[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-374294-105":59,"doc-detail-374294-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","nifedipine-versus-captopril-severe-hypertension-study-in-diabetic-patients","Nifedipine Versus Captopril - Severe Hypertension Study in Diabetic Patients","","Severe hypertension in diabetic nephropathy patients was evaluated by comparing nifedipine, a calcium channel blocker, with captopril, an ACE inhibitor. The study included 56 type II diabetic patients receiving either nifedipine or captopril without a wash-out period. Blood pressure changes were assessed alongside glucose, HbA1c, cholesterol, creatinine, proteins, and urinary albumin excretion before and after treatment. Nifedipine significantly reduced mean and diastolic pressure; captopril improved plasma proteins.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nifedipine-versus-captopril-severe-hypertension-study-in-diabetic-patients/374294/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nifedipine-versus-captopril-severe-hypertension-study-in-diabetic-patients/374294.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main goal of the study?","Question",{"text":112,"@type":113},"To evaluate the efficacy of nifedipine versus captopril in severe hypertension of diabetic nephropathy patients, including effects on side issues related to carbohydrate and lipid metabolism and progression of renal failure.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were patients treated in each group?",{"text":117,"@type":113},"Thirty-eigth patients started nifedipine (20 mg twice a day), while eighteen patients received captopril (initially 25 mg twice a day), with dose increases until acceptable blood pressure control.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key results on blood pressure and metabolic parameters?",{"text":121,"@type":113},"Both drugs significantly decreased systolic blood pressure; only nifedipine significantly decreased mean and diastolic blood pressure. No significant changes were observed for creatinine, glucose, uric acid, HbA1c, proteinuria, insulin requirements, or body weight, while cholesterol increased with nifedipine and plasma proteins improved with captopril.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},374294,1790894909,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","NIFEDIPINE VERSUS CAPTOPRIL IN THE TREATMENT OF SEVEREHYPERTENSION OF DIABETIC PATIENTS.  \nM.T.GONZALEZ,A.M.CASTELAO,J.BOVER,N.VIRGILI*,J.M.FERNANDEZ-REAL*,A.MARTINEZ AMENOS,J.ALSINA.  \nDepartment of Nephrology and Endocrinology*.Hospital de Bellvitge.Barcelona.Catalonia.Spain.  \n# INTRODUCTION\n\nDiabetes mellitus is a frequent disease.Two thirds of diabetic patientscould die from cardiovascular diseases.Control of cardiovascular riskfactors such as hypertension,hyperlipidemia and cigarrette smoking canimprove their well-being and also their expectancy of life.It seems that thecontrol of these factors can also reduce the incidence of reinopathy,renaldisease and neuropathy.  \nBased on these experiences the aim of our study is to evaluate the efficacyof two hypotensive agents which act on blood pressure by quite differentmechanisms:  calcium channel blockers (Nifedipine)and angiotensinconverting enzyme(ACE)inhibitors(Captopril)in severe hypertension ofdiabetic nephropathy patients.We have compared their potency in loweringblood pressure and the presence or absence of side effects on carbohydrateand lipid metabolism and on the progression of renal failure.MATERIAL AND METHODS  \nWe have studied 56 diabetic patients,33 males and 23 females,with type IIdiabetes mellitus,with a mean age of 60 years(42-78 years),all showingproliferative or non proliferative diabetic retinopathy,mild or moderaterenal insufficiency(creatinine\u003C375 μmol/1),high levels of proteinuria andsevere hypertension,treated or not previously by means of diversehypotensive agents.  \nThe mean age of detection of hypertension was 53±9 years.  \nThirty-eigth patients were started on nifedipine treatment(20 mg twice aday),16 as a first one .Eigthteen patients were treated by captopril,5 afterreceiving other hypotensive agents.The initial dose was 25 mg twice a day,increasing it progressively until achieving an acceptable control of bloodpressure.We have not used ,in any of the two groups,a wash-out period dueto the severity of hypertension.  \nIn addition to systolic(SBP),mean(MBP)and dyastolic(DBP)blood pressure,glucose,HBA1c,cholesterol,creatinine,  total proteins,potassium and uricacid plasma levels were controlled as well as 24-hour urine albuminexcretion rate.All these measures were done thrice before and thrice afterthe beginning of a new treatment,and the two means of these three valueswere compared.We have considered also patient's body weight and insulinrequirements in each control.  \nAll these parameters have also been compared between both groupsbefore starting treatments,in order to asses the similarity of these twogroups.Only proteinuria was greater in captopril treated patients.(p\u003C0,03)  \nThe statistic method employed was Student t-test for paired and unpaireddata.  \n# RESULTS\n\nIn both groups the decrease in SBP was significant while MBP and DBPwas only significantly decreased in nifedipine treated group.We have notobserved significant changes in creatinine,glucose,uric acid,HbA1C,proteinuria,insulin requirements and body weight of patients.Cholesterol  \n224  \nincreased in nifedipine treated patients while plasma proteins improved incaptopril treated group.(Table 1)This change in plasma protein level couldbe related with the trend of proteinuria to be decreased after captopril.DISCUSSION  \nIn diabetic patients the onset of nephropathy is a sign of bad prognosis.Hypertension can accelerate the progression of renal disease andcontribute to the increase of macro and microvascular disease.Nifedipine isknownto ameliorate microvascular diseaseby blocking the entry ofcalcium in slow calcium channels (1)which play a role invasoconstriction.  At the same time it can ameliorate ischemic heartdisturbances so frequent in diabetic patients(2).It has been published theefficacy of ACE inhibitors reducing proteinuria in the first stage of diabeticnephropathy (microalbuminuria)(3),and lowering the progression ofrenal insufficiency(4),without impairment of glucose tolerance(5).","cbCaiko2Nx8nRh2j","https://ap.wps.com/l/cbCaiko2Nx8nRh2j","pdf",101379,"English","# INTRODUCTION\n# MATERIAL AND METHODS\n# RESULTS\n# DISCUSSION\n# REFERENCES","[{\"question\":\"What was the main goal of the study?\",\"answer\":\"To evaluate the efficacy of nifedipine versus captopril in severe hypertension of diabetic nephropathy patients, including effects on side issues related to carbohydrate and lipid metabolism and progression of renal failure.\"},{\"question\":\"How were patients treated in each group?\",\"answer\":\"Thirty-eigth patients started nifedipine (20 mg twice a day), while eighteen patients received captopril (initially 25 mg twice a day), with dose increases until acceptable blood pressure control.\"},{\"question\":\"What were the key results on blood pressure and metabolic parameters?\",\"answer\":\"Both drugs significantly decreased systolic blood pressure; only nifedipine significantly decreased mean and diastolic blood pressure. No significant changes were observed for creatinine, glucose, uric acid, HbA1c, proteinuria, insulin requirements, or body weight, while cholesterol increased with nifedipine and plasma proteins improved with captopril.\"}]","Nifedipine Versus Captopril - Severe Hypertension Study in Diabetic Patients | PDF",1790201420]