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The paper tests understanding of core biology concepts through diagram- and data-based questions on DNA structure, chromosomes in prokaryotes, tRNA and translation coding, stem cell applications, mutation effects, genome composition and protein-coding calculations, enzyme active and allosteric sites, metabolic pathway product formation, inhibition effects in enzyme assays, and essentials for glycolysis. Additional items assess ATP synthesis in mitochondria, experimental design in yeast respiration using resazurin, micro-organism properties, and variables controlling E. coli growth.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":20,"@type":76,"position":81},"https://docshare.wps.com/document/exam/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nh-biology-paper-1-multiple-choice-2022/501724/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nh-biology-paper-1-multiple-choice-2022/501724.png","ImageObject",300,407,{"name":92,"@type":93},"iuabcfuw","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-10-03",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What instructions apply to Paper 1?","Question",{"text":113,"@type":114},"Attempt all questions. A calculator may be used. Instructions for completion are on page 02, and answers must be recorded on the answer grid on page 03. Rough work is at the end of the booklet, and the booklet must be returned to the Invigilator before leaving the room.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What biology topics are covered in the multiple-choice questions?",{"text":118,"@type":114},"The questions cover DNA and chromosome features, translation and tRNA, stem cell uses, mutation types, genome composition calculations, enzyme binding and induced fit, metabolic pathway graphs, inhibition effects, glycolysis requirements, ATP synthesis in mitochondria, and experimental variables in yeast and E. coli studies.",{"name":120,"@type":111,"acceptedAnswer":121},"How do questions use experimental or data evidence?",{"text":122,"@type":114},"Some items require reading graphs, pie charts, or tables to interpret concentrations or calculate protein-coding base pairs, while others ask which experimental feature ensures a valid conclusion or identify the independent variable controlling bacterial growth.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},501724,1791141141,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":19,"category_name":20,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":31,"preview_page_count":4},3985747874027,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","H  \nNational Quali􀃛cations 2022  \nX807/76/12  \nTHURSDAY, 19 MAY 9:00 AM – 9:40 AM  \nBiology  \nPaper 1—Multiple choice  \nTotal marks—25  \nAttempt ALL questions.  \nYou may use a calculator.  \nInstructions for the completion of Paper 1 are given on page 02 of your answer booklet X807/76/02 .  \nRecord your answers on the answer grid on page 03 of your answer booklet.  \nSpace for rough work is provided at the end of this booklet.  \nBefore leaving the examination room you must give your answer booklet to the Invigilator; if you do not, you may lose all the marks for this paper.  \n*X8077612*  \nA/SA  \nTotal marks—25 Attempt ALL questions  \n1. The diagram shows the structure of part of a DNA molecule.  \nsubunit X  \nprime  \nend Y  \nWhich row in the table identifies subunit X and prime end Y?  \n\n|  | Subunit X | Prime end Y |\n| --- | --- | --- |\n| A | nucleotide | 3′ |\n| B | amino acid | 5′ |\n| C | amino acid | 3′ |\n| D | nucleotide | 5′ |\n\n2. The list describes features of different chromosomes:  \n1. Circular shape.  \n2. Linear shape.  \n3. Associated with proteins.  \nWhich of the descriptions apply to chromosomes in prokaryotes?  \nA 1 only  \nB 3 only  \nC 2 and 3 only  \nD 1, 2 and 3  \n3. The diagram shows three tRNA molecules and their attached amino acids during translation.  \naa3  \nA G C  \nmRNA ribosome  \nIdentify the DNA sequence that codes for the amino acid aa1 .  \nA G T A  \nB G U A  \nC C A T  \nD C A U  \n4. Which row in the table describes research and therapeutic uses of stem cells?  \n\n|  | Research use | Therapeutic use |\n| --- | --- | --- |\n| A | To provide information on cell differentiation | To test drugs |\n| B | To test drugs | To provide information on cell differentiation |\n| C | To study how diseases develop | To repair damaged tissue |\n| D | To repair damaged tissue | To regenerate damaged skin |\n\n[Turn over  \n5. The protein dystrophin contains 3684 amino acids. A mutation in the dystrophin gene causes cells to produce a protein with 2428 amino acids.  \nWhich type of mutation could have caused this?  \nA Nonsense  \nB Duplication  \nC Missense  \nD Inversion  \n6. The pie chart shows the estimated composition of a genome.  \nexons 1.5% introns 5.0%  \nsequences coding fortRNA and rRNA 1.0%  \nregulatory sequences 20.0%  \nother sequences 72.5%  \nThe genome is estimated to contain 3200 million base pairs. Calculate how many base pairs code for protein.  \nA 32 million B 48 million C 160 million D 640 million  \n7. The diagram shows an enzyme and molecules that can bind to it.  \ninhibitor molecule  \nactive site  \nenzyme  \nallosteric site  \nsubstrate molecule  \nWhich of the following will change shape during induced fit?  \nA Active site B Allosteric site C Substrate molecule D Inhibitor molecule  \n[Turn over  \n8. The graph shows the substrate and product concentrations during a reaction in a metabolic pathway.  \nKey substrate concentration (mg/l)  \n product concentration (mg/l)  \nsubstrate concentration (mg/l)  \n100  \n80  \n60  \n40  \n20  \n0  \nproduct concentration (mg/l)  \nAt which time is the product concentration exactly 50% of the substrate concentration?  \nA 30 seconds B 60 seconds C 75 seconds D 90 seconds  \n9. Test tubes each containing an enzyme solution with different concentrations of substrate were incubated. After 10 minutes enzyme activity was measured.  \nThe results are shown in the table.  \n\n|  | Enzyme activity (units) |  |  |\n| --- | --- | --- | --- |\n| Substrate concentration (mol/l) | No inhibitor | Inhibitor X | Inhibitor Y |\n| 0.0 | 0.0 | 0.0 | 0.0 |\n| 0.2 | 0.2 | 0.1 | 0.1 |\n| 0.4 | 0.3 | 0.1 | 0.2 |\n| 0.6 | 0.4 | 0.2 | 0.4 |\n| 0.8 | 0.5 | 0.2 | 0.4 |\n| 1.0 | 0.5 | 0.2 | 0.5 |\n\nWhich of the following statements is supported by the data?  \nA Inhibitor Y changes the shape of the active site.  \nB The optimum substrate concentration is 1.0 mol/l.  \nC Inhibitor X binds to the active site.  \nD Inhibitor Y is a competitive inhibitor.  \n10. Which of the following must be present in a living cell for glycolysis to occur?  \nA","cbCaiqfIFqc1mMF7","https://ap.wps.com/l/cbCaiqfIFqc1mMF7","pdf",665039,"English","# Question 1\n## DNA structure and tRNA/translation coding\n# Question 2\n## Prokaryote chromosomes\n# Question 3\n## Translation and identifying DNA sequence\n# Question 4\n## Stem cell research vs therapeutic uses\n# Question 5\n## Mutation type in dystrophin\n# Question 6\n## Genome composition and protein-coding base pairs\n# Question 7\n## Induced fit and inhibitor/allosteric effects\n# Question 8\n## Metabolic pathway graph interpretation\n# Question 9\n## Enzyme activity with inhibitors\n# Question 10\n## Requirements for glycolysis\n# Question 11\n## ATP synthesis location in mitochondria\n# Question 12\n## Valid conclusion in yeast respiration experiment\n# Question 13\n## Correct statement about micro-organisms\n# Question 14\n## Independent variable in E. coli sugar growth study","[{\"question\":\"What instructions apply to Paper 1?\",\"answer\":\"Attempt all questions. A calculator may be used. Instructions for completion are on page 02, and answers must be recorded on the answer grid on page 03. Rough work is at the end of the booklet, and the booklet must be returned to the Invigilator before leaving the room.\"},{\"question\":\"What biology topics are covered in the multiple-choice questions?\",\"answer\":\"The questions cover DNA and chromosome features, translation and tRNA, stem cell uses, mutation types, genome composition calculations, enzyme binding and induced fit, metabolic pathway graphs, inhibition effects, glycolysis requirements, ATP synthesis in mitochondria, and experimental variables in yeast and E. coli studies.\"},{\"question\":\"How do questions use experimental or data evidence?\",\"answer\":\"Some items require reading graphs, pie charts, or tables to interpret concentrations or calculate protein-coding base pairs, while others ask which experimental feature ensures a valid conclusion or identify the independent variable controlling bacterial growth.\"}]","NH Biology Paper 1 - Multiple choice - 2022 | PDF",1791023855]