[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436689-105":59,"doc-detail-436689-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","new-strategies-accelerate-the-path-to-overcome-refractory-interstitial-cystitis","New strategies accelerate the path to overcome refractory interstitial cystitis","","Editorial introducing a new management approach for refractory interstitial cystitis (IC), a troublesome chronic inflammatory female pelvic floor disorder diagnosed late and often resistant to standard options such as intravesical hyaluronic acid. It highlights an article exploring intravesical nanofat combined with platelet-rich plasma (PRP) in women with refractory IC and summarizes reported improvements in pain and symptom/probability measures. The piece frames the strategy within regenerative medicine and explains potential roles of adipose-derived stem cells and reparative mechanisms.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/new-strategies-accelerate-the-path-to-overcome-refractory-interstitial-cystitis/436689/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/new-strategies-accelerate-the-path-to-overcome-refractory-interstitial-cystitis/436689.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn Holloway","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is refractory interstitial cystitis particularly challenging to manage?","Question",{"text":112,"@type":113},"Refractory IC persists because etiology is uncertain and diagnosis is often delayed, while a substantial portion of patients do not respond to conventional treatments such as intravesical hyaluronic acid.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What new strategy is discussed for refractory IC?",{"text":117,"@type":113},"The editorial discusses a study using intravesical therapy combining autologous emulsified fat (nanofat) with platelet-rich plasma (PRP) for women with refractory IC.",{"name":119,"@type":110,"acceptedAnswer":120},"What improvements were reported after nanofat plus PRP treatment?",{"text":121,"@type":113},"The authors reported marked improvements across overall bladder conditions measured by pain scales and IC symptom/problem indices, along with a global response assessment.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436689,1791122425,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":24,"preview_page_count":4},2336474466712,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","J Chin MedAssoc  \nEditorial  \nNew strategies accelerate the path to overcome refractory interstitial cystitis  \nYiu-Tai Lia, Wen-Hsun Changb,c,d, Peng-Hui Wangc,d,e,f,*  \naDepartment of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan, ROC; bDepartment of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; cDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; dInstitute of Clinical Medicine, National Yang Ming Chiao Tung University; eFemale Cancer Foundation, Taipei, Taiwan, ROC; fDepartment of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC  \nFemale pelvic floor disorders, a chronic, complex and inflammatory disease, including overactive bladder, stress urinary incontinence, pelvic organ prolapse, and interstitial cystitis (IC), are increasing prevalent on a global scale, which significantly affect quality of life, such as increased health care visits, disturbance of sleep, higher rates of depression and anxiety, increased risk of fall-related injuries, increased risk of urinary tract infection, and reduced work productivity, leading to significant social and economic burdens.1–7 Among these female pelvic floor disorders, IC (also called as bladder pain syndrome) may be one of the most troublesome disorder, because etiology is still uncertain, and diagnosis remains by exclusion as well as the diagnosis is often delayed in the patient’s journey, contributing to a profound impact on the emotional, psychological, and social well-being of the patient.5–8 Due to aforementioned reasons, the management of women with IC is still a biggest challenge for both physicians and patients. Although hyaluronic acid (HA, hyaluronan), a hydrophilic glycosaminoglycan (GAG) macromolecules with –COOH and –OH functional groups, as a member of the polysaccharides family, plays a critical role in the extracellular matrix (ECM) and provides evidence showing the accumulation of HA may trigger the regeneration process of injuries endothelium or epithelium of urinary bladder (IC) to reach the restoration of normal urinary bladder function,5–7,9–11 there is no doubt that some patients with IC (30%-40%) will not respond to intravesical HA and/or treatment provided by other conventional strategies, and this clinical situation is called as refractory IC.5,6 In the current issue of the Journal of the Chinese Medical Association, we are happy to learn the research addressing this-type problem (refractory IC) . Hung et al12 tried to investigate whether the use of the combination of an autologous emulsified fat (nanofat) and platelet-rich plasma (PRP) could provide a new vision or strategy in the management of the women with refractory IC or not.  \n*Address correspondence. Dr. Peng-Hui Wang, Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, 201, Section 2, Shi-Pai Road, Taipei 112, Taiwan, [ROC. E-mail address: phwang@vghtpe.gov.tw](ROC. E-mail address: phwang@vghtpe.gov.tw) (P.-H. Wang). Conflicts of interest: Dr. Peng-Hui Wang, an editorial board member at Journal of the Chinese Medical Association, had no role in the peer review process of or decision to publish this article. The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2022) 85: 665-666.  \nReceived March 24, 2022; accepted April 11, 2022.  \ndoi: 10. 1097/JCMA.0000000000000733.  \nCopyright © 2022, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/))  \nThe authors enrolled six women with refractory IC who were treated with intravesical therapy of nanofat and PRP combination and found that all patients had marked improvement of the overall bladder conditions on Pain Visual Analog Scale, Interstitial Cystitis Symptom and Pr","cbCaif8vsClNxqsH","https://ap.wps.com/l/cbCaif8vsClNxqsH","pdf",291530,"English","# Editorial\n## Burden of interstitial cystitis and refractory cases\n## Rationale for nanofat plus PRP\n## Regenerative medicine mechanisms in refractory IC\n## Outcomes and clinical implications","[{\"question\":\"Why is refractory interstitial cystitis particularly challenging to manage?\",\"answer\":\"Refractory IC persists because etiology is uncertain and diagnosis is often delayed, while a substantial portion of patients do not respond to conventional treatments such as intravesical hyaluronic acid.\"},{\"question\":\"What new strategy is discussed for refractory IC?\",\"answer\":\"The editorial discusses a study using intravesical therapy combining autologous emulsified fat (nanofat) with platelet-rich plasma (PRP) for women with refractory IC.\"},{\"question\":\"What improvements were reported after nanofat plus PRP treatment?\",\"answer\":\"The authors reported marked improvements across overall bladder conditions measured by pain scales and IC symptom/problem indices, along with a global response assessment.\"}]","New strategies accelerate the path to overcome refractory interstitial cystitis | PDF",1790678764]