[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-332364-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-332364-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","nk-cell-based-immunotherapy-against-oral-squamous-cell-carcinoma","NK cell based immunotherapy against oral squamous cell carcinoma","","Oral squamous cell carcinoma (OSCC), a major head and neck cancer subtype, faces poor therapeutic effectiveness and aggressive disease behavior. This review describes the therapeutic potential of natural killer (NK) cells in OSCC, leveraging their ability to recognize and eliminate tumor cells without prior sensitization. It explains NK cytotoxic mechanisms, including direct killing via natural cytotoxic receptors and antibody-dependent cellular cytotoxicity (ADCC). The article further surveys recent advances in engineering NK cells, such as CAR-NK strategies targeting tumor antigens, and discusses clinical integration challenges and personalized treatment prospects, outlining future research directions.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/nk-cell-based-immunotherapy-against-oral-squamous-cell-carcinoma/332364/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/nk-cell-based-immunotherapy-against-oral-squamous-cell-carcinoma/332364.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why are NK cells considered promising for OSCC treatment?","Question",{"text":63,"@type":64},"NK cells can target and eliminate cancer cells without prior sensitization. They also mediate cytotoxicity through mechanisms such as direct killing and ADCC.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What cytotoxic mechanisms does the review highlight for NK cells against tumor cells?",{"text":68,"@type":64},"The review highlights direct killing via engagement of natural cytotoxic receptors and antibody-dependent cellular cytotoxicity (ADCC).",{"name":70,"@type":61,"acceptedAnswer":71},"How do CAR-NK cell engineering approaches relate to improved antitumor activity?",{"text":72,"@type":64},"Engineering NK cells with chimeric antigen receptors (CARs) enables targeting of specific tumor antigens, aiming to enhance antitumor potency and therapeutic precision.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},332364,1790012852,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","TYPE Review  \nPUBLISHED 13 August 2024  \nDOI 10.3389/fimmu.2024.1440764  \nOPEN ACCESS  \nEDITED BY Zheran Liu,  \nSichuan University, China  \nREVIEWED BY Huaping Xiao,  \nMayo Clinic, United States Mario Perro,  \nRoche, Switzerland  \n*CORRESPONDENCE Qiurong Sun  \n [qiurongsun@gmu.edu.cn](qiurongsun@gmu.edu.cn)[ ](qiurongsun@gmu.edu.cn)Linling Ju  \n[julinling8922@163.com](julinling8922@163.com)  \nRECEIVED 30 May 2024  \nACCEPTED 29 July 2024  \nPUBLISHED 13 August 2024  \nCITATION  \nZhang Y, Xie J, Wu H, Huang J, Zheng D, Wang S, Jia X, He Z, Gong Y, Ju L and Sun Q (2024) NK cell based immunotherapy against oral squamous cell carcinoma.  \nFront. Immunol. 15:1440764 .  \ndoi: 10.3389/fimmu.2024.1440764  \nCOPYRIGHT  \n© 2024 Zhang, Xie, Wu, Huang, Zheng, Wang, Jia, He, Gong, Ju and Sun. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nNK cell based immunotherapy against oral squamous  \ncell carcinoma  \nYing Zhang 1, Jianming Xie 2, Haoran Wu 3, Jinhui Huang 3, Danna Zheng 3, Shaotong Wang 3, Xueqiang Jia 3, Zongzhong He 4, Ying Gong 5, Linling Ju 6* and Qiurong Sun 1*  \n1 Department of Stomatology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China, 2 Department of Otolaryngology & Head and Neck Surgery, Anyuan People’s hospital, Ganzhou, China, 3Southern Medical University, Guangzhou, Guangdong, China, 4 Department of Transfusion Medicine, General Hospital of Southern Theatre Command, Guangzhou,  \nGuangdong, China, 5 Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, 6 Medical School of Nantong University, Nantong Third People’s Hospital, Affiliated Nantong Hospital 3 of Nantong University, Nantong, China  \nOral squamous cell carcinoma (OSCC), a major subtype of head and neck cancers, presents significant challenges due to its aggressive feature and limited therapeutic efficacy of conventional treatments. In response to these challenges, Natural Killer (NK) cells, a vital component of the innate immune system, are being explored for their therapeutic potential in OSCC due to their inherent ability to target and eliminate cancer cells without prior sensitization. This review uniquely focuses on the evolving role of NK cells specifically in OSCC, incorporating recent advancements in CAR-NK cell engineering and personalized therapy approaches that have not been comprehensively covered in previous reviews. The mechanisms through which NK cells exert cytotoxic effects on tumor cells include direct killing through the engagement of natural cytotoxic receptors and antibody-dependent cellular cytotoxicity (ADCC), making them promising agents in cancer immunotherapy. Additionally, the article explores recent advancements in engineering NK cells to enhance their antitumor activity, such as the modification with chimeric antigen receptors (CARs) to target specific tumor antigens. Clinical implications of NK cell-based therapies, including the challenges of integrating these treatments with existing protocols and the potential for personalized therapy, are examined. The review highlights the promise of NK cell therapies in improving outcomes for OSCC patients and outlines future directions for research in this dynamic field of oncological immunotherapy.  \nKEYWORDS  \noral squamous cell carcinoma, immunotherapy, natural killer cells, tumor microenvironment, CAR-NK  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \nIntroduction  \nOSCC represents a common and formidable cancer in the head and neck area, marked by malignant growths arising from thesquamous epit","cbCaioEonGqcXkOL","https://ap.wps.com/l/cbCaioEonGqcXkOL","pdf",1894083,18,"English","# Introduction\n## Epidemiology and risk factors\n# Natural killer cells in OSCC\n## Cytotoxic mechanisms and therapeutic rationale\n## CAR-NK engineering and personalized therapy\n# Clinical implications and future directions","[{\"question\":\"Why are NK cells considered promising for OSCC treatment?\",\"answer\":\"NK cells can target and eliminate cancer cells without prior sensitization. They also mediate cytotoxicity through mechanisms such as direct killing and ADCC.\"},{\"question\":\"What cytotoxic mechanisms does the review highlight for NK cells against tumor cells?\",\"answer\":\"The review highlights direct killing via engagement of natural cytotoxic receptors and antibody-dependent cellular cytotoxicity (ADCC).\"},{\"question\":\"How do CAR-NK cell engineering approaches relate to improved antitumor activity?\",\"answer\":\"Engineering NK cells with chimeric antigen receptors (CARs) enables targeting of specific tumor antigens, aiming to enhance antitumor potency and therapeutic precision.\"}]","NK cell based immunotherapy against oral squamous cell carcinoma | PDF",1789997858,45]