub ahead of print: [please include Day Month Year] . doi:10 . 1136/ thorax-2024-222570  \nABSTRACT  \nBackground Nocturnal gastro-oesophageal reflux (nGER) is common in people with respiratory diseases, but its association with pulmonary abnormalities is not known.  \nAim Investigate the association between nGER and pulmonary abnormalities on chest CT in an adult general population.  \nMethods In total, 28 846 individuals from the general population aged 50–64 years completed questionnaires and underwent chest CT, in the Swedish CArdioPulmonary BioImage Study ([www.scapis.org](www.scapis.org)) . Participants with nGER symptoms on ≥1 night per week were defined as having nGER. Chest CT was evaluated for bronchial wall thickening, bronchiectasis, reticular abnormalities, honeycombing, cysts and ground glass opacities. Ever-smoking, current asthma, inflammatory bowel disease and autoimmune disease were defined as risk factors for pulmonary abnormalities. Analyses were adjusted for sex, age, body mass index, education level and study centre.  \nResults The prevalence of nGER was 9 .4% . Among participants with risk factors for pulmonary abnormalities (n=4004), having nGER was positively associated with bronchial wall thickening (adjusted OR (aOR) (95% CI):  \n1.25 (1 .07 to 1.48)) and reticular abnormalities (aOR (95% CI): 1.51 (1 .04 to 2 . 17)), but negatively associated with cysts (aOR (95% CI): 0.68 (0.48 to 0.97)). Among participants without risk factors for CT abnormalities (n=2555), nGER did not relate with pulmonary abnormalities.  \nConclusions In a middle-aged general population, nGER was not associated with pulmonary abnormalities on chest CT. However, in the presence of other risk factors for pulmonary abnormalities, nGER was associated with bronchial wall thickening and reticular abnormalities. Persons with nGER and risk factors for pulmonary abnormalities should, therefore, be evaluated for respiratory disease and treated appropriately.  \nINTRODUCTION  \nNocturnal gastro-oesophageal reflux (nGER) is a common condition, characterised by night-time reflux of gastric content in the oesophagus, oral cavity or lungs. The main symptoms are heartburn and acid regurgitation.1 2 nGER has been suggested to be a risk factor for the development  \nWHAT IS ALREADY KNOWN ON THIS TOPIC  \n\n| ⇒ Gastro-oesophageal reflux is often considered a risk factor for interstitial lung disease and airways disease. However, good evidence is lacking, especially for early stages of disease.\u003Cbr>WHAT THIS STUDY ADDS |\n| --- |\n| ⇒ In the general population, nocturnal gastroesophageal reflux (nGER) does not independently associate with pulmonary abnormalities on chest CT. However, among individuals with other risk factors for developing pulmonary abnormalities (smoking history, asthma, inflammatory bowel disease or systemic autoimmune disease), a significant although relatively weak association was found between nGER and bronchial wall thickening and reticular abnormalities.\u003Cbr>HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICY |\n\n⇒ These results show","cbCaibLh4K7StV86","https://ap.wps.com/l/cbCaibLh4K7StV86","pdf",610322,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusions\n# Introduction\n## What is already known on this topic\n## What this study adds\n## How this study might affect research, practice or policy","[{\"question\":\"What was the primary aim of this study?\",\"answer\":\"To investigate the association between nocturnal gastro-oesophageal reflux (nGER) and pulmonary abnormalities on chest CT in an adult general population.\"},{\"question\":\"How were participants with nGER defined and what CT findings were assessed?\",\"answer\":\"Participants were defined as having nGER if they reported symptoms on at least one night per week. Chest CT was evaluated for bronchial wall thickening, bronchiectasis, reticular abnormalities, honeycombing, cysts, and ground-glass opacities.\"},{\"question\":\"What were the main findings regarding nGER and CT abnormalities?\",\"answer\":\"In the overall middle-aged general population, nGER was not independently associated with pulmonary abnormalities. However, among individuals with other pulmonary risk factors, nGER showed associations with bronchial wall thickening and reticular abnormalities, and a negative association with cysts.\"}]","Nocturnal gastro-oesophageal reflux and pulmonary abnormalities on chest CT in a general population - Research Article | PDF",1790717469,18]