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This review systematizes the classification and mechanisms of nanomaterials used to improve ultrasound imaging and therapeutic performance. It covers organic nanomaterials, including nanobubbles and polymer nanoparticles, and inorganic nanomaterials such as metal and metal oxide nanoparticles. Strategies and representative applications are discussed across brain tumors, breast cancer, lung cancer, liver cancer, and pancreatic cancer, highlighting how ultrasound-guided nano-delivery improves drug delivery efficiency, helps overcome physiological barriers, and strengthens anti-tumor activity by modulating the tumor immune microenvironment. Remaining challenges include biosafety and clinical translation, and future work emphasizes optimized nanomaterial design and more robust clinical studies to advance ultrasound-nanotechnology adoption in cancer treatment.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/new-strategies-for-tumor-diagnosis-and-therapy-with-ultrasound-assisted-by-nanomaterials-review/369869/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/new-strategies-for-tumor-diagnosis-and-therapy-with-ultrasound-assisted-by-nanomaterials-review/369869.png","ImageObject",300,407,{"name":92,"@type":93},"Franzy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main purpose of this review on ultrasound-assisted nanomaterials?","Question",{"text":113,"@type":114},"To comprehensively discuss how nanomaterials enhance ultrasound imaging and therapy, including classification, mechanisms, and application strategies for different tumors.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which types of nanomaterials are covered?",{"text":118,"@type":114},"The review includes organic nanomaterials such as nanobubbles and polymer nanoparticles, as well as inorganic nanomaterials including metal nanoparticles and metal oxide nanoparticles.",{"name":120,"@type":111,"acceptedAnswer":121},"How do ultrasound technologies and nano-delivery systems contribute to tumor treatment?",{"text":122,"@type":114},"Integrating ultrasound with nano-delivery can improve drug delivery efficiency, overcome physiological barriers, and enhance anti-tumor effects by modulating the tumor immune microenvironment.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},369869,1790263814,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":31},2336478945519,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Ultrasonics Sonochemistry 121 (2025) 107542  \nContents lists available at ScienceDirect  \nUltrasonics Sonochemistry  \njournal [homepage:](homepage: www.elsevier.com/locate/ultson)[ www.elsevier.com/locate/ultson](homepage: www.elsevier.com/locate/ultson)  \nNew strategies for tumor diagnosis and therapy with ultrasound assisted by nanomaterials☆  \nWei Sang a,b,1,* , Haoliang Fan c,1, Yijun Huang d,1, Junfeng Zhang e,1, Weiqi Gaof,  \nChaoran Zhao g, Xiaoyao Liu g, Linmei Zhao h,*, Yulong Liu f,*, Yunlu Daii,j,*, Ruiping Zhang k,*  \na Shanxi Provincial People’s Hospital, Shanxi Medical University, Taiyuan, China  \nb Institute of Medical Technology, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China c School of Forensic Medicine, Shanxi Medical University, Taiyuan, China  \nd The First Clinical Medical School, Shanxi Medical University, Taiyuan, China e The Seventh Clinical Medical College of Shanxi Medical University, Linfen, China  \nf Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, China g School of Public Health, Shanxi Medical University, Taiyuan, China  \nh The Seventh Clinical Medical School of Shanxi Medical University, Linfen People’s Hospital, Linfen, China  \ni Cancer Centre and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macau SAR, China j MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau SAR, China  \nk The Radiology Department of Shanxi Provincial People’s Hospital Affiliated to Shanxi Medical University, Taiyuan, China  \nA R T I C L E I N F O  \nKeywords: Cancer Ultrasound Nanomaterial Diagnosis Therapy  \nA B S T R A C T  \nWith the development of nanomedicine and ultrasound technology, ultrasound-enhanced contrast agents and treatment platforms based on nanomaterials have become important tools for tumor diagnosis and treatment, owing to their high safety profile, low cost and excellent biocompatibility. This review comprehensively discusses the classification and mechanism of nanomaterials in enhancing ultrasound imaging and treatment. It encompasses organic nanomaterials, including nanobubbles and polymer nanoparticles, and as well as inorganic nanomaterials, such as metal nanoparticles and metal oxide nanoparticles. The application strategies and typical examples of combining nanomaterials with ultrasound technology for different tumors are elaborated, including brain tumors, breast cancer, lung cancer, liver cancer and pancreatic cancer. Numerous studies have demonstrated that integrating ultrasound technology with nano-delivery systems can improve drug delivery efficiency and overcome physiological barriers. This integration can also enhance anti-tumor effects by modulating the tumor immune microenvironment. Despite the significant progress in this field, challenges regarding the biosafety and clinical translation of nanomaterials remain. Future research should concentrate on optimizing the design of nanomaterials and strengthening clinical studies. This will promote the widespread application of ultrasound and nanotechnology in tumor treatment.  \n1. Introduction  \nCancer, a principal cause of human mortality, primarily originates from the uncontrolled proliferation and malignant spread of tumor cells [1]. Early diagnosis is pivotal for effective cancer treatment. Despite the availability of a variety of clinical imaging techniques, each has significant limitations. For instance, fluorescence imaging is affected by  \nlimited tissue penetration and signal dispersion; magnetic resonance imaging is time-consuming; and positron emission tomographycomputed tomography entails high costs [2]. Ultrasound, a conventional diagnostic imaging modality, stands out as the most widely used clinical method for disease diagnosis and therapy due to its non-invasive nature, real-time imaging capability, and convenience, when compared to other imaging ","cbCaifoEbTO8z7um","https://ap.wps.com/l/cbCaifoEbTO8z7um","pdf",21985682,"English","# Contents\n## Abstract\n## 1. Introduction\n## 2. (Not shown in provided text)","[{\"question\":\"What is the main purpose of this review on ultrasound-assisted nanomaterials?\",\"answer\":\"To comprehensively discuss how nanomaterials enhance ultrasound imaging and therapy, including classification, mechanisms, and application strategies for different tumors.\"},{\"question\":\"Which types of nanomaterials are covered?\",\"answer\":\"The review includes organic nanomaterials such as nanobubbles and polymer nanoparticles, as well as inorganic nanomaterials including metal nanoparticles and metal oxide nanoparticles.\"},{\"question\":\"How do ultrasound technologies and nano-delivery systems contribute to tumor treatment?\",\"answer\":\"Integrating ultrasound with nano-delivery can improve drug delivery efficiency, overcome physiological barriers, and enhance anti-tumor effects by modulating the tumor immune microenvironment.\"}]","New strategies for tumor diagnosis and therapy with ultrasound assisted by nanomaterials - Review | PDF",1790184972]