[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331480-105":59,"doc-detail-331480-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","nf-kb-signaling-pathway-in-tumor-microenvironment-review","NF-kB signaling pathway in tumor microenvironment - Review","","Tumors emerge and progress through multifactorial processes driven by genetic alterations in tumor cells and continuous bidirectional interactions with the tumor microenvironment (TME). The TME comprises tumor cells, immune and inflammatory cells, cancer-associated stromal components, microvessels, cytokines, chemokines, and extracellular matrix elements that can either suppress or promote malignancy. This review highlights how NF-kB transcription factors, central to inflammation and innate immunity, shape cancer onset and progression within the TME. By mapping NF-kB interactions across TME components, it positions NF-kB pathway targeting as a promising therapeutic strategy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/nf-kb-signaling-pathway-in-tumor-microenvironment-review/331480/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/nf-kb-signaling-pathway-in-tumor-microenvironment-review/331480.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the tumor microenvironment (TME) and why is it important for cancer?","Question",{"text":112,"@type":113},"The TME is a complex, dynamic system that includes tumor cells, immune and inflammatory cells, stromal components, microvessels, cytokines, chemokines, and extracellular matrix. Its interactions influence tumor progression, metastasis, and treatment response.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the NF-kB signaling pathway relate to the TME?",{"text":117,"@type":113},"The NF-kB pathway regulates immune and inflammatory responses, and its activity is tightly linked with multiple TME components. Persistent NF-kB activation can sustain chronic inflammation that supports tumor growth, survival, and metastasis.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is targeting the NF-kB pathway considered a promising cancer treatment approach?",{"text":121,"@type":113},"Because NF-kB signaling promotes pro-tumorigenic interactions within the TME, disrupting the NF-kB pathway may interfere with key mechanisms driving cancer development and progression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331480,1790168187,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","TYPE Review  \nPUBLISHED 18 October 2024  \nDOI 10.3389/fimmu.2024.1476030  \nOPEN ACCESS  \nEDITED BY  \nEzequiel Moise´ s Fuentes-Panana´ ,  \nFederico Go´mez Children’s Hospital, Mexico  \nREVIEWED BY  \nQian Yang,  \nCedars Sinai Medical Center, United States Xiuting Liu,  \nWashington University in St. Louis, United States  \nMinhong Shen,  \nWayne State University, United States Yenkel Grinberg-Bleyer,  \nINSERM U1052 Centre de Recherche en Cancerologie de Lyon, France  \n*CORRESPONDENCE  \nBingwei Shi  \n [sbw8133211@163.com](sbw8133211@163.com)[ ](sbw8133211@163.com)Chongxu Han  \n [Hanchongxu@126.com](Hanchongxu@126.com)  \n†These authors share first authorship  \nRECEIVED 05 August 2024  \nACCEPTED 30 September 2024  \nPUBLISHED 18 October 2024  \nCITATION  \nCao Y, Yi Y, Han C and Shi B (2024)  \nNF-kB signaling pathway in tumor microenvironment.  \nFront. Immunol. 15:1476030 .  \ndoi: 10.3389/fimmu.2024.1476030  \nCOPYRIGHT  \n© 2024 Cao, Yi, Han and Shi. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nNF-kB signaling pathway in tumor microenvironment  \nYaning Cao 1†, Yanan Yi 2†, Chongxu Han 2* and Bingwei Shi 1*  \n1 Department of Blood Transfusion, Changzhou Hospital of Traditional Chinese Medicine, Changzhou, Jiangsu, China, 2 Department of Laboratory Medicine, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, China  \nThe genesis and progression of tumors are multifaceted processes influenced by genetic mutations within the tumor cells and the dynamic interplay with their surrounding milieu, which incessantly impacts the course of cancer. The tumor microenvironment (TME) is a complex and dynamic entity that encompasses not only the tumor cells but also an array of non-cancerous cells, signaling molecules, and the extracellular matrix. This intricate network is crucial in tumor progression, metastasis, and response to treatments. The TME is populated by diverse cell types, including immune cells, fibroblasts, endothelial cells, alongside cytokines and growth factors, all of which play roles in either suppressing or fostering tumor growth. Grasping the nuances of the interactions within the TME is vital for the advancement of targeted cancer therapies. Consequently, a thorough understanding of the alterations of TME and the identification of upstream regulatory targets have emerged as a research priority. NF-kB transcription factors, central to inflammation and innate immunity, are increasingly recognized for their significant role in cancer onset and progression. This review emphasizes the crucial influence of the NF-kB signaling pathway within the TME, underscoring its roles in the development and advancement of cancer. By examining the interactions between NF-kB and various components of the TME, targeting the NF-kB pathway appears as a promising cancer treatment approach.  \nKEYWORDS  \nNF-kB signaling pathway, inflammation, tumor microenvironment, cancer metabolism, tumor immunity  \n1 Introduction  \nThe occurrence and development of tumors, from metastasis to treatment resistance, result from the mutual interaction between cancer cells and the tumor microenvironment (TME) . The TME, a complex and dynamic system, primarily comprises tumor cells, adjacent immune and inflammatory cells, tumor-related fibroblasts, surrounding stromal tissues, microvessels, and various cytokines and chemokines (1) . Tumor formation is a complex and detailed biological process where cancer cells and their surrounding TME continuously interact and regulate tumor progression. The mutations within tumor cells,  \nFrontiers in Immunology 01 [f","cbCaivuq7EzNy0NJ","https://ap.wps.com/l/cbCaivuq7EzNy0NJ","pdf",3129402,18,"English","# Introduction\n# NF-kB signaling pathway in glance","[{\"question\":\"What is the tumor microenvironment (TME) and why is it important for cancer?\",\"answer\":\"The TME is a complex, dynamic system that includes tumor cells, immune and inflammatory cells, stromal components, microvessels, cytokines, chemokines, and extracellular matrix. Its interactions influence tumor progression, metastasis, and treatment response.\"},{\"question\":\"How does the NF-kB signaling pathway relate to the TME?\",\"answer\":\"The NF-kB pathway regulates immune and inflammatory responses, and its activity is tightly linked with multiple TME components. Persistent NF-kB activation can sustain chronic inflammation that supports tumor growth, survival, and metastasis.\"},{\"question\":\"Why is targeting the NF-kB pathway considered a promising cancer treatment approach?\",\"answer\":\"Because NF-kB signaling promotes pro-tumorigenic interactions within the TME, disrupting the NF-kB pathway may interfere with key mechanisms driving cancer development and progression.\"}]","NF-kB signaling pathway in tumor microenvironment - Review | PDF",1789993454,45]