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Angiogenic signaling relies on tumor-secreted factors regulated by NF-κB, a pathway also linked to apoptosis, inflammation, differentiation, and migration. This review synthesizes mechanisms and NF-κB-based therapeutic strategies for CRC.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/nf-b-pathway-and-angiogenesis-insights-into-colorectal-cancer-development-and-therapeutic-targets/331645/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/nf-b-pathway-and-angiogenesis-insights-into-colorectal-cancer-development-and-therapeutic-targets/331645.png","ImageObject",300,407,{"name":42,"@type":43},"Genevieve","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is angiogenesis crucial in colorectal cancer progression?","Question",{"text":63,"@type":64},"Angiogenesis enables formation of new blood vessels that deliver essential nutrients and oxygen to tumor cells while supporting removal of metabolic waste, thereby promoting proliferation and dissemination.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What role does NF-κB play in CRC-related angiogenesis?",{"text":68,"@type":64},"NF-κB regulates multiple homeostatic processes and is involved in pathways connected to apoptosis, cell proliferation, inflammation, tumor migration, and angiogenesis, influencing the secretion and regulation of angiogenesis-related molecules.",{"name":70,"@type":61,"acceptedAnswer":71},"Which angiogenic molecules and pathways are discussed as important in this review?",{"text":72,"@type":64},"The review highlights tumor-secreted factors such as EGF and VEGF, and subcellular pathway regulation involving NF-κB; it also references multiple receptor/ligand and pro-angiogenic molecules linked to angiogenic control.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331645,1790154932,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Bahrami etal. European Journal  \nEuropean Journal of Medical Research (2024) 29:610  \n[https://doi.org/10.1186/s40001-024-02168-w](https://doi.org/10.1186/s40001-024-02168-w of Medical Research)[ of Medical Research](https://doi.org/10.1186/s40001-024-02168-w of Medical Research)  \n REVIEW Open Access  \nNF-κB pathway and angiogenesis:    \ninsights into colorectal cancer development and therapeutic targets  \nAshkan Bahrami 1, Amirreza Khalaji2,3, Majed Bahri Najafi4, Sina Sadati1, Arash Raisi 1,  \nAmirMohammad Abolhassani1, Reza Eshraghi1*, Mahmood Khaksary Mahabady5*, Neda Rahimian6,7,8* and Hamed Mirzaei6*  \nAbstract  \nColorectal cancer (CRC) is currently ranked as the third most common type of cancer, contributing significantly to mortality and morbidity worldwide. Epigenetic and genetic changes occurred during CRC progression resulted in the cell proliferation, cancer progression, angiogenesis, and invasion. Angiogenesis is one of the crucial steps during cancer progression required for the delivery of essential nutrients to cancer cells and removes metabolic waste. During angiogenesis, different molecules are secreted from tumoral cells to trigger vascular formation including epidermal growth factor and the vascular endothelial growth factor (VEGF) . The production and regulation of the secretion of these molecules are modulated by different subcellular pathways such as NF-κB. NF-κB is involved in regulation of different homeostatic pathways including apoptosis, cell proliferation, inflammation, differentiation, tumor migration, and angiogenesis. Investigation of different aspects of this pathway and its role in angiogenesis could provide a comprehensive overview about the underlying mechanisms and could be used for development of further therapeutic targets. In this review of literature, we comprehensively reviewed the current understanding and potential of NF-κB-related angiogenesis in CRC. Moreover, we explored the treatments that are based on the NF-κB pathway.  \nKeywords Angiogenesis, Colorectal cancer, Neovascularization, NF-κB, VEGF  \n*Correspondence:  \nReza Eshraghi[eshraghi. rza@gmail.com](eshraghi. rza@gmail.com)[ ](eshraghi. rza@gmail.com)Mahmood Khaksary Mahabady [mkhaksarymahabady@gmail.com](mkhaksarymahabady@gmail.com)[ ](mkhaksarymahabady@gmail.com)Neda Rahimian [Rahimian.n@iums.ac.ir](Rahimian.n@iums.ac.ir)  \nHamed Mirzaei[h.mirzaei2002@gmail.com](h.mirzaei2002@gmail.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/.)[.](http://creativecommons.org/licenses/by-nc-nd/4.0/.)  \nBahrami etal. European Journal of Medical Research (2024) 29:610  \nIntroduction  \nThe latest report released by the Global Cancer Observatory in 2022 states that colorectal cancer (CRC) ranks as the third most widespread type of cancer worldwide and has a significant impact on the overall number of deaths caused by cancer [1] . The m","cbCaikA4mJC3twwt","https://ap.wps.com/l/cbCaikA4mJC3twwt","pdf",1178273,13,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"Why is angiogenesis crucial in colorectal cancer progression?\",\"answer\":\"Angiogenesis enables formation of new blood vessels that deliver essential nutrients and oxygen to tumor cells while supporting removal of metabolic waste, thereby promoting proliferation and dissemination.\"},{\"question\":\"What role does NF-κB play in CRC-related angiogenesis?\",\"answer\":\"NF-κB regulates multiple homeostatic processes and is involved in pathways connected to apoptosis, cell proliferation, inflammation, tumor migration, and angiogenesis, influencing the secretion and regulation of angiogenesis-related molecules.\"},{\"question\":\"Which angiogenic molecules and pathways are discussed as important in this review?\",\"answer\":\"The review highlights tumor-secreted factors such as EGF and VEGF, and subcellular pathway regulation involving NF-κB; it also references multiple receptor/ligand and pro-angiogenic molecules linked to angiogenic control.\"}]","NF-κB pathway and angiogenesis - insights into colorectal cancer development and therapeutic targets | PDF",1789994430,33]